Gene Block | |
---|---|
6th Chancellor of the University of California, Los Angeles | |
In office August 1, 2007 –July 31, 2024 | |
Preceded by | Albert Carnesale Norman Abrams (acting) |
Succeeded by | Darnell Hunt (interim) |
Personal details | |
Born | Monticello,New York,U.S. | August 17,1948
Education | Stanford University (BA) University of Oregon (MS,PhD) |
Scientific career | |
Fields | Neurobiology |
Institutions | |
Thesis | Efferent control of the circadian oscillator in the eye of Aplysia (1975) |
Doctoral advisor | Marvin Gordon-Lickey |
Other academic advisors | Donald Kennedy Colin Pittendrigh |
Doctoral students | Douglas G. McMahon |
Other notable students | Andrew Millar Nancy L. Wayne |
Gene David Block (born August 17, 1948) [1] is an American biologist and former academic administrator. He served as the 6th chancellor of the University of California, Los Angeles from 2007 to 2024. Previously at the University of Virginia, Block served as executive vice president and provost from 2001 to 2007, vice president for research and public service from 1998 to 2001, and vice provost for research from 1993 to 1998.
Block was born in Monticello, New York, the grandson of Jewish immigrants from Eastern Europe. [2] His father and uncle owned Mountain Dairies, a retail/wholesale distributor that served many of the hotels and camps that populated Catskill region of New York. During summers, he worked at the dairy as a truck driver. He played varsity tennis at Monticello High School.
Block received a Bachelor of Arts with a major in psychology from Stanford University in 1970. He received a Master of Science in 1972 and a Doctor of Philosophy in 1975 in psychology from the University of Oregon. [3] [4]
From 1975 to 1978, he returned to Stanford for postdoctoral work with Donald Kennedy (who later became the 8th president of Stanford) and Colin Pittendrigh (who is known as the “father of biological timing"). During his postdoctoral research years, Block studied how voluntary movements inhibit sensory feedback in the crayfish working in the Kennedy lab while studying issues of circadian biology with Colin Pittendrigh.
In 1978, Block became a member of the faculty in the Department of Biology of University of Virginia. Here, Block served as the vice provost for research from 1993 to 1998, vice president for research and public service from 1998 to 2001, and then in 2001 he was appointed as executive vice president and provost. Furthermore, during this time from 1991 to 2002, Block also served as the founding director of the National Science Foundation Science and Technology Center in Biological Timing. [5]
According to Block, “The center raised the national visibility of the University in biological and medical research, and gave us reputational leverage in the U.S. as well as in Europe and Japan... Most importantly, the center’s scientific accomplishments have been spectacular. We’ve done some high-risk research that has paid off greatly; some of it has fundamentally changed our understanding of biological processes.” [6]
One of the center's biggest advances, largely by Joseph Takahashi, was the development of a mutant mouse that allowed for the identification and cloning of the “Clock” gene for the biological clock in a mouse in 1997. This was the first such gene to be identified at the molecular level in a mammal. This groundbreaking discovery was a result of the Clock Genome Project, which uses "forward genetics" to discover the genes regulating circadian clocks in mice, fruit flies, and plants. In addition, this work also led to the discovery of many other genes that regulate the biological clock. [7]
In 1997 and 1998, the reputable journal Science ranked the findings of the NSF Center in Biological Timings among the top 10 in biological research breakthroughs. [7]
Three of the NSF Center investigators, Jeffrey C. Hall, Michael Rosbash and Michael W. Young,[ clarification needed ] received the 2017 Nobel Prize in Physiology or Medicine “for their discoveries of molecular mechanisms controlling the circadian rhythm.” [8]
Block was appointed Chancellor of UCLA in 2007. His selection was announced on 21 December 2006, succeeding interim office holder Norman Abrams on 1 August 2007. [9]
On February 24, 2014, Block published an open letter to the campus community, expressing his opposition to Proposition 209, stating that the proposed merit-based selection system would damage diversity on campus. [10]
He has been widely criticized for the 2022 suspension of highly-awarded professor of ecology Priyanga Amarasekare without documentation, viewed as retaliation for her calls for reform of a culture of discrimination at UCLA. [11]
