ERp27

ERP27
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L4C, 4F9Z
Identifiers
Aliases	ERP27 , C12orf46, PDIA8, endoplasmic reticulum protein 27
External IDs	OMIM: 610642; MGI: 1916437; HomoloGene: 12303; GeneCards: ERP27; OMA:ERP27 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p12.3 Start 14,914,039 bp [1] End 14,938,537 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 G1 Start 136,884,309 bp [2] End 136,899,178 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas pancreatic epithelial cell right uterine tube tibialis anterior muscle islet of Langerhans human kidney gonad mucosa of ileum urinary bladder granulocyte Top expressed in pancreas granulocyte islet of Langerhans embryo stomach duodenum thymus mesenteric lymph nodes migratory enteric neural crest cell gastrula More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protein disulfide isomerase activity peptidyl-proline 4-dioxygenase activity Cellular component endoplasmic reticulum lumen endoplasmic reticulum Biological process protein folding response to endoplasmic reticulum stress peptidyl-proline hydroxylation regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 121506 69187 Ensembl ENSG00000139055 ENSMUSG00000030219 UniProt Q96DN0 Q9D8U3 RefSeq (mRNA) NM_152321 NM_001300784 NM_026983 RefSeq (protein) NP_001287713 NP_689534 NP_081259 Location (UCSC) Chr 12: 14.91 – 14.94 Mb Chr 6: 136.88 – 136.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Endoplasmic reticulum resident protein 27 is a protein that in humans is encoded by the ERP27 gene. It is a homologue of PDI (protein disulfide-isomerase), localised to the Endoplasmic Reticulum. The structure of ERp27 has been solved by both X-ray crystallography and NMR spectroscopy, ^[5] showing it to be composed of two thioredoxin-like domains with homology to the non-catalytic b and b' domains of PDI. The function of ERp27 is unknown, but on the basis of its homology with PDI it is thought to possess chaperone activity. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000139055 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030219 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Amin NT, Wallis AK, Wells SA, Rowe ML, Williamson RA, Howard MJ, et al. (March 2013). "High-resolution NMR studies of structure and dynamics of human ERp27 indicate extensive interdomain flexibility". The Biochemical Journal. 450 (2): 321–332. doi:10.1042/BJ20121635. PMC   4203274 . PMID   23234573.
6. Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (1) 6. doi: 10.1186/1479-7364-6-6 . PMC   3500226 . PMID   23245351.