U.S. Route 19 or U.S. Highway 19 (US 19) is a north–south United States Numbered Highway in the Eastern United States. Despite encroaching Interstate Highways, the route has remained a long-haul road, connecting the Gulf of Mexico with Lake Erie.
U.S. Route 58 is an east–west U.S. Highway that runs for 508 miles (818 km) from U.S. Route 25E just northwest of Harrogate, Tennessee, to U.S. Route 60 in Virginia Beach, Virginia. Until 1996, when the Cumberland Gap Tunnel opened, US 58 ran only inside the commonwealth of Virginia. It was then extended southwest along a short piece of former US 25E, which no longer enters Virginia, to end at the new alignment in Tennessee. For most of its alignment, it closely parallels Virginia's southern border with North Carolina.
U.S. Route 119 (US 119) is a spur of US 19. It is a north–south route that was an original United States highway of 1926. It is Corridor G of the Appalachian Development Highway System (ADHS) east of US 23 and KY 80 in Kentucky to Interstate 64 at Charleston, West Virginia.
U.S. Route 340 is a spur route of US 40, and runs from Greenville, Virginia, to Frederick, Maryland. In Virginia, it runs north–south, parallel and east of US 11, from US 11 north of Greenville via Waynesboro, Grottoes, Elkton, Luray, Front Royal, and Berryville to the West Virginia state line. A short separate piece crosses northern Loudoun County on its way from West Virginia to Maryland.
U.S. Route 460 (US 460) is a spur route of U.S. Route 60. It currently runs for 655 miles (1,054 km) from Norfolk, Virginia, at its parent route U.S. Route 60 at Ocean View to Frankfort, Kentucky, intersecting its parent route once again. It passes through the states of Virginia, West Virginia, and Kentucky. It goes through the cities and towns of Norfolk, Portsmouth, Suffolk, Petersburg, Farmville, Lynchburg, Roanoke, Christiansburg, Blacksburg, Tazewell, and Grundy, in Virginia; Princeton and Bluefield in West Virginia; and Pikeville, Georgetown, and Frankfort in Kentucky.
U.S. Route 48 (US 48), also known as the incomplete Corridor H of the Appalachian Development Highway System, extends from Interstate 79 (I-79) in Weston, West Virginia, eastward across the crest of the Allegheny Mountains to I-81 in Strasburg, Virginia. It is planned to extend 157 miles (253 km) from northwestern Virginia to central West Virginia.
In the United States, Corridor D is part of the Appalachian Development Highway System. In Ohio, it follows State Route 32 from the eastern Cincinnati suburbs until a point west of Albany, where it becomes concurrent with U.S. Route 50. After crossing into West Virginia, it follows U.S. Route 50 until the Interstate 79 interchange in Clarksburg.
New Circle Road, also known as Kentucky Route 4, is a Kentucky state highway that serves as an inner beltway around Lexington, which is part of the consolidated city-county government with Fayette County.
State Route 412 is a primary state highway in the U.S. state of Virginia. Known as Prices Fork Road, the state highway runs 1.35 miles (2.17 km) from U.S. Route 460 east to US 460 Business within Blacksburg in northern Montgomery County. SR 412 connects US 460 with downtown Blacksburg and the northern end of the campus of Virginia Tech.
State Route 114 is a primary state highway in the U.S. state of Virginia. Known as Peppers Ferry Road, the state highway runs 10.32 miles (16.61 km) from U.S. Route 11 in Fairlawn east to US 460 in Christiansburg. SR 114 is the northernmost of three east–west highways between Radford and Christiansburg and the most direct highway between Radford and Blacksburg. The state highway also connects those cities with the Radford Army Ammunition Plant.
Virginia State Route 311 and West Virginia Route 311 are adjoining state highways in the U.S. states of Virginia and West Virginia. The two state highways together run 58.7 miles (94.5 km) from U.S. Route 11 in Salem, Virginia north to Interstate 64 and U.S. Route 60 near White Sulphur Springs, West Virginia. The two Virginia portions of Route 311 are maintained by the Virginia Department of Transportation, with the exception of the city-maintained portion within Salem. The West Virginia segments are maintained by the West Virginia Division of Highways.
State Route 117 is a state highway in the U.S. state of Virginia. Known as Peters Creek Road, the state highway runs 7.21 miles (11.60 km) from U.S. Route 11 in Roanoke north to US 11 in Hollins. SR 117 provides a four-lane divided highway bypass of Downtown Roanoke, connecting US 11 and US 460 on the southwest and northwest sides of Roanoke and Hollins in northeastern Roanoke County.