In his inaugural address at UCLA, Block shared that his top priorities are to advance academic excellence, financial stability, diversity and civic engagement. [12] He has called for UCLA to deepen its engagement with Los Angeles and to increase access for students from underrepresented populations. [13] Under Block's leadership, UCLA has seen an increase in student diversity on campus thanks to innovative efforts to recruit in diverse communities, and in 2015, UCLA reached pre-California Proposition 209 levels, enrolling 279 African American freshmen, on par with the African American share of California public high school graduates. [14] UCLA has also increased the number of low- to middle-income students enrolled. [15]
In 2019 UCLA was named the number one public university in the nation for the third consecutive year [16] and is consistently the most applied-to university, with more than 113,000 freshman applications for fall 2018. [17]
Block's push for entrepreneurship on campus has fostered innovation and resulted in UCLA as the top university for creating startups based on campus research. [18] Additionally, to foster a deeper commitment to Los Angeles among UCLA students, Block oversaw the formation of the annual Volunteer Day event, in which thousands of students volunteer in schools, parks, food banks, veterans’ clinics and elsewhere at the beginning of each academic year. [19] Block also implemented UCLA's two Grand Challenges, which are aimed at understanding, treating and preventing depression worldwide, [20] and moving Los Angeles toward 100 percent renewable energy, 100 percent locally sourced water and enhanced ecosystem health by 2050. [21]
During his tenure, Block has faced the challenge of steering UCLA through a severe budget crisis and tuition increases. [22] To address reductions in state funding and advance his priorities, Block is leading the largest fundraising campaign by a public university, aiming to raise $4.2 billion to support student scholarships and fellowships, research projects and new construction on campus in honor of UCLA's centennial in 2019. [23]
Block holds UCLA faculty appointments in psychiatry and bio-behavioral sciences in the David Geffen School of Medicine and in integrative biology and physiology in the College of Letters and Science. [24]
On April 25, 2024, a pro-Palestinian occupation protest began at UCLA to protest the administration's investments in Israel amid the Israel–Hamas war. [25] On May 1, violent clashes were reported on the UCLA campus in which groups of counter-demonstrators supporting Israel attacked pro-Palestinian protesters. The clashes began shortly after Block declared that the pro-Palestinian encampment was "unlawful" and students who remained would face disciplinary action. [26] In the days after the incident, senate faculty members from the departments of History, [27] English, Comparative Literature, and Writing Programs, [28] Asian American Studies, [29] World Arts and Cultures/Dance, [30] Disability Studies, [31] Gender Studies, [32] Information Studies, [33] Chicano/a and Central American Studies, [34] Art, [35] Art History, [36] Philosophy, [37] African American Studies, [38] Sociology, [39] Anthropology, [40] and Society & Genetics, [41] the Center for the Study of Women, [42] in addition to subsets of faculty from the departments of Epidemiology, [43] Social Welfare, [44] Education, [45] Mathematics, [46] Design Media Arts, [47] the Luskin School of Public Affairs [48] (and its graduate students), [49] the David Geffen School of Medicine, [50] and the School of Theater, Film, and Television, [51] faculty and staff from the broader UC system, [52] alumni groups, [53] the representatives of the Undergraduate Students Association (student government), [54] and a joint statement by the California Federation of Teachers and the University Council-AFT [55] (which respectively represent educators and classified professionals, and UC librarians and non-Senate faculty), along with an individual statement from UC-AFT Local 1474, [56] issued calls for votes of no confidence and/or the immediate resignation of Block due to his handling of the conflict. A supermajority of voting UC-AFT Local 1474 members voted to express no confidence in Block's leadership. [57] Ultimately, opponents of Block failed to force him to resign, as neither censure nor a vote of no confidence passed in the UCLA Academic Senate on May 16, 2024. [58] [59]
On August 3, 2023, Block announced his impending retirement nearly a year in advance. [60] He officially stepped down on July 31, 2024, ending his seventeen-year tenure as chancellor.
