Erich Bornberg-Bauer

Last updated
Erich Bornberg-Bauer
Born1963 (age 61–62)
Vienna, Austria
NationalityAustrian
Alma mater University of Vienna
Known for
AwardsMember Faculty of 1000
Scientific career
Fields
Institutions
Doctoral advisor Prof. Peter Schuster
Website bornberglab.org

Erich Bornberg-Bauer (born 1963 in Vienna) is an Austrian biochemist, theoretical biologist and bioinformatician.

Contents

Life

Bornberg-Bauer studied biochemistry, physics and mathematics (1981–1991) at the University of Vienna and obtained a diploma in biochemistry (1992). He performed his doctoral research on evolutionary fitness landscapes of RNA and proteins in the group of Peter Schuster, Institute of Theoretical Chemistry, University of Vienna, and received his Ph.D in 1995. [2] He continued his academic career at the University of Vienna (Institute of Mathematics) as a university assistant (equivalent to assistant professor; 1994 – 1996). Thereafter, he worked at the Deutsche Krebsforschungszentrum in Heidelberg as a postdoctoral researcher in the group of Martin Vingron on algorithms for sequence analysis (1996–1998), and subsequently as a project leader at EML (European Media Laboratory) GmbH (1998 – 2000; this department is now a part of Heidelberg Institute for Theoretical Studies). Since 2000, Bornberg-Bauer has been working as an independent academic researcher, first as a senior lecturer in bioinformatics at the University of Manchester (2000–2003), and then as a professor of Molecular Evolution and Bioinformatics at the Institute for Evolution and Biodiversity, University of Münster (2003 – present). [2] Since 2018, he is a guest scientist at the Max Planck Institute for Biology in Tübingen. [3] He has been a guest professor at Claude Bernard University Lyon 1 and a visiting scholar at European Bioinformatics Institute.

Research

Bornberg-Bauer's earlier research focused on the aspects of RNA and protein evolution, especially on the phenomenon of neutral evolution, evolvability and robustness. Together with Hue Sun Chan (University of Toronto), [4] he developed the concept of superfunnels on neutral networks, which describes how populations of functional polymers (such as proteins) randomly explore the sequence space to find transition sequences (switches) to new networks. [5] [6] [7] His work also showed that errors in a protein's sequence that arise during translation (phenotypic mutations), help to explore the sequence space more rapidly. This phenomenon, termed as the look ahead effect, dramatically increases the probability of a gene to acquire beneficial double mutations. [8] His research group at the University of Münster has been working on three main research topics. First is (since 2005) modular evolution of proteins, which involves understanding of how protein domains can reshuffle to create new proteins with altered functions. [2] [9] [10] [11] [12] The second topic is about a phenomenon known as de novo gene birth by which new protein coding genes emerge from DNA segments in an organism's genome, that do not contain any genes. [13] [14] [15] [16] [17] [18] [19] [20] [21] The third topic is genomic analysis of the evolution of eusociality in insects. [22] [23] [24] [25] [26] [27] Bornberg-Bauer has been involved in the initial genome sequencing and annotation of Eucalyptus grandis , [28] Nasonia vitripennis , [29] Nasonia giraulti [29] , Nasonia longicornis , [29] Zostera marina , [30] Bombus terrestris, [31] Bombus impatiens, [31] Atta cephalotes, [32] Blattella germanica [33] and Cryptotermes secundus [33]

His earlier work and most research projects from his group, primarily involve bioinformatics and computational biology. Recent projects form his group have coupled theoretical findings with experiments to understand the molecular evolution of promiscuous (multifunctional) enzymes, [34] and the properties of proteins that emerge de novo. [35] Bornberg-Bauer's work has been supported by the German Research Foundation, the Volkswagen Foundation, the European Commission, and four research grants from the Human Frontier Science Program in 2006, 2013, 2018 and 2023, among others. [2] [36] Since 2021, Bornberg-Bauer is leading the research priority program, "The Genomic Basis of Evolutionary Innovations (GEvol)" of the German Research Foundation [37] [38] [39] He has been Editor-in-chief of Bioinformatics and Biology Insights [40] since 2009 and is editorial member of the Journal of the Royal Society Interface, [41] BMC Evolutionary Biology [42] and the Journal of Experimental Zoology. [43]

Publications

Erich Bornberg-Bauer has published more than 150 scientific articles and book chapters.

