Dimitri Kullmann

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Dimitri Kullmann

Dimitri Kullmann Royal Society.jpg
Dimitri Kullmann at the Royal Society, London, 2018
Born
Dimitri Michael Kullmann

1958 (age 6566) [1]
London, England [1]
Education Lycée Français Charles de Gaulle [1]
Alma mater University of Oxford (BM BCh, DPhil)
Awards Baly Medal (2017) [2]
Scientific career
Fields
Institutions
Thesis Central actions of muscle receptors  (1984)
Doctoral advisor Julian Jack [4]
Website www.ucl.ac.uk/ion/research/synaptopathies/principal-investigators/dimitri-m-kullmann

Dimitri Michael Kullmann (born 1958) [1] FRS FMedSci MAE is a professor of neurology at the UCL Institute of Neurology, [2] University College London (UCL), and leads the synaptopathies initiative funded by the Wellcome Trust. [5] Kullmann is a member of the Queen Square Institute of Neurology Department of Clinical and Experimental Epilepsy [6] and a consultant neurologist at the National Hospital for Neurology and Neurosurgery. [3] [7]

Contents

Education

Kullmann was educated at the Lycée Français Charles de Gaulle [1] and studied physiology at Balliol College, Oxford [1] where he was awarded a Bachelor of Arts (BA) degree and a Doctor of Philosophy degree. [4] He studied and trained at the University of Oxford and St Thomas's Hospital Medical School at the University of London. [2] His postgraduate research was supervised by Julian Jack. [4]

Research and career

Kullmann's research [3] [7] investigates how synapses function in health and disease. [8] His laboratory helped to show how neurotransmitters activate different receptor subtypes in and around synapses, and resolved some controversies about the mechanisms of long-term changes in synaptic strength. [8] Genetic and autoimmune disorders of synaptic proteins (‘synaptopathies’) provide insights into the mechanisms of a broad range of neurological diseases including epilepsy and migraine. [8] Together with his colleagues, Kullmann has used these insights to devise gene therapy strategies that could be used to treat intractable epilepsy. [8] [3]

The Kullmann lab [3] [7] has contributed to the discovery and elucidation of silent synapses, [9] glutamate spillover, tonic inhibition, [10] long-term potentiation in interneurons, [11] neurological channelopathies [12] and Synaptopathies, gene therapy for epilepsy, [13] and mechanisms of neural oscillations. [14] Kullmann served as the editor-in-chief of the scientific journal Brain between 2014 and 2020 [15] and is on the editorial board of the journal Neuron . [16] Before working at UCL, he did postdoctoral research with Roger Nicoll at the University of California, San Francisco. [2]

Awards and honours

Kullmann was awarded the University Gold Medal in Medicine by the University of London, in 1986. [2] and the Baly Medal by the Royal College of Physicians in 2017. [2] He was elected a Guarantor of Brain in 2000, [17] elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2001, [18] a Corresponding Fellow of the American Neurological Association in 2013, [19] a member of the Academia Europaea (MAE) in 2017 [20] and a Fellow of the Royal Society (FRS) in 2018. [8]

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References

  1. 1 2 3 4 5 6 Anon (2019). "Kullmann, Prof. Dimitri Michael" . Who's Who (online Oxford University Press  ed.). Oxford: A & C Black.(Subscription or UK public library membership required.)
  2. 1 2 3 4 5 6 7 "Prof Dimitri Michael Kullmann: Iris View Profile". University College London. Retrieved 2 October 2016.
  3. 1 2 3 4 5 6 7 8 Dimitri Kullmann publications indexed by Google Scholar OOjs UI icon edit-ltr-progressive.svg
  4. 1 2 3 Kullman, Dimitri Michael (1984). Central actions of muscle receptors (DPhil thesis). University of Oxford. OCLC   59330270. EThOS   uk.bl.ethos.353099. Archived from the original on 16 December 2019. Retrieved 6 June 2018.
  5. "Synaptopathies". University College London. 17 July 2014. Retrieved 2 October 2016.
  6. "DCEE". University College London. 29 May 2020. Retrieved 7 June 2021.
  7. 1 2 3 Dimitri Kullmann publications from Europe PubMed Central
  8. 1 2 3 4 5 Anon (2018). "Professor Dimitri Kullmann FMedSci FRS". royalsociety.org. London: Royal Society. Archived from the original on 24 May 2018. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    "All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
  9. Kullmann, Dimitri M. (1994). "Amplitude fluctuations of". Neuron. 12 (5): 1111–1120. doi:10.1016/0896-6273(94)90318-2. PMID   7910467. S2CID   54357872.
  10. Semyanov, Alexey; Walker, Matthew C.; Kullmann, Dimitri M.; Silver, R.Angus (2004). "Tonically active GABAA receptors: modulating gain and maintaining the tone". Trends in Neurosciences. 27 (5): 262–269. doi:10.1016/j.tins.2004.03.005. ISSN   0166-2236. PMID   15111008. S2CID   2660172.
  11. Lamsa, Karri P.; Heeroma, Joost H.; Somogyi, Peter; Rusakov, Dmitri A.; Kullmann, Dimitri M. (2007). "Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit". Science. 315 (5816): 1262–1266. Bibcode:2007Sci...315.1262L. doi:10.1126/science.1137450. ISSN   1095-9203. PMC   3369266 . PMID   17332410.
  12. Kullmann, Dimitri M. (2010). "Neurological channelopathies". Annual Review of Neuroscience. 33: 151–172. doi:10.1146/annurev-neuro-060909-153122. ISSN   1545-4126. PMID   20331364.
  13. Wykes, Robert C.; Heeroma, Joost H.; Mantoan, Laura; Zheng, Kaiyu; MacDonald, Douglas C.; Deisseroth, Karl; Hashemi, Kevan S.; Walker, Matthew C.; Schorge, Stephanie (2012). "Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy". Science Translational Medicine. 4 (161): 161ra152. doi:10.1126/scitranslmed.3004190. ISSN   1946-6242. PMC   3605784 . PMID   23147003.
  14. Akam, Thomas; Oren, Iris; Mantoan, Laura; Ferenczi, Emily; Kullmann, Dimitri M. (2012). "Oscillatory dynamics in the hippocampus support dentate gyrus–CA3 coupling". Nature Neuroscience . 15 (5): 763–768. doi:10.1038/nn.3081. ISSN   1546-1726. PMC   3378654 . PMID   22466505.
  15. "Editorial board | Brain". Brain.oxfordjournals.org. 26 September 2016. Archived from the original on 11 October 2014. Retrieved 2 October 2016.
  16. "Editorial Board: Neuron". cell.com.
  17. "Guarantors of Brain". Guarantors of Brain. Retrieved 11 August 2016.
  18. "Professor Dimitri Kullmann FMedSci". acmedsci.ac.uk. Retrieved 2 October 2016.
  19. "American Neurological Association (ANA)". Myana.org. Retrieved 1 November 2016.
  20. Hoffmann, Ilire Hasani, Robert. "Academy of Europe: Kullmann Dimitri". ae-info.org.{{cite web}}: CS1 maint: multiple names: authors list (link)

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