BAY-1158061

Last updated

BAY-1158061
Clinical data
Other namesBAY1158061; HMI-115; HMI115
Routes of
administration 		Subcutaneous injection [1]
Drug class Prolactin receptor monoclonal antibody
ATC code
  • None
Pharmacokinetic data
Elimination half-life 9–16 days [2]

BAY-1158061, also known as HMI-115, is a monoclonal antibody against the prolactin receptor (PRLR) which is under development for the treatment of alopecia and endometriosis. [1] [3] It is taken by long-lasting subcutaneous injection. [1] [2] BAY-1158061 has been reported to promote hair growth in balding stump-tailed macaques. [4] The drug was first described in the scientific literature by 2018. [2] [5] [4] It is under development by Bayer and Hope Medicine. [1] [3] As of June 2025, BAY-1158061 is in phase 2 clinical trials for alopecia and endometriosis. [1] [3] Multiple phase 2 trials have been completed, including trials for both alopecia and endometriosis. [1] The chemical structure of BAY-1158061 does not yet appear to have been disclosed. [1]

Contents

See also

References

  1. 1 2 3 4 5 6 7 "BAY 1158061". AdisInsight. 28 June 2025. Retrieved 14 November 2025.
  2. 1 2 3 Nave R, Jodl S, Hoffmann A, Gashaw I, Zollmann F, Berse M, et al. (April 2019). "Monoclonal Antibody Against Prolactin Receptor: A Randomized Placebo-Controlled Study Evaluating Safety, Tolerability, and Pharmacokinetics of Repeated Subcutaneous Administrations in Postmenopausal Women". Reproductive Sciences. 26 (4): 523–531. doi:10.1177/1933719118776806. PMID   29806538.
  3. 1 2 3 "Delving into the Latest Updates on BAY-1158061 with Synapse". Synapse. 16 May 2025. Retrieved 14 November 2025.
  4. 1 2 WO 2019/011719,May E, JODL SJ, Krätzschmar J, Otto C,"Prolactin receptor antibody for male and female pattern hair loss",published 17 January 2019, assigned to Bayer Pharma AG
  5. ↑ Guo SW, Groothuis PG (September 2018). "Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis?". Human Reproduction Update. 24 (5): 577–598. doi:10.1093/humupd/dmy020. PMID   29893860.
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