Gentisate 1,2-dioxygenase

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gentisate 1,2-dioxygenase
Identifiers
EC no. 1.13.11.4
CAS no. 9029-48-5
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BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
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In enzymology, a gentisate 1,2-dioxygenase (EC 1.13.11.4) is an enzyme that catalyzes the chemical reaction

2,5-dihydroxybenzoate + O2 maleylpyruvate

Thus, the two substrates of this enzyme are 2,5-dihydroxybenzoate and O2, whereas its product is 3-maleylpyruvate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is gentisate:oxygen 1,2-oxidoreductase (decyclizing). Other names in common use include gentisate oxygenase, 2,5-dihydroxybenzoate dioxygenase, gentisate dioxygenase, and gentisic acid oxidase. This enzyme participates in tyrosine metabolism. It employs one cofactor, iron.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2D40.

Related Research Articles

An oxygenase is any enzyme that oxidizes a substrate by transferring the oxygen from molecular oxygen O2 (as in air) to it. The oxygenases form a class of oxidoreductases; their EC number is EC 1.13 or EC 1.14.

<span class="mw-page-title-main">Catechol 1,2-dioxygenase</span>

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<span class="mw-page-title-main">Gentisic acid</span> Chemical compound

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In enzymology, a 2,3-dihydroxybenzoate 2,3-dioxygenase (EC 1.13.11.28) is an enzyme that catalyzes the chemical reaction

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<span class="mw-page-title-main">HAAO</span> Enzyme

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<span class="mw-page-title-main">Biphenyl-2,3-diol 1,2-dioxygenase</span>

Biphenyl-2,3-diol 1,2-dioxygenase (EC 1.13.11.39) is an enzyme that catalyzes the chemical reaction

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In enzymology, a linoleate diol synthase (EC 1.13.11.44) is an enzyme that catalyzes the chemical reaction

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<span class="mw-page-title-main">Protocatechuate 3,4-dioxygenase</span>

In enzymology, a protocatechuate 3,4-dioxygenase (EC 1.13.11.3) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">3-Maleylpyruvic acid</span> Chemical compound

3-Maleylpyruvic acid, or 3-maleylpyruvate, is a dicarboxylic acid formed by the oxidative ring opening of gentisic acid by gentisate 1,2-dioxygenase during the metabolism of tyrosine. It is converted into 3-fumarylpyruvate by maleylpyruvate isomerase.

References