Apolipoprotein O

APOO
Identifiers
Aliases	APOO , FAM121B, MIC26, Mic23, My025, Apolipoprotein O, MICOS26
External IDs	OMIM: 300753 MGI: 1915566 HomoloGene: 11475 GeneCards: APOO
Gene location (Human) Chr. X chromosome (human) [1] Band Xp22.11 Start 23,833,353 bp [1] End 23,907,938 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X C3 Start 93,410,723 bp [2] End 93,460,699 bp [2]
RNA expression pattern Bgee Top expressed in right ventricle superior frontal gyrus left ventricle prefrontal cortex myocardium Brodmann area 9 More reference expression data BioGPS n/a
Gene ontology Molecular function GO:0001948 protein binding Cellular component high-density lipoprotein particle extracellular region mitochondrial inner membrane endoplasmic reticulum membrane very-low-density lipoprotein particle Golgi membrane Golgi apparatus membrane integral component of membrane integral component of mitochondrial inner membrane mitochondrion endoplasmic reticulum low-density lipoprotein particle MICOS complex extracellular space cytosol Biological process lipid transport cristae formation transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79135	68316
Ensembl	ENSG00000184831	ENSMUSG00000079508
UniProt	Q9BUR5	Q9DCZ4
RefSeq (mRNA)	NM_024122	NM_001199337 NM_001199338 NM_001199339 NM_026673
RefSeq (protein)	NP_077027	NP_001186266 NP_001186267 NP_001186268 NP_080949
Location (UCSC)	Chr X: 23.83 – 23.91 Mb	Chr X: 93.41 – 93.46 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

ApoO
Identifiers
Symbol	ApoO
Pfam	PF09769
InterPro	IPR019166
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Apolipoprotein O also known as protein FAM121B is a protein that in humans is encoded by the APOO gene. APOO is a member of the apolipoprotein family. ^[5]

The human, apolipoprotein O is a 198 amino acids protein that contains a 23 amino acids long signal peptide. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. Apolipoprotein O is the first chondroitine sulphate chain containing apolipoprotein. ^[5]

Apolipoproteins are proteins that binds to lipids. Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL.

References

1. GRCh38: Ensembl release 89: ENSG00000184831 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000079508 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lamant M, Smih F, Harmancey R, Philip-Couderc P, Pathak A, Roncalli J, Galinier M, Collet X, Massabuau P, Senard JM, Rouet P (November 2006). "ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart". J. Biol. Chem. 281 (47): 36289–302. doi: 10.1074/jbc.M510861200 . PMID   16956892.

External links

• Human APOO genome location and APOO gene details page in the UCSC Genome Browser .

Further reading

• Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC   2775832 . PMID   19913121.

This article incorporates text from the public domain Pfam and InterPro: IPR019166