Archaeosine synthase

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Archaeosine synthase
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EC no. 2.6.1.97
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Archaeosine synthase (EC 2.6.1.97, ArcS, TgtA2, MJ1022 (gene), glutamine:preQ0-tRNA amidinotransferase) is an enzyme with systematic name L-glutamine:7-cyano-7-carbaguanine aminotransferase. [1] [2] This enzyme catalyses the following chemical reaction

L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O L-glutamate + archaeine15 in tRNA

In Euryarchaeota the reaction is catalysed by ArcS.

Related Research Articles

In molecular biology, biosynthesis is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms. In biosynthesis, simple compounds are modified, converted into other compounds, or joined to form macromolecules. This process often consists of metabolic pathways. Some of these biosynthetic pathways are located within a single cellular organelle, while others involve enzymes that are located within multiple cellular organelles. Examples of these biosynthetic pathways include the production of lipid membrane components and nucleotides. Biosynthesis is usually synonymous with anabolism.

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References

  1. ↑ Phillips G, Chikwana VM, Maxwell A, El-Yacoubi B, Swairjo MA, Iwata-Reuyl D, de Crécy-Lagard V (April 2010). "Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA". The Journal of Biological Chemistry. 285 (17): 12706–13. doi: 10.1074/jbc.M110.102236 . PMC   2857094 . PMID   20129918.
  2. ↑ Phillips G, Swairjo MA, Gaston KW, Bailly M, Limbach PA, Iwata-Reuyl D, de Crécy-Lagard V (February 2012). "Diversity of archaeosine synthesis in crenarchaeota". ACS Chemical Biology. 7 (2): 300–5. doi:10.1021/cb200361w. PMC   3289047 . PMID   22032275.
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