Effect of oxygen on chronic obstructive pulmonary disease

In some individuals, the effect of oxygen on chronic obstructive pulmonary disease (COPD) is to cause increased carbon dioxide retention.

Signs and symptoms

In individuals with chronic obstructive pulmonary disease and similar lung problems, the clinical features of excessive oxygen administration are due to high carbon dioxide content in the blood (hypercapnia). ^[1] Increasing levels of carbon dioxide in the blood leads to decreased consciousness, deranged acid-base balance due to respiratory acidosis, and death. ^{[2] [3]}

Causes

Many people with chronic obstructive pulmonary disease have a low partial pressure of oxygen (PaO₂) in the blood and high partial pressure of carbon dioxide (PaCO₂). Treatment with supplemental oxygen may improve their well-being; alternatively, in some this can lead to the adverse effect of elevating the carbon dioxide content in the blood (hypercapnia) to levels that may become toxic. ^{[4] [5]} The two main contributors to this increase in PaCO₂ are ventilation–perfusion mismatch and the Haldane effect. ^{[6] [3] [7]}

• Ventilation/perfusion mismatch: under-ventilated lung usually has a low oxygen content which leads to localized vasoconstriction limiting blood flow to that lung tissue. Supplemental oxygen abolishes this constriction, leading to alveoli with relatively poor ventilation being well-perfused. This mismatch leads to a redistribution of blood to areas of the lung with poor ventilation, reducing the amount of carbon dioxide eliminated from the system.

• The Haldane effect: most carbon dioxide is carried by the blood as bicarbonate (HCO−3), and deoxygenated hemoglobin promotes the production of bicarbonate. Increasing the amount of oxygen in the blood by administering supplemental oxygen reduces the amount of deoxygenated hemoglobin, and thus reduces the capacity of blood to carry carbon dioxide.

Historically, it was believed that oxygen-induced hypercapnia in COPD resulted from the 'hypoxic drive' mechanism. ^{[3] [7]} Normally, the stimulation to take another breath occurs primarily from a slight rise in PaCO₂. The slight rise in PaCO₂ stimulates the respiratory centre in the brain, creating the impulse to take another breath. In some patients with a chronically high level of PaCO₂, such as those with COPD, the stimulus and drive to breathe from increased PaCO₂ is diminished, and contribution of PaO₂ to stimulate breathing becomes more significant. Thus, when oxygen is administered to patients with known CO₂ retention, a minute decrease in ventilation can occur, contributing to increased PaCO₂. ^[8] While historically a decrease in minute ventilation was considered the main driver of oxygen-induced hypercapnia in COPD, it is now known to be the smallest of the contributors to increases in PaCO₂. ^{[3] [7]}

Prevention

In people with chronic obstructive pulmonary disease, carbon dioxide toxicity can be prevented by careful control of the supplemental oxygen. In those with an acute exacerbation of COPD, hypoxic pulmonary vasoconstriction can improve gas exchange, and so just enough oxygen is given to maintain an oxygen saturation of 88%–92%. ^{[9] [7]}

References

1. Tinits, P (1983). "Oxygen therapy and oxygen toxicity". Annals of Emergency Medicine. 12 (5): 321–8. doi:10.1016/S0196-0644(83)80520-4. PMID   6414343.
2. Young, IH (2007). "Revisiting oxygen therapy in patients with exacerbation of chronic obstructive pulmonary disease" . The Medical Journal of Australia. 186 (5): 239. doi:10.5694/j.1326-5377.2007.tb00880.x. PMID   17391085. S2CID   27365725.
3. Drechsler, Michael; Morris, Jason (9 January 2023). "Carbon Dioxide Narcosis". Carbon Dioxide Narcosis. StatPearls Publishing.
4. Kim, V; Benditt, JO; Wise, RA; Sharafkhaneh, A (2008). "Oxygen therapy in chronic obstructive pulmonary disease". Proceedings of the American Thoracic Society. 5 (4): 513–8. doi:10.1513/pats.200708-124ET. PMC   2645328 . PMID   18453364.
5. Patel, Dharmeshkumar N; Goel, Ashish; Agarwal, SB; Garg, Praveenkumar; Lakhani, Krishna K (2003). "Oxygen toxicity" (PDF). Journal, Indian Academy of Clinical Medicine. 4 (3): 234–7. Archived from the original (PDF) on 2015-09-22. Retrieved 2008-09-28.
6. Lumb, AB (2000). Nunn's Applied Respiratory Physiology (5th ed.). Butterworth Heinemann. p. 533. ISBN   0-7506-3107-4.
7. Abdo, Wilson F; Heunks, Leo MA (October 2012). "Oxygen-induced hypercapnia in COPD: myths and facts". Critical Care. 16 (5): 323. doi: 10.1186/cc11475 . PMC   3682248 . PMID   23106947.
8. Doyle, Glynda Rees; McCutcheon, Jodie Anita (2015-11-23). "5.7 Cautions with Oxygen Therapy". Clinical Procedures for Safer Patient Care.
9. "2025 GOLD Report". Global Initiative for Chronic Obstructive Lung Disease - GOLD.