Campylobacter concisus

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Campylobacter concisus
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Bacteria
Phylum: Campylobacterota
Class: "Campylobacteria"
Order: Campylobacterales
Family: Campylobacteraceae
Genus: Campylobacter
Species:
C. concisus
Binomial name
Campylobacter concisus
Tanner et al., 1981

Campylobacter concisus is a Gram-negative, highly fastidious, mesophilic bacterium that grows under both anaerobic and microaerobic conditions with the presence of hydrogen significantly aiding growth. [1] Motile, with either unipolar or bipolar flagella, the organisms have a characteristic spiral/corkscrew appearance and are oxidase-positive. [2] [3] [4] Although the human oral cavity is the natural colonization site of the bacterium, C. concisus may also colonize the intestinal tract of some individuals. [5] In particular, several studies have reported higher intestinal prevalence of C. concisus in patients with IBD compared to healthy controls, [6] [7] which has led to current speculation of the bacterium's implication in the induction of Crohn's disease.

A number of studies have defined C. concisus to be composed of two phenotypically identical, yet genomically distinct genomospecies by analysis of amplified fragment length polymorphisms (AFLP), housekeeping genes and a PCR method targeting the polymorphisms of C. concisus 23S rRNA gene. [8] [9] [10] [11] [12] [13] The two genomospecies appear to harbor different levels of enteric pathogenic potential, with oral C. concisus strains that were invasive to human epithelial cell line (Caco2) found only in Genomospecies-2 (GS2). [14] [15]

Recently, a C. concisus molecular marker csep1, particularly the csep1 gene with a six-nucleotide insertion (csep1-6bpi) was found to be associated with active Crohn's disease, and pSma1 plasmid was found to be associated with severe ulcerative colitis. [16] [17] The csep1 gene can be located in either the pICON plasmid or the chromosome.

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References

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