Centruroides baergi

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Centruroides baergi
Scientific classification Red Pencil Icon.png
Kingdom: Animalia
Phylum: Arthropoda
Subphylum: Chelicerata
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Centruroides
Species:
C. baergi
Binomial name
Centruroides baergi
Hoffman, 1932 [1]

Centruroides baergi is a species of scorpion in the family Buthidae. [2] They are commonly found in highlands and are almost exclusively found in the states of Oaxaca and southern Puebla, Mexico. [3] [4] C. baergi is the most abundant scorpion of the genus in the state of Oaxaca, making up a third of Centruroides reported between 2008 and 2014. [4]

Venom

The three main toxins that make up the venom of C. baergi are beta toxins. [5] These toxins modify the activation threshold of sodium channels, making the channels more likely to open when normally they would not. Since sodium channels are widely found in the peripheral nervous system, their opening can lead to severe autonomic dysfunction. [6] The two most harmful of these toxins can not be neutralized by the currently available antibodies, likely due to the venom not being deemed medically important. [5]

Some of the symptoms of a sting include intense pain, salivation, vomiting, breathing difficulties, tightness in the chest, muscle stiffness, tingling and sweating. [7] [8] [9]

Related Research Articles

<i>Centruroides exilicauda</i>

Centruroides exilicauda, the Baja California bark scorpion, is a species of bark scorpion found in Baja California. It is closely related to the Arizona bark scorpion, but is not considered dangerous. Previously only distinguished by geographic range, the two variants were classified in 1980 as the same species. Subsequently, differences in venom toxicity were recorded, and in 2004, DNA analysis showed them to be separate species. The Baja California bark scorpion is a slender, long-tailed scorpion, and although it is typically sand-colored it appears in darker colors.

Tityustoxin is a toxin found in the venom of scorpions from the subfamily Tityinae. By binding to voltage-dependent sodium ion channels and potassium channels, they cause sialorrhea, lacrimation and rhinorrhea.

Birtoxin is a neurotoxin from the venom of the South African Spitting scorpion. By changing sodium channel activation, the toxin promotes spontaneous and repetitive firing much like pyrethroid insecticides do

Bestoxin is a neurotoxin from the venom of the South African spitting scorpion Parabuthus transvaalicus. Most likely, it targets sodium channel function, thus promoting spontaneous and repetitive neuronal firing. Following injection into mice, it causes non-lethal writhing behaviour.

BmKAEP is a neurotoxin from the venom of the Manchurian scorpion (Mesobuthus martensii). It is a β-toxin, which shift the activation voltage of sodium channels towards more negative potentials.

<i>Olivierus martensii</i> Species of scorpion

Olivierus martensii is a species of scorpion in the family Buthidae. Its common names include Chinese scorpion, Manchurian scorpion, Chinese armor-tail scorpion and Chinese golden scorpion. Despite its common name, this scorpion is not only found in Manchuria or China, but also in Mongolia and Korea. The record from Japan is doubtful. Its preferred habitat is warm, dry areas with little vegetation. O. martensii can grow to about 6 centimetres (2.4 in) long, with females usually slightly larger, and has a life-span of about 4 to 6 years.

Ikitoxin is a neurotoxin from the venom of the South African Spitting scorpion that targets voltage-sensitive sodium channels. It causes unprovoked jumps in mice following intracerebroventricular injections.

Ergtoxin is a toxin from the venom of the Mexican scorpion Centruroides noxius. This toxin targets hERG potassium channels.

BotIT2 is a neurotoxin from the scorpion Buthus occitanus tunetanus, which modifies activation and slows down the deactivation of voltage gated sodium channels.

TsIV is a toxin from the venom of the Brazilian scorpion Tityus serrulatus which slows the inactivation of sodium channels.

<span class="mw-page-title-main">Cll1</span> Scorpion protein

Toxin Cll1 is a toxin from the venom of the Mexican scorpion Centruroides limpidus limpidus, which changes the activation threshold of sodium channels by binding to neurotoxin binding site 4, resulting in increased excitability.

Centruroides suffusus suffusus toxin II (CssII) is a scorpion β-toxin from the venom of the scorpion Centruroides suffusus suffusus. CssII primarily affects voltage-gated sodium channels by causing a hyperpolarizing shift of voltage dependence, a reduction in peak transient current, and the occurrence of resurgent currents.

Pi4 is a short toxin from the scorpion Pandinus imperator that blocks specific potassium channels.

<span class="mw-page-title-main">Noxiustoxin</span>

Noxiustoxin (NTX) is a toxin from the venom of the Mexican scorpion Centruroides noxius Hoffmann which block voltage-dependent potassium channels and calcium-activated potassium channels.

