Gefarnate

Last updated
Gefarnate
Gefarnate.svg
Gefarnate-3D-spacefill.png
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
Identifiers
  • (2E)-3,7-dimethylocta-2,6-dien-1-yl (4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.000.111 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C27H44O2
Molar mass 400.647 g·mol−1
3D model (JSmol)
  • CC(C)=CCC/C(C)=C/CC/C(C)=C/CCC(=O)OC/C=C(C)/CCC=C(C)C
  • InChI=1S/C27H44O2/c1-22(2)12-8-14-24(5)16-10-17-25(6)18-11-19-27(28)29-21-20-26(7)15-9-13-23(3)4/h12-13,16,18,20H,8-11,14-15,17,19,21H2,1-7H3/b24-16+,25-18+,26-20+ X mark.svgN
  • Key:ZPACYDRSPFRDHO-ROBAGEODSA-N X mark.svgN
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Gefarnate is a drug used for the treatment of gastric ulcers. [1]

It also has been proposed for use in the treatment of dry eye syndrome. [2] [3]

References

  1. Ohta Y, Kobayashi T, Imai Y, Inui K, Yoshino J, Nakazawa S (August 2005). "Effect of gefarnate on acute gastric mucosal lesion progression in rats treated with compound 48/80, a mast cell degranulator, in comparison with that of teprenone" . Biol. Pharm. Bull. 28 (8): 1424–30. doi: 10.1248/bpb.28.1424 . PMID   16079487.
  2. Peral A, Domínguez-Godínez CO, Carracedo G, Pintor J (April 2008). "Therapeutic targets in dry eye syndrome". Drug News Perspect. 21 (3): 166–76. doi:10.1358/dnp.2008.21.3.1203413. PMID   18560615.
  3. Gipson IK, Hori Y, Argüeso P (April 2004). "Character of ocular surface mucins and their alteration in dry eye disease" . Ocul Surf. 2 (2): 131–48. doi:10.1016/s1542-0124(12)70149-0. PMID   17216084.[ permanent dead link ]