Efloxate

Efloxate
Clinical data
ATC code	C01DX13 ( WHO );
Identifiers
	IUPAC name ethyl 2-[(4-oxo-2-phenyl-4H-chromen-7-yl)oxy]acetate;
CAS Number	119-41-5 ;
PubChem CID	8395 ;
ChemSpider	8089 ;
UNII	CZU6V3902K ;
ChEMBL	ChEMBL1349073 ;
CompTox Dashboard (EPA)	DTXSID3048736 ;
ECHA InfoCard	100.003.929
Chemical and physical data
Formula	C19H16O5
Molar mass	324.332 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES CCOC(=O)COc1ccc2c(=O)cc(oc2c1)c3ccccc3;
	InChI InChI=1S/C19H16O5/c1-2-22-19(21)12-23-14-8-9-15-16(20)11-17(24-18(15)10-14)13-6-4-3-5-7-13/h3-11H,2,12H2,1H3; Key:ZVXBAHLOGZCFTP-UHFFFAOYSA-N;
	(verify)

Last updated January 29, 2023

Efloxate is a vasodilator.^[1]

Related Research Articles

<span class="mw-page-title-main">Khellin</span> Chemical compound

Khellin has been used as an herbal folk medicine, with use in the Mediterranean dating back to Ancient Egypt, to treat a variety of maladies including: renal colic, kidney stones, coronary disease, bronchial asthma, vitiligo, and psoriasis. It is a major constituent of the plant Ammi visnaga, also known as Bishop's Weed. Once purified, khellin exists as colorless, odorless, bitter-tasting needle-shaped crystals and is classified as a gamma-pyrone, a furanochromone derivative. In the early 20th century, researchers searched for khellin analogs with lower toxicity and better efficacy. A number of drugs were discovered through this research, such as amiodarone and cromolyn sodium, which are used in current medical practice. Efloxate is also mentioned as analog.

References

↑ Tomasi AM, Masoni A (August 1977). "[Clinical research on the therapeutic efficacy and tolerance of long-acting efloxate in angina pectoris]". La Clinica Terapeutica (in Italian). 82 (3): 227–41. PMID 334448.

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[Tomasi_1977-1] Tomasi AM, Masoni A (August 1977). "[Clinical research on the therapeutic efficacy and tolerance of long-acting efloxate in angina pectoris]". La Clinica Terapeutica (in Italian). 82 (3): 227–41. PMID 334448.

[1]

v t e Vasodilators used in cardiac diseases (C01D)
Nitrovasodilators	Nitroglycerin # Isosorbide dinitrate # Isosorbide mononitrate Itramin tosilate Linsidomine Molsidomine Nicorandil Pentaerythritol tetranitrate Propatylnitrate Tenitramine Trolnitrate
Quinolone vasodilators	Flosequinan ^‡
Others	Benziodarone Carbocromen Cinepazet Cloridarol Dilazep Efloxate Etafenone Gapicomine Heptaminol Hexobendine Imolamine Levosimendan Nesiritide Nicorandil Oxyfedrine Pimobendan Prenylamine Serelaxin Trapidil Vericiguat
^# WHO-EM ^‡ Withdrawn from market Clinical trials: ^† Phase III ^§Never to phase III

Clinical data

ATC code	C01DX13 ( WHO )
Identifiers
IUPAC name ethyl 2-[(4-oxo-2-phenyl-4H-chromen-7-yl)oxy]acetate
CAS Number	119-41-5 ^Y
PubChem CID	8395
ChemSpider	8089
UNII	CZU6V3902K
ChEMBL	ChEMBL1349073
CompTox Dashboard (EPA)	DTXSID3048736
ECHA InfoCard	100.003.929
Chemical and physical data
Formula	C₁₉H₁₆O₅
Molar mass	324.332 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCOC(=O)COc1ccc2c(=O)cc(oc2c1)c3ccccc3
InChI InChI=1S/C19H16O5/c1-2-22-19(21)12-23-14-8-9-15-16(20)11-17(24-18(15)10-14)13-6-4-3-5-7-13/h3-11H,2,12H2,1H3 Key:ZVXBAHLOGZCFTP-UHFFFAOYSA-N
(verify)