Scientific articles

Selected publications

References

  1. ↑ "Erich Bornberg-Bauer on Google Scholar". 28 February 2022.
  2. 1 2 3 4 "Website of Erich-Bornberg-Bauer". 28 February 2022.
  3. ↑ "MPI for Biology Tübingen, Department Protein Evolution". 28 February 2022.
  4. ↑ "Website of Hue Sun Chan". 2 March 2022.
  5. ↑ Bornberg-Bauer, E.; Chan, H. S. (1999-09-14). "Modeling evolutionary landscapes: Mutational stability, topology, and superfunnels in sequence space". Proceedings of the National Academy of Sciences. 96 (19): 10689–10694. Bibcode:1999PNAS...9610689B. doi: 10.1073/pnas.96.19.10689 . ISSN   0027-8424. PMC   17944 . PMID   10485887.
  6. ↑ Cui, Y.; Wong, W. H.; Bornberg-Bauer, E.; Chan, H. S. (2002-01-22). "Recombinatoric exploration of novel folded structures: A heteropolymer-based model of protein evolutionary landscapes". Proceedings of the National Academy of Sciences. 99 (2): 809–814. Bibcode:2002PNAS...99..809C. doi: 10.1073/pnas.022240299 . ISSN   0027-8424. PMC   117387 . PMID   11805332.
  7. ↑ Wroe, Richard; Chan, Hue Sun; Bornberg‐Bauer, Erich (2007-05-01). "A structural model of latent evolutionary potentials underlying neutral networks in proteins". HFSP Journal. 1 (1): 79–87. doi:10.2976/1.2739116/10.2976/1. ISSN   1955-2068. PMC   2645552 . PMID   19404462.
  8. ↑ Whitehead, Dion J.; Wilke, Claus O.; Vernazobres, David; Bornberg-Bauer, Erich (2008). "The look-ahead effect of phenotypic mutations". Biology Direct. 3: 18. doi: 10.1186/1745-6150-3-18 . PMC   2423361 . PMID   18479505.
  9. ↑ Bornberg-Bauer, Erich; Albà, M Mar (2013). "Dynamics and adaptive benefits of modular protein evolution" . Current Opinion in Structural Biology. 23 (3): 459–466. doi:10.1016/j.sbi.2013.02.012. PMID   23562500.
  10. ↑ Moore, Andrew D.; Björklund, Åsa K.; Ekman, Diana; Bornberg-Bauer, Erich; Elofsson, Arne (2008). "Arrangements in the modular evolution of proteins" . Trends in Biochemical Sciences. 33 (9): 444–451. doi:10.1016/j.tibs.2008.05.008. PMID   18656364.
  11. ↑ Moore, A. D.; Bornberg-Bauer, E. (2012). "The Dynamics and Evolutionary Potential of Domain Loss and Emergence". Molecular Biology and Evolution. pp. 787–796. doi:10.1093/molbev/msr250. PMC   3258042 . PMID   22016574.
  12. ↑ Bornberg-Bauer, E.; Beaussart, F.; Kummerfeld, S. K.; Teichmann, S. A.; Weiner, J. (2005). "The evolution of domain arrangements in proteins and interaction networks". Cellular and Molecular Life Sciences. 62 (4): 435–445. doi:10.1007/s00018-004-4416-1. PMC   11924419 . PMID   15719170. S2CID   14238792.
  13. ↑ "New proteins 'out of nothing'". EurekAlert. 28 February 2021.
  14. ↑ Bornberg-Bauer, Erich; Hlouchova, Klara; Lange, Andreas (2021-06-01). "Structure and function of naturally evolved de novo proteins" . Current Opinion in Structural Biology. Protein-Carbohydrate Complexes and Glycosylation ● Sequences and Topology. 68: 175–183. doi:10.1016/j.sbi.2020.11.010. ISSN   0959-440X. PMID   33567396. S2CID   231882733.
