| First Lady of Panama | |
|---|---|
 | |
| Residence | Palacio de las Garzas, Panama City |
| Inaugural holder | María de la Ossa de Amador |
| Formation | February 20, 1904 |
| Website | First Lady of the Republic of Panama |
First Lady and First Gentleman of Panama (Spanish : Primera Dama o Caballero de Panama) are unofficial titles traditionally held by the wife or husband of the president of Panama.
The following is an incomplete list of first ladies and gentlemen of Panama.
| No. | Portrait | Name | President | Birth | Death | Period |
| 1 |  | María de la Ossa de Amador | Manuel Amador Guerrero | March 1, 1855 | July 5, 1948 | February 20, 1904 – October 1, 1908 |
| 2 | Manuela Jované Aguilar y Távara (died) | José Domingo de Obaldía | 1887 | |||
| Josefa Jované Aguilar y Távara | José Domingo de Obaldía | 1 October 1908 – 1 March 1910 | ||||
| 3 | Rita Barsallo de Mendoza | Carlos Antonio Mendoza | 1 March 1910 – 1 October 1910 | |||
| 4 | Matilde Esperanza Picón Herrera | Pablo Arosemena | 5 October 1910 – 1 October 1912 | |||
| 5 | Eva Paniza Arosemena (separated) | Belisario Porras | ||||
| Alicia Castro Gutiérrez | Belisario Porras | |||||
| 6 |  | Diana Dutary Pérez | Ramón Maximiliano Valdés | 1 October 1916 – 3 June 1918 | ||
| Ofelina Remón de Chiari | Rodolfo Chiari | 1 October 1924 – 1 October 1928 | ||||
| Elizabeth "Fanny" Rojer de Lakas [1] | Demetrio B. Lakas | December 19, 1969 – October 11, 1978 | ||||
| Adela Ruiz de Royo | Aristides Royo | October 11, 1978 – July 31, 1982 | ||||
| Mercedes Martinez de la Espriella | Ricardo de la Espriella | July 31, 1982 – February 13, 1984 | ||||
| Mariela de Delvalle | Eric Arturo Delvalle | September 28, 1985 - February 26, 1988 | ||||
| Ana Mae Diaz [2] | Guillermo Endara | c. 1966 | June 10, 1990 – September 1, 1994 | |||
 | Dora Boyd de Perez Balladares [3] | Ernesto Pérez Balladares | September 1, 1994 – September 1, 1999 | |||
| Ruby Moscoso [4] | Mireya Moscoso | September 1, 1999 – September 1, 2004 | ||||
 | Vivian Fernández [5] | Martín Torrijos | March 25, 1966 | September 1, 2004 – July 1, 2009 | ||
 | Marta Linares [6] | Ricardo Martinelli | September 2, 1956 | July 1, 2009 - July 1, 2014 | ||
 | Lorena Castillo | Juan Carlos Varela | July 31, 1968 | July 1, 2014 - July 1, 2019 | ||
| Yazmín Colón de Cortizo | Laurentino Cortizo | July 1, 2019 - July 1, 2024 |
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