Ferritin light chain

Last updated
FTL
Protein FTL PDB 2ffx.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases FTL , LFTD, NBIA3, ferritin, light polypeptide, ferritin light chain
External IDs OMIM: 134790 MGI: 5434102 HomoloGene: 79330 GeneCards: FTL
Orthologs
SpeciesHumanMouse
Entrez

2512

434624

Ensembl

ENSG00000087086

n/a

UniProt

P02792

n/a

RefSeq (mRNA)

NM_000146

n/a

RefSeq (protein)

NP_000137

n/a

Location (UCSC) Chr 19: 48.97 – 48.97 Mb n/a
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Ferritin light chain is a protein that in humans is encoded by the FTL gene. [4] [5] [6] Ferritin is the major protein responsible for storing intracellular iron in prokaryotes and eukaryotes. It is a heteropolymer consisting of 24 subunits, heavy and light ferritin chains. [6] This gene has multiple pseudogenes. [6]

Contents

It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these assisted reproductive technologies. [7]

Function

Iron is extremely important in the development of neurons, transport through iron-sulfur clusters, the electron transport chain, and synthesis and breakdown of neurotransmitters. The function of the FTL is to act as both an iron reservoir and to remove excess iron from the body. Since iron plays a role in electron transfer, there is potential for the generation of free, highly toxic radicals which makes the role of the FTL as an iron detoxifier very significant. [8] The rates of iron uptake and release may be affected by changes to the components of the ferritin light chains and heavy chains. [6] Although the ferritin light chain unlike the ferritin heavy chain has no ferroxidase activity, the light chain may be responsible for the electron transfer across the ferritin protein cage. [9]

Clinical significance

Oxidative stress caused by iron radicals generated in the ETC and an increase in iron levels caused by defects in the FTL gene has been known to be a cause of the onset of neurodegenerative diseases and hyperferritinemia-cataract syndrome. [8] [10]

Mutations of the FTL gene cause the rare adult-onset basal ganglia disease also known as neuroferritinopathy. [11] These mutations are specifically in exon four of the FTL gene. There are two distinct toxic mechanisms that lead to neuroferritinopathy and these are abnormalities in iron metabolism and the creation of free iron radicals, resulting in oxidative stress and cell death. [12]

Interactions

Ferritin light chain has been shown to interact with FTH1. [13] [14] An oxygen molecule acts as the terminal electron acceptor during the oxidation of iron in aerobic metabolism. A study conducted with different apoferritins with distinct compositions of heavy and light subunits revealed that both subunits have key roles in the electron transport chain. [9] Neither subunit on its own has the ability to reduce cytochrome c and thus the first step, the oxidation of Fe2+ to Fe3+, can be carried out by the heavy chain and the light chains are responsible for the transfer of electrons. [9]

FTL is regulated by iron and with an increase in iron, there is both an increase in the FTL expression and PEN-2 levels, which results in increased γ- secretase activity. In relation to this, the downregulation of FTL expression leads to a decrease in the protein levels of PEN-2. [15]

See also

Related Research Articles

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<span class="mw-page-title-main">SDHB</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">SDHA</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">HADHB</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Laminin subunit gamma-2</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Laminin subunit alpha-2</span> Protein-coding gene in the species Homo sapiens

Laminin subunit alpha-2 is a protein that in humans is encoded by the LAMA2 gene.

SCN2A Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Myosin-11</span> Protein-coding gene in the species Homo sapiens

Myosin-11 is a protein that in humans is encoded by the MYH11 gene.

<span class="mw-page-title-main">GNAT2</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">COX4I1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">NDUFS3</span> Protein-coding gene in the species Homo sapiens

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial is an enzyme that in humans is encoded by the NDUFS3 gene on chromosome 11. This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase. Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.

<span class="mw-page-title-main">NDUFA5</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">NDUFA8</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">NDUFA12</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">FTH1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Mitochondrial ferritin</span> Protein-coding gene in the species Homo sapiens

Mitochondrial ferritin is a ferroxidase enzyme that in humans is encoded by the FTMT gene.

