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IUPAC name (7R,10R,11R,12Z,17Z,19Z,21S,23R)-23-fluoro-21-hydroxy-11,19-dimethyl-10-propan-2-yl-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.03,7]octacosa-1(27),12,17,19,25(28)-pentaene-2,8,14-trione | |
Other names (16R)-16-Desoxy-16-fluoropristinamycin IIB; RPR 132552; RPR 132552A | |
Identifiers | |
3D model (JSmol) | |
ChemSpider | |
ECHA InfoCard | 100.218.104 |
EC Number |
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PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
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Properties | |
C28H38FN3O6 | |
Molar mass | 531.625 g·mol−1 |
Hazards | |
GHS labelling: | |
Warning | |
H302, H312, H317, H332, H341 | |
P201, P202, P261, P264, P270, P271, P272, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P321, P322, P330, P333+P313, P363, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Flopristin is a semi-synthetic antibiotic of the streptogramin A class. It is a fluorinated derivative of pristinamycin IIB.[ citation needed ]
Flopristin is one of the components of the experimental drug NXL103. [1]
The IBM 3270 is a family of block oriented display and printer computer terminals introduced by IBM in 1971 and normally used to communicate with IBM mainframes. The 3270 was the successor to the IBM 2260 display terminal. Due to the text color on the original models, these terminals are informally known as green screen terminals. Unlike a character-oriented terminal, the 3270 minimizes the number of I/O interrupts required by transferring large blocks of data known as data streams, and uses a high speed proprietary communications interface, using coaxial cable.
Systems Network Architecture (SNA) is IBM's proprietary networking architecture, created in 1974. It is a complete protocol stack for interconnecting computers and their resources. SNA describes formats and protocols but, in itself, is not a piece of software. The implementation of SNA takes the form of various communications packages, most notably Virtual Telecommunications Access Method (VTAM), the mainframe software package for SNA communications.
Clindamycin is an antibiotic medication used for the treatment of a number of bacterial infections, including osteomyelitis (bone) or joint infections, pelvic inflammatory disease, strep throat, pneumonia, acute otitis media, and endocarditis. It can also be used to treat acne, and some cases of methicillin-resistant Staphylococcus aureus (MRSA). In combination with quinine, it can be used to treat malaria. It is available by mouth, by injection into a vein, and as a cream or a gel to be applied to the skin or in the vagina.
Quinupristin/dalfopristin, or quinupristin-dalfopristin, is a combination of two antibiotics used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium.
Irma board, originally spelled IRMA board, refers to a brand of coaxial interface cards for PCs and Macintosh computers used to enable 3270 emulator programs to connect to IBM mainframe computers. IRMA boards were used to connect PCs and Macs to IBM 3274 terminal controllers.
Lincosamides are a class of antibiotics, which include lincomycin, clindamycin, and pirlimycin.
Pristinamycin (INN), also spelled pristinamycine, is an antibiotic used primarily in the treatment of staphylococcal infections, and to a lesser extent streptococcal infections. It is a streptogramin group antibiotic, similar to virginiamycin, derived from the bacterium Streptomyces pristinaespiralis. It is marketed in Europe by Sanofi-Aventis under the trade name Pyostacine.
The IBM 3270 PC, released in October 1983, is an IBM PC XT containing additional hardware that, in combination with software, can emulate the behaviour of an IBM 3270 terminal. It can therefore be used both as a standalone computer, and as a terminal to a mainframe.
Dalfopristin is a semi-synthetic streptogramin antibiotic analogue of ostreogyrcin A. The combination quinupristin/dalfopristin was brought to the market by Rhone-Poulenc Rorer Pharmaceuticals in 1999. Synercid is used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium.
Virginiamycin is a streptogramin antibiotic similar to pristinamycin and quinupristin/dalfopristin. It is a combination of pristinamycin IIA and virginiamycin S1. Virginiamycin is used in the fuel ethanol industry to prevent microbial contamination. It is also used in agriculture, specifically in livestock, to accelerate the growth of the animals and to prevent and treat infections. Antibiotics also save as much as 30% in feed costs among young swine, although the savings fade as pigs get older, according to a USDA study.
A protein synthesis inhibitor is a compound that stops or slows the growth or proliferation of cells by disrupting the processes that lead directly to the generation of new proteins.
The IBM Kanji System was announced in 1971 to support Japanese language processing on the IBM System/360 computers. It was later enhanced by the support of IBM System/34, IBM 5550 and DOS/V.
Streptogramin A is a group of antibiotics within the larger family of antibiotics known as streptogramins. They are synthesized by the bacteria Streptomyces virginiae. The streptogramin family of antibiotics consists of two distinct groups: group A antibiotics contain a 23-membered unsaturated ring with lactone and peptide bonds while group B antibiotics are depsipeptides. While structurally different, these two groups of antibiotics act synergistically, providing greater antibiotic activity than the combined activity of the separate components. These antibiotics have until recently been commercially manufactured as feed additives in agriculture, although today there is increased interest in their ability to combat antibiotic-resistant bacteria, particularly vancomycin-resistant bacteria.
Streptogramin B is a subgroup of the streptogramin antibiotics family. These natural products are cyclic hexa- or hepta depsipeptides produced by various members of the genus of bacteria Streptomyces. Many of the members of the streptogramins reported in the literature have the same structure and different names; for example, pristinamycin IA = vernamycin Bα = mikamycin B = osteogrycin B.
Linopristin/flopristin is an experimental drug candidate under development by Novexel. It is an oral streptogramin antibiotic that has potent in vitro activity against certain Gram-positive bacteria including methicillin resistant Staphylococcus aureus (MRSA), as well as the important respiratory pathogens including penicillin-, macrolide- and quinolone-resistant strains. It is a combination of linopristin and flopristin.
Aminocandin is an echinocandin antifungal. It works by targeting the glucan in fungal cell walls.
Linopristin is an antibiotic of the streptogramin B class. It is one of the components of the antibiotic combination NXL103.
Open Air St. Gallen is an annual music festival held near the city of St. Gallen, Switzerland. Founded in 1977, it is one of Switzerland's biggest and longest-running open air festivals. It is attended by more than 110,000 people each year.
NGC 3274 is a relatively faint spiral galaxy discovered by Wilhelm Herschel in 1783, and is located over 20 million light-years away in the constellation of Leo.
Gadolinium(III) hydroxide is a chemical compound with the formula Gd(OH)3. Its nanoparticles has a potential use for layering various drugs, such as diclofenac, ibuprofen, and naproxen.