While at the University of Virginia, Block worked extensively with his graduate student, Douglas G. McMahon, the 1986 winner of the Society for Neuroscience's Donald B. Lindsley Prize in Behavioral Neuroscience, on the functioning of the circadian pacemaker system at the cellular level in Bulla gouldiana. In 1984, Block's students conducted a continuous 74-hour intracellular recording in constant darkness that demonstrated that basal retinal neurons (BRN) in the Bulla eye exhibit clear circadian rhythms. These rhythms were also shown to be correlated one-for-one with compound action potentials produced by the optic nerve. [61] The change in membrane potential of the BRNs, which are electrically coupled, were shown to precede or occur simultaneously with the increased compound action potential frequency. An increase in firing frequency, and depolarization of the BRNs, was seen during the day, and the reverse at night. These results demonstrated that the BRNs were at minimum an output for the pacemaker pathway and provided evidence that they were good candidates for being circadian pacemaker neurons.
This research was expanded several years later by a breakthrough study published in [[Science (journal)|] in which Stephan Michel and others working in Block's laboratory demonstrated that circadian rhythms in BRN membrane conductance could persist spontaneously in isolated BRNs. [62] These spontaneous circadian rhythms were shown for BRNs in isolation from other retinal cells and in isolation from each other. They showed that these circadian rhythms in membrane conductance were caused primarily by a potassium ion current. BRNs in isolation demonstrated the same patterns shown in Block's previous work in which membrane conductance decreased at dawn and increased at dusk. That similar patterns were seen in isolated cells as in previous multiple cell cultures provided the first strong evidence that individual neurons possessed the capacity to generate circadian rhythms. This research definitively concluded that BRNs are both necessary and sufficient for photoentrainment in Bulla.
Block and colleagues hypothesized that ion movement across cell membranes plays a role in the generation of circadian rhythms. In 2005, his lab measured rhythms in rat suprachiasmatic nuclei (SCN) in various concentrations of calcium ions. Block found that as calcium concentration decreased, thus lowering the transmembrane ion movement, the amplitude of circadian rhythmicity also decreased. [63] With no calcium added, there was no circadian rhythm at all. Block's lab repeated the experiment with rat liver tissue and mouse SCN tissue and found the same results in each case. This demonstrated that across species and tissues, transmembrane calcium flux is necessary for the generation of circadian rhythms. However, there are still some questions about the function of calcium flux. In this experiment, Block also tried adding calcium channel Blockers to the tissues. Rhythmicity did disappear, but it took several cycles, and it is unknown why rhythmicity was not immediately abolished. In addition, Block suspects that calcium flux plays a role in the entrainment of the mammalian clock to the environment, similar to its role in mollusk entrainment.
Block has also studied the effect that aging has on the circadian system, collaborating with other leading chronobiologists including Michael Menaker. In 2002, he studied rhythmicity in rats of various ages and found that aging affected rhythmicity differently in different tissues. In the SCN, the intrinsic period shortened with age, while lung tissue often became arrhythmic (showing sporadic activity) and pineal and kidney tissues became phase advanced. [64] In 2008, Block exposed rats of various ages to different light cycles, and found that phase advances took longer in the SCN in old rats than in young rats, but pineal tissues advanced faster in older rats. Liver tissues did not phase shift at all when the light cycle was advanced. [65] These studies together have shown how complex the aging process is in the circadian system. Block notes that some, though not all, of these changes are likely influenced by diminishing synchronizing signals from the SCN. In 2006, Block observed that jetlag significantly increased the death rate in older mice, which highlights the medical importance of understanding the aging process of the circadian system. [66]
In 1970, Block married Carol Kullback, also from Monticello; they have two grown children. [69]
A circadian rhythm, or circadian cycle, is a natural oscillation that repeats roughly every 24 hours. Circadian rhythms can refer to any process that originates within an organism and responds to the environment. Circadian rhythms are regulated by a circadian clock whose primary function is to rhythmically co-ordinate biological processes so they occur at the correct time to maximize the fitness of an individual. Circadian rhythms have been widely observed in animals, plants, fungi and cyanobacteria and there is evidence that they evolved independently in each of these kingdoms of life.
