Gopal Kundu

Last updated

Gopal Kundu
Born (1959-11-02) 2 November 1959 (age 64)
Bataspur, West Bengal
Nationality Indian
Known for Therapeutics; Biomarker (cell); Angiogenesis; Nanomedicine;
Awards N-BIOS Prize, Shanti Swarup Bhatnagar Prize for Science and Technology
Scientific career
Fields Cancer
Institutions National Centre for Cell Science

Gopal Chandra Kundu (born 1959) is an Indian cell and cancer biologist and a Senior Scientist (Scientist-G) at National Centre for Cell Science. [1] He is known for his contributions towards the understanding the mechanism of cancer progression in breast, melanoma and other cancers and development of novel therapeutic targets and target-based therapy in cancers. [2]

Contents

An elected fellow of the Indian Academy of Sciences [3] and the National Academy of Sciences, India, [4] he received the National Bioscience Award for Career Development of the Department of Biotechnology in 2003. [5] The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2004, for his contributions to biological sciences. [6]

Education and career

Kundu obtained his Ph.D. from Bose Institute, Kolkata, India (1989) in protein biochemistry and did his post-doctoral research work at the Cleveland Clinic Foundation, University of Colorado, University of Wyoming, and the National Institutes of Health from 1989 to 1998. He has performed work in the area of cardiovascular biology, inflammation and immunomodulation during that period. In 1998, he joined as Scientist-D at the National Centre for Cell Science (NCCS), Pune. [7] At present, he is working as Scientist-G at NCCS. His area of research at NCCS is tumor biology, regulation of gene expression, cell signaling, angiogenesis, cancer therapeutics, biomarker studies for cancer detection, and nanomedicine. [8] [9]

He is Fellow of The National Academy of Sciences, India, and Indian Academy of Sciences. He is member of American Society for Biochemistry and Molecular Biology and New York Academy of Sciences.[ citation needed ] He has published 70 papers in peer reviewed international journals.[ citation needed ]

He serves as Editorial Board Member of Current Molecular Medicine , Molecular Medicine Reports, The Open Cancer Journal and American Journal of Cancer Research .[ citation needed ]

Awards

In 2004 Kundu was awarded a Shanti Swarup Bhatnagar Prize for Science and Technology, [10] [11] following the receipt of an earlier National Bioscience Award for Career Development in 2003. [11] International Journal of Oncology, Oncology Reports and International Journal of Molecular Medicine Award for an outstanding achievement in Oncology, Greece; International Young Investigator Award, USA. 7th National Grassroots Innovation Award-2013, Rashtrapati Bhavan, New Delhi.

Controversy

A controversy erupted in the NCCS in 2006 when an anonymous mail alleged that Kundu and others might have misrepresented data in a paper published in the Journal of Biological Chemistry . The allegation was that they had rehashed the same set of data which they had published earlier. [12] An internal committee of the NCCS advised the authors to take back their paper, however an independent committee led by G. Padmanabhan, a former director of Indian Institute of Science, Bangalore, concluded that there was no manipulation in the data. [13] On 23 February 2007, the Journal of Biological Chemistry withdrew the paper amid allegations of data manipulation, although the authors maintained that the two papers used different set of data though similar experiments.

Selected publications

See also

Related Research Articles

<span class="mw-page-title-main">PTPN11</span> Protein-coding gene in the species Homo sapiens

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.

<span class="mw-page-title-main">Nuclear receptor coactivator 3</span> Protein-coding gene in the species Homo sapiens

The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).

<span class="mw-page-title-main">AKT1</span> Protein-coding gene in the species Homo sapiens

RAC(Rho family)-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 protein domains. It is commonly referred to as PKB, or by both names as "Akt/PKB".

<span class="mw-page-title-main">MAPK1</span> Protein-coding gene in the species Homo sapiens

Mitogen-activated protein kinase 1, also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.

<span class="mw-page-title-main">FYN</span> Mammalian protein found in Homo sapiens

Proto-oncogene tyrosine-protein kinase Fyn is an enzyme that in humans is encoded by the FYN gene.

<span class="mw-page-title-main">PRKCD</span> Protein-coding gene in the species Homo sapiens

Protein kinase C delta type is an enzyme that in humans is encoded by the PRKCD gene.

<span class="mw-page-title-main">MAPK8</span> Protein-coding gene in the species Homo sapiens

Mitogen-activated protein kinase 8 is a ubiquitous enzyme that in humans is encoded by the MAPK8 gene.

<span class="mw-page-title-main">PTPN6</span> Protein-coding gene in the species Homo sapiens

Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), is an enzyme that in humans is encoded by the PTPN6 gene.

