C17orf107

C17orf107
Identifiers
Aliases	C17orf107 , chromosome 17 open reading frame 107
External IDs	MGI: 2148639; HomoloGene: 109413; GeneCards: C17orf107; OMA:C17orf107 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.2 Start 4,899,418 bp [1] End 4,902,934 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B3 Start 70,506,674 bp [2] End 70,507,716 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary right auricle of heart bone marrow cells thymus prefrontal cortex right lobe of liver primary visual cortex stromal cell of endometrium olfactory zone of nasal mucosa salivary gland Top expressed in testicle spermatid skeletal muscle tissue quadriceps femoris muscle spermatocyte muscle of thigh embryo embryo lip esophagus More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 100130311 668433 Ensembl ENSG00000205710 ENSMUSG00000087279 UniProt Q6ZR85 n/a RefSeq (mRNA) NM_001145536 NM_001145537 RefSeq (protein) NP_001139008 n/a Location (UCSC) Chr 17: 4.9 – 4.9 Mb Chr 11: 70.51 – 70.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chromosome 17 Open Reading Frame 107 is a protein encoded by the C17orf107 gene in Homo sapiens . C17orf107 in located intracellularly with a secondary strucutre of five alpha helixes.

Gene

Location

Human C17orf107 is located on the short arm of chromosome 17 at p 13.2. With introns, the gene spans nucleotides 4,899,536 to 4,906,715. The spliced gene is 3,201 nucleotides with three exons on the plus strand. ^[5]

Gene Level Regulation

Human C17orf107 is expressed ubiquitously in tissues with the heart and brain tissues having a higher expression and the endocrine and salivary gland tissues having the highest expression. ^{[5] [6]}

Protein

iTasser Secondary Structure of human C17orf107 protein with 5 alpha helixes in magenta and coils in blue.

Human C17orf107 protein, encoded by the mRNA sequence, is 190 amino acids in length. The molecular mass of the protein is approximately 20 kDa with a basal isoelectric point of 7 pH. ^[7] C17orf107 is a part of the DUFF5536 conserved protein domain which is part of the pfam17688, a member of the superfamily cl39220. ^[8]

Protein Level Regulation

Human C17orf107 protein is localized intracellularly with no transmembrane domains. Their is evidence of being expressed in the nucleoplasm. ^[6] The protein has no asparagines, therefore there are no N-glycosylation sites. ^[9] C17orf107 protein does not have post-translational modifications, disulfide bonds, or signal peptides. ^[10]

Evolution

Orthologs

Human C17orf107 is found in all mammals except Monotremes, Hyracoidea, Tubulidentata, Cingulata, Peramelemorphia, Paucituberculata, Sirenia, and Notoryctemorphia groups. ^[11] The C17orf107 gene first appeared in mammals with the earliest found species dating back to 160 million years ago in marsupials. ^[12] The table below shows protein orthologs to Human C17orf107, sorted by estimated date of divergence, then by taxonomic group, and lastly sequence identity scores.

Orthologs

Taxonomic Group	Common Name	Genus and Species	Accession Number	Date of Divergence (MYA)	Sequence Length (aa)	Sequence Identity (%)	Sequence Similarity (%)	Sequence Gaps (%)
Primates	Human	Homo sapiens	NP_001139008.1 [13]	—	190	—	—	—
	Western Lowland Gorilla	Gorilla gorilla gorilla	XP_018868465.1 [14]	9	189	82	83	15
Lagomorpha	European Rabbit	Oryctolagus cuniculus	XP_008269053.1 [15]	87	204	64	72	13
Rodentia	House Mouse	Mus musculus	EDL12584.1 [16]	87	128	33	37	55
Artiodactyla	East African Hippopotamus	Hippopotamus amphibius kiboko	XP_057569928.1 [17]	94	183	78	84	4
	Sheep	Ovis aries	KAG5203555.1 [18]	94	233	51	55	34
	Wild Bactrian Camel	Camelus ferus	EPY72335.1 [19]	94	183	43	50	32
Carnivora	Sea Otter	Enhydra lutris kenyoni	XP_022380488.1 [20]	94	216	63	69	19
	Giant Panda	Ailuropoda melanoleuca	XP_034502549.1 [21]	94	247	58	63	25
	Clouded Leopard	Neofelis nebulosa	XP_058561310.1 [22]	94	90	40	44	53
Cetacea	Harbor Porpoise	Phocoena phocoena	XP_065753064.1 [23]	94	179	70	79	11
	Narwhal	Monodon monoceros	TKC42450.1 [24]	94	263	26	30	51
Chiroptera	Nathusius Pipistrelle Bat	Pipistrellus nathusii	CAK6437783.1 [25]	94	135	39	45	42
Perissodactyla	Horse	Equus caballus	XP_005597777.1 [26]	94	212	69	75	16
	Southern White Rhinoceros	Diceros bicornis minor	XP_058415933.1 [27]	94	218	67	75	13
Pholidota	Sunda Pangolin	Manis javanica	XP_017503787.1 [28]	94	197	65	73	8
Proboscidea	Indian Elephant	Elephas maximus indicus	XP_049717565.1 [29]	99	248	56	62	26
Marsupial	Agile Gracile Opossom	Gracilinanus agilis	XP_044529018.1 [30]	160	179	50	52	22
	Tasmanian Devil	Sarcophilus harrisii	XP_012404229.1 [31]	160	189	48	59	22
	Monito Del Monte	Dromiciops gliroides	XP_043856787.1 [32]	160	198	41	52	20

