4-Mercaptophenylacetic acid

Last updated
4-Mercaptophenylacetic acid
4-Mercaptophenylacetic acid (MPAA).svg
Names
Preferred IUPAC name
(4-Sulfanylphenyl)acetic acid
Other names
2-(4-Mercaptophenyl)acetic acid
4-Mercaptophenylacetic acid
MPAA
Identifiers
ChemSpider
ECHA InfoCard 100.156.056
Properties
HSC6H4CH2CO2H
Molar mass 168.21 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
X mark.svgN (what is  Yes check.svgYX mark.svgN ?)
Infobox references

MPAA (4-Mercaptophenylacetic acid) is a redox buffer that increases the folding rate of disulfide-containing proteins.

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

MPAA is also used in native chemical ligation as a thiol catalyst.

Native chemical ligation or NCL is an important extension of the chemical ligation field, a concept for constructing a large polypeptide formed by the assembling of two or more unprotected peptides segments. Especially, NCL is the most powerful ligation method for synthesizing native backbone proteins or modified proteins of moderate size.

Thiol any organic compound having a sulfanyl group

Thiol is an organosulfur compound of the form R-SH, where R represents an alkyl or other organic substituent. Thiols are the sulfur analogue of alcohols, and the word is a portmanteau of "thion" + "alcohol," with the first word deriving from Greek θεῖον (theion) = "sulfur". The –SH functional group itself is referred to as either a thiol group or a sulfhydryl group.

Catalysis chemical process

Catalysis is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst, which is not consumed in the catalyzed reaction and can continue to act repeatedly. Because of this, only very small amounts of catalyst are required to alter the reaction rate in principle.


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