Beta-mammal toxin Cn2, also known as Cn2 toxin, is a single chain β-scorpion neurotoxic peptide and the primary toxin in the venom of the Centruroides noxius Hoffmann scorpion. The toxin specifically targets mammalian Nav1.6 voltage-gated sodium channels (VGSC).

Beta-toxin Cll2, shortened to Cll2, is a toxin in the venom of the Mexican Scorpion species Centruroides limpidus limpidus. The toxin belongs to the β-class family of sodium channel-inhibiting scorpion toxins. It affects voltage-dependent activation, conductance and resurgent currents of voltage gated sodium channels by binding to site 4.

Intrepicalcin (ViCaTx1) is a short peptide toxin found in the venom of scorpion Vaejovis intrepidus. It is one of a group of short, basic peptides called calcins, which bind to ryanodine receptors (RyRs) and thereby trigger calcium release from the sarcoplasmic reticulum.

Centruroides noxius is a species of scorpion native to Mexico.

<span class="mw-page-title-main">Tst26</span>

The Tst26 toxin is a voltage-gated potassium channel blocker present in the venom of Tityus stigmurus, a species of Brazilian scorpion. Tst26 selectively blocks Kv1.2 and Kv1.3 channels.

The CmERG1 toxin is a peptide composed of 42 amino acids, found in venom from the Colombian scorpion Centruroides margaritatus. It blocks human ether-a-go-go-Related gene (hERG) potassium channels, which are important for cardiac action potential repolarization.

References

  1. "Genus Centruroides Marx,1890". Mes Scorpions. 26 October 2005. Retrieved 8 August 2013.
  2. "Centruroides baergi". ZipcodeZoo.com. 4 August 2012. Archived from the original on 9 August 2013. Retrieved 8 August 2013.
  3. Santibáñez-López, Carlos E.; Ponce-Saavedra, Javier (2009-08-01). "A new species of Centruroides (Scorpiones: Buthidae) from the northern mountain range of Oaxaca, Mexico Una especie nueva de Centruroides (Scorpiones: Buthidae) de la sierra norte de Oaxaca, México". Revista Mexicana de Biodiversidad. 80 (2): 321–331. doi: 10.22201/ib.20078706e.2009.002.619 . ISSN   1870-3453.
  4. 1 2 Cruz, Ibet S. (2014). "Distribución del Género Centruroides (Scorpionida: Buthidae) en el Estado de Oaxaca" [Distribution of Centruroides Gender (Scorpionida: Buthidae) in Oaxaca State](PDF). Revista Mexicana de Agroecosistemas (in Spanish). 1 (2): 121–131.
  5. 1 2 Gómez-Ramírez, Ilse V.; Riaño-Umbarila, Lidia; Olamendi-Portugal, Timoteo; Restano-Cassulini, Rita; Possani, Lourival D.; Becerril, Baltazar (2020-09-01). "Biochemical, electrophysiological and immunological characterization of the venom from Centruroides baergi, a new scorpion species of medical importance in Mexico". Toxicon. 184: 10–18. doi:10.1016/j.toxicon.2020.05.021. ISSN   0041-0101. PMID   32479835. S2CID   219170607.
  6. Wang, Jun; Ou, Shao-Wu; Wang, Yun-Jie (2017-11-08). "Distribution and function of voltage-gated sodium channels in the nervous system". Channels. 11 (6): 534–554. doi:10.1080/19336950.2017.1380758. ISSN   1933-6950. PMC   5786190 . PMID   28922053.
  7. Shamoon, Zafar; Peterfy, Ryan J.; Hammoud, Sami; Khazaeni, Babak (2022), "Scorpion Toxicity", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID   28613678 , retrieved 2022-04-21
  8. Olamendi-Portugal, Timoteo; Restano-Cassulini, Rita; Riaño-Umbarila, Lidia; Becerril, Baltazar; Possani, Lourival D. (2017-01-01). "Functional and immuno-reactive characterization of a previously undescribed peptide from the venom of the scorpion Centruroides limpidus". Peptides. 87: 34–40. doi:10.1016/j.peptides.2016.11.008. ISSN   0196-9781. PMID   27871874. S2CID   26098671.
  9. García-Guerrero, I. A.; Cárcamo-Noriega, E.; Gómez-Lagunas, F.; González-Santillán, E.; Zamudio, F. Z.; Gurrola, G. B.; Possani, L. D. (2020-01-15). "Biochemical characterization of the venom from the Mexican scorpion Centruroides ornatus, a dangerous species to humans". Toxicon. 173: 27–38. doi:10.1016/j.toxicon.2019.11.004. ISSN   0041-0101. PMID   31734253. S2CID   208141758.