Ghanshyam Swarup | |
|---|---|
| Born | 23 November 1953 Uttar Pradesh, India |
| Nationality | Indian |
| Alma mater | |
| Known for | Discovery of a nuclear protein tyrosine phosphatase Studies on Glaucoma |
| Awards | 1989 CSIR Young Scientist Award 1996 Shanti Swarup Bhatnagar Prize |
| Scientific career | |
| Fields | |
| Institutions | |
Ghanshyam Swarup (born 1953) is an Indian molecular biologist, a J. C. Bose National Fellow and the head of the Ghanshyam Swarup Research Group of the Centre for Cellular and Molecular Biology. [1] He is known for his studies on glaucoma and the discovery of protein tyrosine phosphatase, a new protein influencing the regulation of cell proliferation. [2] Swarup is an elected fellow of the Indian Academy of Sciences, [3] the Indian National Science Academy [4] and the National Academy of Sciences, India. [5] The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 1996, for his contributions to biological sciences. [6]
Ghanshyam Swarup, born on 23 November 1953 in the Indian state of Uttar Pradesh, graduated in science from Chhatrapati Shahu Ji Maharaj University and continued his studies there to secure a master's degree before moving to Mumbai to complete his PhD at Tata Institute of Fundamental Research (TIFR). [4] His post-doctoral studies were at David L. Garbers' laboratory of Vanderbilt University School of Medicine where he had the opportunity to work alongside Stanley Cohen, the 1986 Nobel laureate. Returning to India, Swarup joined the Centre for Cellular and Molecular Biology as a scientist [7] and is the head of Ghanshyam Swarup Group which carries out researches on optineurin and the functional defects caused in humans by its mutations. [8]
Swarup, while working with Stanley Cohen in the US on cellular signaling mechanisms, is reported to have discovered a new nuclear protein tyrosine phosphatase (PTPase) and his subsequent work demonstrated that the protein plays a part in the regulation of cell proliferation. [9] Later, during his early days at CCMB, he elucidated the molecular cloning of a protein tyrosine phosphatase and its bind with DNA and established the methodology for alternative splicing of a gene to form four different variations of PTPase. [4] Swarup's studies are known to have assisted in identifying the first cargo (PTP-S4/TC48) for the putative cargo receptors in mammalian cells. He has established a laboratory, Ghanshyam Swarup Group, where his team focuses on researches on protein optineurin and how disease-associated mutation affect humans. [8] Associated with L. V. Prasad Eye Institute, he works on one of the mutated genes of optineurin as a causative factor of glaucoma, an eye disease leading to irrecoverable loss of vision [10] and has elaborated on the pathogenesis in the disease from a molecular perspective. [11]
Swarup has published several articles detailing his research findings; [note 1] ResearchGate, an online repository of scientific articles has listed 81 of them. [12] He is a member of the editorial board of the Journal of Molecular Signaling [13] and is known to be active in the researches done by others. [14] Swarup has mentored several scholars in their doctoral and post-doctoral researches at his research group in CCMB [1] as well as scholars from other institutions. [15]
Swarup, who was elected as a fellow by the National Academy of Sciences, India in 1988, [5] received the Young Scientist Award of the Council of Scientific and Industrial Research in 1989. [4] The Indian Academy of Sciences made him their elected fellow in 1995 [3] and the CSIR honored him again in 1996 with the Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards. [6] An elected member of the Guha Research Conference, Swarup became an elected fellow of the Indian National Science Academy in 2003. [4] In 2011, he was selected for the J. C. Bose National Fellowship of the Department of Science and Technology [16] on which he pursues his current researches at CCMB. [1]
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Tata Institute of Fundamental Research (TIFR) is an Indian Research Institute under the Department of Atomic Energy of the Government of India. It is a public deemed university located at Navy Nagar, Colaba in Mumbai. It also has campus in Bangalore, International Centre for Theoretical Sciences (ICTS), and an affiliated campus in Serilingampally near Hyderabad. TIFR conducts research primarily in the natural sciences, the biological sciences and theoretical computer science.
The Centre for Cellular and Molecular Biology or CCMB is an Indian fundamental life science research establishment located in Hyderabad that operates under the aegis of the Council of Scientific and Industrial Research. CCMB is a designated "Centre of Excellence" by the Global Molecular and Cell Biology Network, UNESCO.
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Dr.Krishnarajanagar Nagappa Ganesh is an Indian Bio-Organic chemist and served as the (founding) director of Indian Institute of Science Education and Research, Tirupati since 2017 till 2023. He is also the founding Director of Indian Institute of Science Education and Research, Pune, that was established in 2006 and served the office till 2017. He is a recipient of the Shanti Swarup Bhatnagar Prize in chemical sciences (1998) for "his outstanding contribution towards the understanding of the chemical principles of DNA molecular recognition and for his work on various facets of DNA structure and its interaction with drugs and proteins". He is also a Fellow of the Indian National Science Academy since 2000.
