CNTNAP4

Last updated
CNTNAP4
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CNTNAP4 , CASPR4, contactin associated protein like 4, contactin associated protein family member 4
External IDs OMIM: 610518 MGI: 2183572 HomoloGene: 24912 GeneCards: CNTNAP4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_130457

RefSeq (protein)

NP_569724

Location (UCSC) Chr 16: 76.28 – 76.56 Mb Chr 8: 113.3 – 113.61 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Contactin-associated protein-like 4 is a protein that in humans is encoded by the CNTNAP4 gene. [5] [6]

This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. Alternative splicing results in two transcript variants encoding different isoforms. [6]

Related Research Articles

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CASPR also known as Contactin associated protein 1, Paranodin and CASPR1 is a protein that in humans is encoded by the CNTNAP1 gene. CASPR is a part of the neurexin family of proteins, hence its another name "Neurexin IV". CASPR is a membrane protein found in the neuronal membrane in the paranodal section of the axon[[]] in myelinated neurons, between the Nodes of Ranvier containing Na+ channels, and juxtaparanode, which contains K+ channels. During myelination, caspr associates with contactin in a cis complex, though its precise role in myelination is not yet understood.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000152910 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031772 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Spiegel I, Salomon D, Erne B, Schaeren-Wiemers N, Peles E (Jul 2002). "Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains". Mol Cell Neurosci. 20 (2): 283–97. doi:10.1006/mcne.2002.1110. PMID   12093160. S2CID   25024421.
  6. 1 2 "Entrez Gene: CNTNAP4 contactin associated protein-like 4".

Further reading