<span class="mw-page-title-main">Mucin short variant S1</span> Human protein

Mucin short variant S1, also called polymorphic epithelial mucin (PEM) or epithelial membrane antigen (EMA), is a mucin encoded by the MUC1 gene in humans. Mucin short variant S1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers. Joyce Taylor-Papadimitriou identified and characterised the antigen during her work with breast and ovarian tumors.

<span class="mw-page-title-main">RAS p21 protein activator 1</span> Protein-coding gene in the species Homo sapiens

RAS p21 protein activator 1 or RasGAP, also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities:

<span class="mw-page-title-main">CYR61</span> Protein-coding gene in the species Homo sapiens

Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene.

<span class="mw-page-title-main">STAT5A</span> Protein-coding gene in the species Homo sapiens

Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5A gene. STAT5A orthologs have been identified in several placentals for which complete genome data are available.

<span class="mw-page-title-main">PTK2B</span> Protein-coding gene in the species Homo sapiens

Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the PTK2B gene.

<span class="mw-page-title-main">MAP3K11</span> Protein-coding gene in humans

Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene.

<span class="mw-page-title-main">BCAR1</span> Protein-coding gene in the species Homo sapiens

Breast cancer anti-estrogen resistance protein 1 is a protein that in humans is encoded by the BCAR1 gene.

<span class="mw-page-title-main">Activating transcription factor 2</span> Protein-coding gene in the species Homo sapiens

Activating transcription factor 2, also known as ATF2, is a protein that, in humans, is encoded by the ATF2 gene.

<span class="mw-page-title-main">ST14</span> Protein-coding gene in the species Homo sapiens

Suppressor of tumorigenicity 14 protein, also known as matriptase, is a protein that in humans is encoded by the ST14 gene. ST14 orthologs have been identified in most mammals for which complete genome data are available.

<span class="mw-page-title-main">TNK2</span> Protein-coding gene in the species Homo sapiens

Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene. TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

<span class="mw-page-title-main">BMX (gene)</span> Type of enzyme

Cytoplasmic tyrosine-protein kinase BMX is an enzyme that in humans is encoded by the BMX gene.

Angiogenesis is the process of forming new blood vessels from existing blood vessels, formed in vasculogenesis. It is a highly complex process involving extensive interplay between cells, soluble factors, and the extracellular matrix (ECM). Angiogenesis is critical during normal physiological development, but it also occurs in adults during inflammation, wound healing, ischemia, and in pathological conditions such as rheumatoid arthritis, hemangioma, and tumor growth. Proteolysis has been indicated as one of the first and most sustained activities involved in the formation of new blood vessels. Numerous proteases including matrix metalloproteinases (MMPs), a disintegrin and metalloproteinase domain (ADAM), a disintegrin and metalloproteinase domain with throbospondin motifs (ADAMTS), and cysteine and serine proteases are involved in angiogenesis. This article focuses on the important and diverse roles that these proteases play in the regulation of angiogenesis.

References

  1. ↑ "Brief Profile of the Awardee". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 5 October 2016.
  2. ↑ "Handbook of Shanti Swarup Bhatnagar Prize Winners" (PDF). Council of Scientific and Industrial Research. 1999. p. 34. Archived from the original (PDF) on 4 March 2016. Retrieved 5 October 2016.
  3. ↑ "Fellow profile - G C Kundu". Indian Academy of Sciences. 2016. Retrieved 6 October 2016.
  4. ↑ "NASI fellows". National Academy of Sciences, India. 2016. Archived from the original on 15 March 2016. Retrieved 20 October 2016.
  5. ↑ "N-BIOS Prize" (PDF). Department of Biotechnology. 2016. Archived from the original (PDF) on 4 March 2018. Retrieved 20 October 2016.
  6. ↑ "View Bhatnagar Awardees". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 5 October 2016.
  7. ↑ "Dr. Gopal Kundu". NCCS. 1 January 2001. Archived from the original on 27 September 2011. Retrieved 8 November 2011.
  8. ↑ "DBT neurobiology task force". Neurobiology. 5 March 2004.
  9. ↑ "Curriculum vitae". apoptosis. 20 August 2005. Archived from the original on 25 April 2012. Retrieved 9 November 2011.
  10. ↑ "PM presents Bhatnagar prizes to 21 scientists". The Times of India . 29 September 2005. Archived from the original on 3 January 2013.
  11. 1 2 "Two Pune scientists bag Bhatnagar prize". The Times of India . 29 September 2004. Archived from the original on 3 January 2013.
  12. ↑ "Kundu-JBC Case". Society for Scientific Values.
  13. ↑ G.S. mudur (6 March 2007). "Indicted there, acquitted here". The Telegraph . Calcutta, India. Archived from the original on 25 May 2011.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.