  15. ↑ Heames, Brennen; Schmitz, Jonathan; Bornberg-Bauer, Erich (2020-05-01). "A Continuum of Evolving De Novo Genes Drives Protein-Coding Novelty in Drosophila". Journal of Molecular Evolution. 88 (4): 382–398. Bibcode:2020JMolE..88..382H. doi:10.1007/s00239-020-09939-z. ISSN   1432-1432. PMC   7162840 . PMID   32253450.
  16. ↑ Rivard, Emily L.; Ludwig, Andrew G.; Patel, Prajal H.; Grandchamp, Anna; Arnold, Sarah E.; Berger, Alina; Scott, Emilie M.; Kelly, Brendan J.; Mascha, Grace C.; Bornberg-Bauer, Erich; Findlay, Geoffrey D. (2021-09-03). "A putative de novo evolved gene required for spermatid chromatin condensation in Drosophila melanogaster". PLOS Genetics. 17 (9): e1009787. doi: 10.1371/journal.pgen.1009787 . ISSN   1553-7404. PMC   8445463 . PMID   34478447.
  17. ↑ Gubala, A. M.; Schmitz, J. F.; Kearns, M. J.; Vinh, T. T.; Bornberg-Bauer, E.; Wolfner, M. F.; Findlay, G. D. (2017). "The goddard and saturn genes are essential for Drosophila male fertility and may have arisen de novo". Molecular Biology and Evolution. pp. 1066–1082. doi:10.1093/molbev/msx057. PMC   5400382 . PMID   28104747 . Retrieved 2022-03-02.
  18. ↑ Bornberg-Bauer, Erich; Huylmans, Ann-Kathrin; Sikosek, Tobias (2010-06-01). "How do new proteins arise?" . Current Opinion in Structural Biology. Nucleic acids / Sequences and topology. 20 (3): 390–396. doi:10.1016/j.sbi.2010.02.005. ISSN   0959-440X. PMID   20347587.
  19. ↑ Wissler, Lothar; Gadau, Jürgen; Simola, Daniel F.; Helmkampf, Martin; Bornberg-Bauer, Erich (2013). "Mechanisms and dynamics of orphan gene emergence in insect genomes". Genome Biology and Evolution. 5 (2): 439–455. doi:10.1093/gbe/evt009. ISSN   1759-6653. PMC   3590893 . PMID   23348040.
  20. ↑ Bitard-Feildel, Tristan; Heberlein, Magdalena; Bornberg-Bauer, Erich; Callebaut, Isabelle (2015-12-01). "Detection of orphan domains in Drosophila using "hydrophobic cluster analysis"" . Biochimie. 119: 244–253. doi:10.1016/j.biochi.2015.02.019. ISSN   0300-9084. PMID   25736992.
  21. ↑ "A Surprise Source of Life's Code". Scientific American. 3 March 2022.
  22. ↑ Terrapon, Nicolas; Li, Cai; Robertson, Hugh M.; Ji, Lu; Meng, Xuehong; Booth, Warren; Chen, Zhensheng; Childers, Christopher P.; Glastad, Karl M.; Gokhale, Kaustubh; Gowin, Johannes (2014-05-20). "Molecular traces of alternative social organization in a termite genome". Nature Communications. 5 (1): 3636. Bibcode:2014NatCo...5.3636T. doi:10.1038/ncomms4636. hdl: 2286/R.I.44873 . ISSN   2041-1723. PMID   24845553. S2CID   12087886.
