Difetarsone

Last updated
Difetarsone
Difetarsone.svg
Difetarsone molecule spacefill.png
Clinical data
ATC code
Identifiers
  • [4-[2-[(4-arsonophenyl)amino]ethylamino]phenyl] arsonic acid
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard 100.020.788 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C14H18As2N2O6
Molar mass 460.149 g·mol−1

Difetarsone is an antiprotozoal agent. Various studies have shown it to be particularly effective against Trichuris trichiura , commonly known as the whipworm. Prior to the drugs use in the early 1970s, there were few effective treatments for this infection. [1] It has also been used to treat Entamoeba histolytica infections. [2]

Difetarsone often has minor side effects, which include rashes, nausea and vomiting. It has also resulted in angioedema in at least one known case. [2]

References

  1. Leary PM, Jones C, Douglas F, Boyd ST (June 1974). "Difetarsone in outpatient treatment of Trichuris trichiura infestation". Archives of Disease in Childhood. 49 (6): 486–8. doi:10.1136/adc.49.6.486. PMC   1648795 . PMID   4851370.
  2. 1 2 Aronson JK (2009). Meyler's Side Effects of Antimicrobial Drugs. p. 834. ISBN   9780080932934 . Retrieved October 7, 2013.