GRWD1

GRWD1
Identifiers
Aliases	GRWD1 , CDW4, GRWD, RRB1, WDR28, glutamate-rich WD repeat containing 1, glutamate rich WD repeat containing 1
External IDs	OMIM: 610597 MGI: 2141989 HomoloGene: 6644 GeneCards: GRWD1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,457,022 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,480,368 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; stromal cell of endometrium; ; olfactory bulb; ; left uterine tube; ; body of stomach; ; right adrenal gland; ; skin of abdomen; ; left adrenal gland; ; pancreatic ductal cell; ; right coronary artery;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; yolk sac; ; condyle; ; primitive streak; ; fossa; ; somite; ; Paneth cell; ; morula; ; motor neuron;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	chromatin binding ; DNA replication origin binding ; RNA binding ; protein binding ; histone binding ;
Cellular component	nucleus ; nucleolus ; cytosol ; chromosome ; protein-containing complex ;
Biological process	nucleosome assembly ; nucleosome disassembly ; DNA replication ;
	Sources:Amigo / QuickGO
Orthologs
	83743
	101612
	ENSG00000105447
	ENSMUSG00000053801
	Q9BQ67
	Q810D6
	NM_031485
	NM_153419
	NP_113673
	NP_700468
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 08, 2023

Glutamate-rich WD repeat-containing protein 1 is a WD40 repeat protein that in humans is encoded by the GRWD1 gene. It localizes to the nucleus and has known functions in regulating chromatin openness and loading of MCM helicase.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105447 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053801 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gratenstein K, Heggestad AD, Fortun J, Notterpek L, Pestov DG, Fletcher BS (Jun 2005). "The WD-repeat protein GRWD1: potential roles in myeloid differentiation and ribosome biogenesis". Genomics. 85 (6): 762–73. doi:10.1016/j.ygeno.2005.02.010. PMID 15885502.
↑ "Entrez Gene: GRWD1 glutamate-rich WD repeat containing 1".

Nagase T, Kikuno R, Ohara O (Dec 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (Nov 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617 . PMID 12429849.
Trzcińska AM, Girstun A, Piekiełko A, Kowalska-Loth B, Staroń K (Dec 2002). "Potential protein partners for the N-terminal domain of human topoisomerase I revealed by phage display". Molecular Biology Reports. 29 (4): 347–52. doi:10.1023/A:1021237021338. PMID 12549820. S2CID 9602116.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H (Nov 2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation". Nature Cell Biology. 8 (11): 1277–83. doi:10.1038/ncb1490. hdl: 10397/34293 . PMID 17041588. S2CID 22180568.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105447 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053801 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15885502-5] Gratenstein K, Heggestad AD, Fortun J, Notterpek L, Pestov DG, Fletcher BS (Jun 2005). "The WD-repeat protein GRWD1: potential roles in myeloid differentiation and ribosome biogenesis". Genomics. 85 (6): 762–73. doi:10.1016/j.ygeno.2005.02.010. PMID 15885502.

[entrez-6] "Entrez Gene: GRWD1 glutamate-rich WD repeat containing 1".

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GRWD1

Related Research Articles

References

Further reading