  23. ↑ Jongepier, Evelien; Séguret, Alice; Labutin, Anton; Feldmeyer, Barbara; Gstöttl, Claudia; Foitzik, Susanne; Heinze, Jürgen; Bornberg-Bauer, Erich (2022-01-01). "Convergent Loss of Chemoreceptors across Independent Origins of Slave-Making in Ants". Molecular Biology and Evolution. 39 (1): msab305. doi:10.1093/molbev/msab305. ISSN   1537-1719. PMC   8760941 . PMID   34668533.
  24. ↑ Harrison, Mark C.; Jongepier, Evelien; Robertson, Hugh M.; Arning, Nicolas; Bitard-Feildel, Tristan; Chao, Hsu; Childers, Christopher P.; Dinh, Huyen; Doddapaneni, Harshavardhan; Dugan, Shannon; Gowin, Johannes (March 2018). "Hemimetabolous genomes reveal molecular basis of termite eusociality". Nature Ecology & Evolution. 2 (3): 557–566. doi:10.1038/s41559-017-0459-1. ISSN   2397-334X. PMC   6482461 . PMID   29403074.
  25. ↑ Harrison, Mark C; Niño, Luisa M Jaimes; Rodrigues, Marisa Almeida; Ryll, Judith; Flatt, Thomas; Oettler, Jan; Bornberg-Bauer, Erich (2021-06-01). "Gene Coexpression Network Reveals Highly Conserved, Well-Regulated Anti-Ageing Mechanisms in Old Ant Queens". Genome Biology and Evolution. 13 (6): evab093. doi:10.1093/gbe/evab093. ISSN   1759-6653. PMC   8214412 . PMID   33944936.
  26. ↑ "Ein Beispiel konvergenter Evolution" [An example of convergent evolution]. IDW (in German). 3 March 2022.
  27. ↑ "The social evolution of termites". Science Daily. 3 March 2022.
  28. ↑ Myburg, Alexander A.; Grattapaglia, Dario; Tuskan, Gerald A.; Hellsten, Uffe; Hayes, Richard D.; Grimwood, Jane; Jenkins, Jerry; Lindquist, Erika; Tice, Hope; Bauer, Diane; Goodstein, David M.; Dubchak, Inna; Poliakov, Alexandre; Mizrachi, Eshchar; Kullan, Anand R. K.; Hussey, Steven G.; Pinard, Desre; van der Merwe, Karen; Singh, Pooja; van Jaarsveld, Ida; Silva-Junior, Orzenil B.; Togawa, Roberto C.; Pappas, Marilia R.; Faria, Danielle A.; Sansaloni, Carolina P.; Petroli, Cesar D.; Yang, Xiaohan; Ranjan, Priya; Tschaplinski, Timothy J.; Ye, Chu-Yu; Li, Ting; Sterck, Lieven; Vanneste, Kevin; Murat, Florent; Soler, Marçal; Clemente, Hélène San; Saidi, Naijib; Cassan-Wang, Hua; Dunand, Christophe; Hefer, Charles A.; Bornberg-Bauer, Erich; Kersting, Anna R.; Vining, Kelly; Amarasinghe, Vindhya; Ranik, Martin; Naithani, Sushma; Elser, Justin; Boyd, Alexander E.; Liston, Aaron; Spatafora, Joseph W.; Dharmwardhana, Palitha; Raja, Rajani; Sullivan, Christopher; Romanel, Elisson; Alves-Ferreira, Marcio; Külheim, Carsten; Foley, William; Carocha, Victor; Paiva, Jorge; Kudrna, David; Brommonschenkel, Sergio H.; Pasquali, Giancarlo; Byrne, Margaret; Rigault, Philippe; Tibbits, Josquin; Spokevicius, Antanas; Jones, Rebecca C.; Steane, Dorothy A.; Vaillancourt, René E.; Potts, Brad M.; Joubert, Fourie; Barry, Kerrie; Pappas, Georgios J.; Strauss, Steven H.; Jaiswal, Pankaj; Grima-Pettenati, Jacqueline; Salse, Jérôme; Van de Peer, Yves; Rokhsar, Daniel S.; Schmutz, Jeremy (2014-06-11). "The genome of Eucalyptus grandis". Nature. 510 (7505). Springer Science and Business Media LLC: 356–362. Bibcode:2014Natur.510..356M. doi:10.1038/nature13308. hdl: 1854/LU-5655667 . ISSN   0028-0836. PMID   24919147. S2CID   4392576.