<span class="mw-page-title-main">Neuroferritinopathy</span> Medical condition

Neuroferritinopathy is a genetic neurodegenerative disorder characterized by the accumulation of iron in the basal ganglia, cerebellum, and motor cortex of the human brain. Symptoms, which are extrapyramidal in nature, progress slowly and generally do not become apparent until adulthood. These symptoms include chorea, dystonia, and cognitive deficits which worsen with age.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000087086 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ Lebo RV, Kan YW, Cheung MC, Jain SK, Drysdale J (December 1985). "Human ferritin light chain gene sequences mapped to several sorted chromosomes". Hum. Genet. 71 (4): 325–8. doi:10.1007/BF00388458. PMID   3000916. S2CID   2574558.
  5. ↑ Gasparini P, Calvano S, Memeo E, Bisceglia L, Zelante L (Apr 1997). "Assignment of ferritin L gene (FTL) to human chromosome band 19q13.3 by in situ hybridization". Ann. Genet. 40 (4): 227–8. PMID   9526618.
  6. 1 2 3 4 "FTL ferritin, light polypeptide". National Center for Biotechnology Information. 5 July 2009. Retrieved 20 July 2009.
  7. ↑ Zhang Y, Zhang YL, Feng C, Wu YT, Liu AX, Sheng JZ, Cai J, Huang HF (October 2008). "Comparative proteomic analysis of human placenta derived from assisted reproductive technology". Proteomics. 8 (20): 4344–56. doi:10.1002/pmic.200800294. PMID   18792929. S2CID   206362532.
  8. 1 2 Vidal, Ruben; Miravalle, Leticia; Gao, Xiaoying; Barbeito, Ana G.; Baraibar, Martin A.; Hekmatyar, Shahryar K.; Widel, Mario; Bansal, Navin; Delisle, Marie B.; Ghetti, Bernardino (2008-01-02). "Expression of a Mutant Form of the Ferritin Light Chain Gene Induces Neurodegeneration and Iron Overload in Transgenic Mice". The Journal of Neuroscience. 28 (1): 60–67. doi:10.1523/JNEUROSCI.3962-07.2008. ISSN   0270-6474. PMC   2394191 . PMID   18171923.
  9. 1 2 3 Carmona U, Li L, Zhang L, Knez M (2014). "Ferritin light-chain subunits: key elements for the electron transfer across the protein cage". Chemical Communications. 50 (97): 15358–15361. doi:10.1039/c4cc07996e. PMID   25348725.
  10. ↑ Zandman-Goddard G, Shoenfeld Y (2007). "Ferritin in autoimmune diseases". Autoimmun Rev. 6 (7): 457–63. doi:10.1016/j.autrev.2007.01.016. PMID   17643933.
  11. ↑ Gregory A, Hayflick SJ (2011). "Genetics of neurodegeneration with brain iron accumulation". Curr Neurol Neurosci Rep. 11 (3): 254–61. doi:10.1007/s11910-011-0181-3. PMC   5908240 . PMID   21286947.
  12. ↑ Nishida, Katsuya; Garringer, Holly; Futamura, Naonobu; Funakawa, Itara; Jinnai, Kenji; Vidal, Ruben; Takao, Masaki (12 April 2014). "A novel ferritin light chain mutation in neuroferritinopathy with an atypical presentation". Journal of the Neurological Sciences. 342 (1–2): 173–177. doi:10.1016/j.jns.2014.03.060. PMC   4048789 . PMID   24825732 – via Hunter College Libraries.
  13. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
  14. ↑ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
  15. ↑ Li, Xinxin; Liu, Yiqian; Zheng, Qiuyang; Yao, Guorui; Cheng, Peng; Bu, Guojun; Xu, Huaxi; Zhang, Yun-Wu (8 May 2013). "Ferritin light chain interacts with PEN-2 and affects gamma- secretase activity". Neuroscience Letters. 548: 90–94. doi:10.1016/j.neulet.2013.05.018. PMC   3724929 . PMID   23685131.

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