U.S. Route 25E (US 25E) is the eastern branch of US 25 from Newport, Tennessee, where US 25 splits into US 25E and US 25W, to North Corbin, Kentucky, where the two highways rejoin. The highway, however, continues as US 25E for roughly two miles (3.2 km) until it joins Interstate 75 (I-75) in the Laurel County community of North Corbin at exit 29. The highway serves the Appalachia regions of Kentucky's Cumberland Plateau and the Ridge-and-Valley section of East Tennessee, including the urbanized areas of Corbin and Middlesboro in Kentucky and Morristown in Tennessee.
U.S. Route 52 (US 52) skirts the western fringes of the U.S. state of West Virginia. It runs from the Virginia state line near Bluefield, where it is concurrent with Interstate 77 (I-77), in a general northwest and north direction to I-64 at Kenova. There it turns east, overlapping I-64 for five miles (8.0 km) before splitting off onto the West Huntington Expressway into Ohio via the West Huntington Bridge. Despite having an even number, US 52 is signed north–south in West Virginia. In some other states along its route, it is signed east-west. The West Virginia segment is signed such that US 52 north corresponds to the general westward direction of the highway, and vice versa. For a while, US 52 parallels US 23, which is on the other side of the Big Sandy River in Kentucky. This continues into Ohio, where US 52 travels on the Ohio side of the Ohio River while US 23 travels on the Kentucky side.
Kentucky Route 11 (KY 11) is an American highway maintained by the Kentucky Transportation Cabinet that runs from Maysville to Barbourville. The route from Maysville to Mount Sterling is being upgraded on a new alignment as part of a "macro-corridor" within the state of Kentucky.
U.S. Route 460 (US 460) in Virginia runs west-east through the southern part of the Commonwealth. The road has two separate pieces in Virginia, joined by a relatively short section in West Virginia. Most of US 460 is a four-lane divided highway and is a major artery in the southern third of the state. From Petersburg to Suffolk, US 460 is a four-lane non-divided highway. It is a popular alternative to Interstate 64 (I-64) when going from Richmond and other points in central Virginia to the Currituck Sound and Outer Banks of North Carolina, avoiding the congestion and tunnels of the more northerly I-64 corridor. The road passes through several small towns that built up at stops along the railroad line.
U.S. Route 19 (US 19) is a part of the United States Numbered Highway System that runs from Memphis, Florida, to Erie, Pennsylvania. In Virginia, the highway runs 88.89 miles (143.05 km) between two pairs of twin cities: Bristol, Tennessee, and Bristol, Virginia, at the Virginia–Tennessee state line, and Bluefield, Virginia, and Bluefield, West Virginia, at the Virginia–West Virginia state line. Between its endpoints, US 19 has lengthy concurrencies with US 11, US 58 Alternate, and US 460 during its course connecting Abingdon, Lebanon, and Tazewell within Washington, Russell, and Tazewell counties in Southwest Virginia.
State Route 8 is a primary state highway in the U.S. state of Virginia. The state highway runs 55.88 miles (89.93 km) from the North Carolina state line near Palmetto, where the highway continues south as North Carolina Highway 8, north to U.S. Route 11 in Christiansburg. SR 8 is part of a 151-mile (243 km) two-state highway 8 system and is the main north–south highway of Patrick County, Floyd County, and southern Montgomery County, connecting their respective county seats of Stuart, Floyd, and Christiansburg with each other and with the Blue Ridge Parkway. The state highway also links the New River Valley region of Virginia with Southside Virginia via US 58 and the Piedmont Triad of North Carolina via NC 8.
Virginia State Route 102 and West Virginia Route 102 are adjoining state highways in the U.S. states of Virginia and West Virginia. The two state highways together run 11.4 miles (18.3 km) from Center Street in Pocahontas, Virginia east to the Virginia – West Virginia state line between the twin cities of Bluefield, Virginia and Bluefield, West Virginia. Most of Route 102 consists of three sections in Virginia maintained by the Virginia Department of Transportation (VDOT); the two intervening sections in West Virginia are maintained by the West Virginia Division of Highways. In addition to connecting Pocahontas with the two Bluefields, the state highway passes through Nemours, West Virginia and Falls Mills, Virginia and provides access to Bluefield College.
A total of at least sixteen special routes of U.S. Route 460 exist and at least six have been deleted.
US 23 / US 119 (Corr. B) near Pikeville, KY 
US 19 near Richlands, VA 
US 52 in Bluefield, WV 
I-77 near Princeton, WV 
I-81 in Christiansburg, VA 