References

1. GRCh38: Ensembl release 89: ENSG00000205710 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000087279 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "C17orf107 chromosome 17 open reading frame 107". National Library of Medicine. Retrieved 4 December 2024.
6. "C17orf107". The Human Protein Atlas. Retrieved 11 December 2024.
7. "Uncharacterized protein C17orf107". PhosphoSitePlus. Cell Signaling Technology. Retrieved 4 December 2024.
8. "Conserved Protein Domain Family DUF5536". NCBI. Retrieved 11 December 2024.
9. "NetNGlyc". DTU Health Tech. Retrieved 11 December 2024.
10. "Protter". ETHZürich. Retrieved 11 December 2024.
11. "NCBI Blast". National Library of Medicine. Retrieved 11 December 2024.
12. "Divergence Time". TimeTree5. Retrieved 11 December 2024.
13. "uncharacterized protein C17orf107 [Homo sapiens]". National Library of Medicine. Retrieved 11 December 2024.
14. "uncharacterized protein C17orf107 homolog [Gorilla gorilla gorilla]". National Library of Medicine. Retrieved 11 December 2024.
15. "uncharacterized protein C17orf107 homolog [Oryctolagus cuniculus]". National Library of Medicine. Retrieved 11 December 2024.
16. "mCG21181, isoform CRA_a, partial [Mus musculus]". National Library of Medicine. Retrieved 11 December 2024.
17. "uncharacterized protein C17orf107 homolog [Hippopotamus amphibius kiboko]". National Library of Medicine. Retrieved 11 December 2024.
18. "hypothetical protein JEQ12_003138 [Ovis aries]". National Library of Medicine. Retrieved 11 December 2024.
19. "hypothetical protein CB1_083302001 [Camelus ferus]". National Library of Medicine. Retrieved 11 December 2024.
20. "uncharacterized protein C17orf107 homolog [Enhydra lutris kenyoni]". National Library of Medicine. Retrieved 11 December 2024.
21. "uncharacterized protein C17orf107 homolog [Ailuropoda melanoleuca]". National Library of Medicine. Retrieved 11 December 2024.
22. "uncharacterized protein C17orf107 homolog [Neofelis nebulosa]". National Library of Medicine. Retrieved 11 December 2024.
23. "uncharacterized protein C17orf107 homolog, partial [Phocoena phocoena]". National Library of Medicine. Retrieved 11 December 2024.
24. "hypothetical protein EI555_006246, partial [Monodon monoceros]". National Library of Medicine. Retrieved 11 December 2024.
25. "unnamed protein product [Pipistrellus nathusii]". National Library of Medicine. Retrieved 11 December 2024.
26. "uncharacterized protein C17orf107 homolog [Equus caballus]". National Library of Medicine. Retrieved 11 December 2024.
27. "uncharacterized protein C17orf107 homolog isoform X1 [Diceros bicornis minor]". National Library of Medicine. Retrieved 11 December 2024.
28. "LOW QUALITY PROTEIN: uncharacterized protein C17orf107 homolog [Manis javanica]". National Library of Medicine. Retrieved 11 December 2024.
29. "uncharacterized protein C17orf107 homolog [Elephas maximus indicus]". National Library of Medicine. Retrieved 11 December 2024.
30. "uncharacterized protein C17orf107 homolog [Gracilinanus agilis]". National Library of Medicine. Retrieved 11 December 2024.
31. "uncharacterized protein C17orf107 homolog [Sarcophilus harrisii]". National Library of Medicine. Retrieved 11 December 2024.
32. "LOW QUALITY PROTEIN: uncharacterized protein C17orf107 homolog [Dromiciops gliroides]". National Library of Medicine. Retrieved 11 December 2024.