  29. 1 2 3 Werren, John H.; et al. (2010-01-15). "Functional and Evolutionary Insights from the Genomes of Three Parasitoid Nasonia Species". Science. 327 (5963). American Association for the Advancement of Science (AAAS): 343–348. Bibcode:2010Sci...327..343.. doi:10.1126/science.1178028. ISSN   0036-8075. PMC   2849982 . PMID   20075255.
  30. ↑ Olsen, Jeanine L.; Rouzé, Pierre; Verhelst, Bram; Lin, Yao-Cheng; Bayer, Till; Collen, Jonas; Dattolo, Emanuela; De Paoli, Emanuele; Dittami, Simon; Maumus, Florian; Michel, Gurvan; Kersting, Anna; Lauritano, Chiara; Lohaus, Rolf; Töpel, Mats; Tonon, Thierry; Vanneste, Kevin; Amirebrahimi, Mojgan; Brakel, Janina; Boström, Christoffer; Chovatia, Mansi; Grimwood, Jane; Jenkins, Jerry W.; Jueterbock, Alexander; Mraz, Amy; Stam, Wytze T.; Tice, Hope; Bornberg-Bauer, Erich; Green, Pamela J.; Pearson, Gareth A.; Procaccini, Gabriele; Duarte, Carlos M.; Schmutz, Jeremy; Reusch, Thorsten B. H.; Van de Peer, Yves (2016-01-27). "The genome of the seagrass Zostera marina reveals angiosperm adaptation to the sea". Nature. 530 (7590). Springer Science and Business Media LLC: 331–335. Bibcode:2016Natur.530..331O. doi:10.1038/nature16548. hdl: 10754/595150 . ISSN   0028-0836. PMID   26814964. S2CID   3713147.
  31. 1 2 Sadd, Ben M; et al. (2015-04-24). "The genomes of two key bumblebee species with primitive eusocial organization". Genome Biology. 16 (1). Springer Science and Business Media LLC: 76. doi: 10.1186/s13059-015-0623-3 . ISSN   1474-760X. PMC   4414376 . PMID   25908251.
  32. ↑ Suen, Garret; Teiling, Clotilde; Li, Lewyn; Holt, Carson; Abouheif, Ehab; Bornberg-Bauer, Erich; Bouffard, Pascal; Caldera, Eric J.; Cash, Elizabeth; Cavanaugh, Amy; Denas, Olgert; Elhaik, Eran; Favé, Marie-Julie; Gadau, Jürgen; Gibson, Joshua D.; Graur, Dan; Grubbs, Kirk J.; Hagen, Darren E.; Harkins, Timothy T.; Helmkampf, Martin; Hu, Hao; Johnson, Brian R.; Kim, Jay; Marsh, Sarah E.; Moeller, Joseph A.; Muñoz-Torres, Mónica C.; Murphy, Marguerite C.; Naughton, Meredith C.; Nigam, Surabhi; Overson, Rick; Rajakumar, Rajendhran; Reese, Justin T.; Scott, Jarrod J.; Smith, Chris R.; Tao, Shu; Tsutsui, Neil D.; Viljakainen, Lumi; Wissler, Lothar; Yandell, Mark D.; Zimmer, Fabian; Taylor, James; Slater, Steven C.; Clifton, Sandra W.; Warren, Wesley C.; Elsik, Christine G.; Smith, Christopher D.; Weinstock, George M.; Gerardo, Nicole M.; Currie, Cameron R. (2011-02-10). "The Genome Sequence of the Leaf-Cutter Ant Atta cephalotes Reveals Insights into Its Obligate Symbiotic Lifestyle". PLOS Genetics. 7 (2). Public Library of Science (PLoS): e1002007. doi: 10.1371/journal.pgen.1002007 . ISSN   1553-7404. PMC   3037820 . PMID   21347285.