Chronobiology is a field of biology that examines timing processes, including periodic (cyclic) phenomena in living organisms, such as their adaptation to solar- and lunar-related rhythms. These cycles are known as biological rhythms. Chronobiology comes from the ancient Greek χρόνος, and biology, which pertains to the study, or science, of life. The related terms chronomics and chronome have been used in some cases to describe either the molecular mechanisms involved in chronobiological phenomena or the more quantitative aspects of chronobiology, particularly where comparison of cycles between organisms is required.
The University of California, Los Angeles (UCLA) traces back to the 19th century when the institution operated as a teachers' college. It grew in size and scope for nearly four decades on two Los Angeles campuses before California governor William D. Stephens signed a bill into law in 1919 to establish the Southern Branch of the University of California. As the university broke ground for its new Westwood campus in 1927 and dissatisfaction grew for the "Southern Branch" name, the UC Regents formally adopted the "University of California at Los Angeles" name and "U.C.L.A." abbreviation that year. The "at" was removed in 1958 and "UCLA" without periods became the preferred stylization under Chancellor Franklin D. Murphy in the 1960s. In the first century after its founding, UCLA established itself as a leading research university with global impact across arts and culture, education, health care, technology and more.
The UCLA College of Letters and Science is the arts and sciences college of the University of California, Los Angeles (UCLA). It encompasses the Life and Physical Sciences, Humanities, Social Sciences, Honors Program and other programs for both undergraduate and graduate students. It is often called UCLA College or the College, which is not ambiguous because the College is the only educational unit at UCLA to be currently denominated as a "college." All other educational units at UCLA are currently labeled as schools or institutes.
Pradeep Kumar Khosla is an Indian-American computer scientist and university administrator. He is the current chancellor of the University of California, San Diego since August 1, 2012.
Hargurdeep Saini is an Indian-Canadian scientist and university administrator. He is the President and Vice-Chancellor of McGill University in Montreal. He was previously the President and Vice-Chancellor of Dalhousie University, a Vice-Chancellor and President of University of Canberra, a vice-president of University of Toronto, and principal of the university's Mississauga campus.
Fred W. Turek is the Director of the Center for Sleep & Circadian Biology and the Charles E. & Emma H. Morrison Professor of Biology in the Department of Neurobiology, both at Northwestern University. Turek received his Ph.D from Stanford University. He was awarded a Guggenheim Fellowship in 1991.
Michael Morris Rosbash is an American geneticist and chronobiologist. Rosbash is a professor and researcher at Brandeis University and investigator at the Howard Hughes Medical Institute. Rosbash's research group cloned the Drosophila period gene in 1984 and proposed the Transcription Translation Negative Feedback Loop for circadian clocks in 1990. In 1998, they discovered the cycle gene, clock gene, and cryptochrome photoreceptor in Drosophila through the use of forward genetics, by first identifying the phenotype of a mutant and then determining the genetics behind the mutation. Rosbash was elected to the National Academy of Sciences in 2003. Along with Michael W. Young and Jeffrey C. Hall, he was awarded the 2017 Nobel Prize in Physiology or Medicine "for their discoveries of molecular mechanisms controlling the circadian rhythm".
Michael Menaker, was an American chronobiologist who was Commonwealth Professor of Biology at University of Virginia. His research focused on circadian rhythmicity of vertebrates, including contributing to an understanding of light input pathways on extra-retinal photoreceptors of non-mammalian vertebrates, discovering a mammalian mutation for circadian rhythmicity, and locating a circadian oscillator in the pineal gland of bird. He wrote almost 200 scientific publications.
Jeffrey Connor Hall is an American geneticist and chronobiologist. Hall is Professor Emeritus of Biology at Brandeis University and currently resides in Cambridge, Maine.
Jennifer L. Mnookin is an American legal scholar and academic serving as chancellor of the University of Wisconsin–Madison since 2022. She previously served as dean of the UCLA School of Law, where she was David G. Price and Dallas P. Price Professor of Law. While at UCLA Law, she co-founded and co-directed the Program on Understanding Law, Science and Evidence.
