CNTNAP4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CNTNAP4 , CASPR4, contactin associated protein like 4, contactin associated protein family member 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 610518 MGI: 2183572 HomoloGene: 24912 GeneCards: CNTNAP4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Contactin-associated protein-like 4 is a protein that in humans is encoded by the CNTNAP4 gene. [5] [6]
This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. Alternative splicing results in two transcript variants encoding different isoforms. [6]
Contactin-associated protein-like 2 is a protein that in humans is encoded by the CNTNAP2 gene. Since the most recent reference human genome GRCh38, CNTNAP2 is the longest gene in the human genome
ATP-binding cassette sub-family B member 9 is a protein that in humans is encoded by the ABCB9 gene.
Oxysterol-binding protein-related protein 5 is a protein that in humans is encoded by the OSBPL5 gene.
Neuroligin-1 is a protein that in humans is encoded by the NLGN1 gene.
Protein SMG5 is a protein that in humans is encoded by the SMG5 gene. This protein contains a PIN domain that appears to have mutated the residues in the active site.
Transcription factor TFIIIB component B″ homolog also known as TFIIIB150 is a protein that in humans is encoded by the BDP1 gene.
Neurexin-2-alpha is a protein that in humans is encoded by the NRXN2 gene.
Neurexin-3-alpha is a protein that in humans is encoded by the NRXN3 gene.
Zinc finger CCHC domain-containing protein 2 is a protein that in humans is encoded by the ZCCHC2 gene.
Uveal autoantigen with coiled-coil domains and ankyrin repeats is a protein that in humans is encoded by the UACA gene.
Exportin-4 is a protein that in humans is encoded by the XPO4 gene.
SCAN domain-containing protein 3 is a protein that in humans is encoded by the SCAND3 gene.
PDZ domain-containing RING finger protein 3 is a protein that in humans is encoded by the PDZRN3 gene.
EF-hand calcium-binding domain-containing protein 6 is a protein that in humans is encoded by the EFCAB6 gene.
Neurexophilin-3 is a protein that in humans is encoded by the NXPH3 gene.
DnaJ (Hsp40) homolog, subfamily C, member 13, also known as DNAJC13, is a human gene.
Neuron navigator 1 is a protein that in humans is encoded by the NAV1 gene.
FCH and double SH3 domains protein 1 is a protein that in humans is encoded by the FCHSD1 gene.
Chloride channel CLIC-like 1 also known as CLCC1 is a human gene.
CASPR also known as Contactin associated protein 1, Paranodin and CASPR1 is a protein that in humans is encoded by the CNTNAP1 gene. CASPR is a part of the neurexin family of proteins, hence its another name "Neurexin IV". CASPR is a membrane protein found in the neuronal membrane in the paranodal section of the axon[[]] in myelinated neurons, between the Nodes of Ranvier containing Na+ channels, and juxtaparanode, which contains K+ channels. During myelination, caspr associates with contactin in a cis complex, though its precise role in myelination is not yet understood.