  33. 1 2 Harrison, Mark C.; Jongepier, Evelien; Robertson, Hugh M.; Arning, Nicolas; Bitard-Feildel, Tristan; Chao, Hsu; Childers, Christopher P.; Dinh, Huyen; Doddapaneni, Harshavardhan; Dugan, Shannon; Gowin, Johannes; Greiner, Carolin; Han, Yi; Hu, Haofu; Hughes, Daniel S. T.; Huylmans, Ann-Kathrin; Kemena, Carsten; Kremer, Lukas P. M.; Lee, Sandra L.; Lopez-Ezquerra, Alberto; Mallet, Ludovic; Monroy-Kuhn, Jose M.; Moser, Annabell; Murali, Shwetha C.; Muzny, Donna M.; Otani, Saria; Piulachs, Maria-Dolors; Poelchau, Monica; Qu, Jiaxin; Schaub, Florentine; Wada-Katsumata, Ayako; Worley, Kim C.; Xie, Qiaolin; Ylla, Guillem; Poulsen, Michael; Gibbs, Richard A.; Schal, Coby; Richards, Stephen; Belles, Xavier; Korb, Judith; Bornberg-Bauer, Erich (2018-02-05). "Hemimetabolous genomes reveal molecular basis of termite eusociality". Nature Ecology & Evolution. 2 (3). Springer Science and Business Media LLC: 557–566. doi:10.1038/s41559-017-0459-1. ISSN   2397-334X. PMC   6482461 . PMID   29403074.
  34. ↑ van Loo, Bert; Heberlein, Magdalena; Mair, Philip; Zinchenko, Anastasia; Schüürmann, Jan; Eenink, Bernard D. G.; Holstein, Josephin M.; Dilkaute, Carina; Jose, Joachim; Hollfelder, Florian; Bornberg-Bauer, Erich (2019-12-20). "High-Throughput, Lysis-Free Screening for Sulfatase Activity Using Escherichia coli Autodisplay in Microdroplets" . ACS Synthetic Biology. 8 (12): 2690–2700. doi:10.1021/acssynbio.9b00274. PMID   31738524. S2CID   208169316.
  35. ↑ Lange, Andreas; Patel, Prajal H.; Heames, Brennen; Damry, Adam M.; Saenger, Thorsten; Jackson, Colin J.; Findlay, Geoffrey D.; Bornberg-Bauer, Erich (2021-03-12). "Structural and functional characterization of a putative de novo gene in Drosophila". Nature Communications. 12 (1): 1667. Bibcode:2021NatCo..12.1667L. doi:10.1038/s41467-021-21667-6. ISSN   2041-1723. PMC   7954818 . PMID   33712569.
  36. ↑ "HFSPO is pleased to announce the 2023 research grants and postdoctoral fellowships approved by the Board of Trustees in March 2023" . Retrieved 2023-04-06.
  37. ↑ "Priority Programme "Genomic Basis of Evolutionary Innovations (GEvol)" (SPP 2349)" . Retrieved 2022-03-04.
  38. ↑ "Neue Forschungsschwerpunkte in Münster" [New research priority programs in Münster.]. Westfalenspiegel (in German). 30 March 2021.
  39. ↑ "DFG SPP Genomic Basis of Evolutionary Innovations". 28 February 2022.
  40. ↑ "Bioinformatics and Biology Insights" . Retrieved 2022-06-30.
  41. ↑ "Journal of the Royal Society Interface" . Retrieved 2022-06-30.
  42. ↑ "BMC Evolutionary Biology" . Retrieved 2022-06-30.
  43. ↑ "Journal of Experimental Zoology" . Retrieved 2022-06-30.


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