Douglas G. McMahon is a professor of Biological Sciences and Pharmacology at Vanderbilt University. McMahon has contributed several important discoveries to the field of chronobiology and vision. His research focuses on connecting the anatomical location in the brain to specific behaviors. As a graduate student under Gene Block, McMahon identified that the basal retinal neurons (BRNs) of the molluscan eye exhibited circadian rhythms in spike frequency and membrane potential, indicating they are the clock neurons. He became the 1986 winner of the Society for Neuroscience's Donald B. Lindsley Prize in Behavioral Neuroscience for his work. Later, he moved on to investigate visual, circadian, and serotonergic mechanisms of neuroplasticity. In addition, he helped find that constant light can desynchronize the circadian cells in the suprachiasmatic nucleus (SCN). He has always been interested in the underlying causes of behavior and examining the long term changes in behavior and physiology in the neurological modular system. McMahon helped identifying a retrograde neurotransmission system in the retina involving the melanopsin containing ganglion cells and the retinal dopaminergic amacrine neurons.
Amita Sehgal is a molecular biologist and chronobiologist in the Department of Neuroscience at the Perelman School of Medicine at the University of Pennsylvania. Sehgal was involved in the discovery of Drosophila TIM and many other important components of the Drosophila clock mechanism. Sehgal also played a pivotal role in the development of Drosophila as a model for the study of sleep. Her research continues to be focused on understanding the genetic basis of sleep and also how circadian systems relate to other aspects of physiology.
Steve A. Kay is a British-born chronobiologist who mainly works in the United States. Dr. Kay has pioneered methods to monitor daily gene expression in real time and characterized circadian gene expression in plants, flies and mammals. In 2014, Steve Kay celebrated 25 years of successful chronobiology research at the Kaylab 25 Symposium, joined by over one hundred researchers with whom he had collaborated with or mentored. Dr. Kay, a member of the National Academy of Sciences, U.S.A., briefly served as president of The Scripps Research Institute. and is currently a professor at the University of Southern California. He also served on the Life Sciences jury for the Infosys Prize in 2011.
Carl Hirschie Johnson is an American-born biologist who researches the chronobiology of different organisms, most notably the bacterial circadian rhythms of cyanobacteria. Johnson completed his undergraduate degree in Honors Liberal Arts at the University of Texas at Austin, and later earned his PhD in biology from Stanford University, where he began his research under the mentorship of Dr. Colin Pittendrigh. Currently, Johnson is the Stevenson Professor of Biological Sciences at Vanderbilt University.
Andrew John McWalter Millar is a Scottish chronobiologist, systems biologist, and molecular geneticist. Millar is a professor at The University of Edinburgh and also serves as its chair of systems biology. Millar is best known for his contributions to plant circadian biology; in the Steve Kay lab, he pioneered the use of luciferase imaging to identify circadian mutants in Arabidopsis. Additionally, Millar's group has implicated the ELF4 gene in circadian control of flowering time in Arabidopsis. Millar was elected to the Royal Society in 2012 and the Royal Society of Edinburgh in 2013.
Carla Beth Green is an American neurobiologist and chronobiologist. She is a professor in the Department of Neuroscience and a Distinguished Scholar in Neuroscience at the University of Texas Southwestern Medical Center. She is the former president of the Society for Research on Biological Rhythms (SRBR), as well as a satellite member of the International Institute for Integrative Sleep Medicine at the University of Tsukuba in Japan.
Elaine Munsey Tobin is a professor of molecular, cell, and developmental biology at the University of California, Los Angeles (UCLA). Tobin is recognized as a Pioneer Member of the American Society of Plant Biologists (ASPB).
On April 25, 2024, a student protest began at the University of California, Los Angeles (UCLA) to protest the administration's investments in Israel. The occupation, self-titled as the 'Palestine Solidarity Encampment', was a part of pro-Palestine protests on university campuses campaigning for divestment from Israel. The encampment was attacked multiple times by counter protestors, leading to clashes. On May 2, the Los Angeles Police Department (LAPD) raided and dismantled the encampment, arresting the protestors and ending the occupation.
UAW Local 4811 is the chapter of United Auto Workers labor union representing academic student employees, graduate student researchers, academic researchers as well as postdoctoral researchers from all the 11 campuses of the University of California system. UAW Local 4811 was formed by merging UAW Local 2865 and UAW Local 5810 into one combined union in March 2024.
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