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Shubha Tole | |
---|---|
Born | August 1967 56) | (age
Nationality | Indian |
Education | St Xavier's, Mumbai California Institute of Technology, USA |
Occupation | Neuroscientist |
Employer | Tata Institute of Fundamental Research |
Spouse | Sandip Trivedi |
Children | 2 |
Shubha Tole' (born August 1967) is an Indian neuroscientist, professor and principal Investigator at the Tata Institute of Fundamental Research in Mumbai, India. Her research investigates the development and evolution of the mammalian brain. In 2014, she won the Infosys Prize in the Life Sciences category.
Tole was born in August 1967 in India. Her mother, Aruna P. Tole, was an occupational therapist responsible for the design of prostheses, aids, and appliances for cancer patients. [1] Her father was the director of SAMEER, an institute under the Department of Electronics, Government of India, [2] in August 1967.
Tole studied life sciences and biochemistry at St. Xavier’s College in Mumbai and earned her master's and doctoral degrees at the California Institute of Technology in the United States. Tole conducted post-doctoral research at the University of Chicago. [3]
In 1999, Dr. Tole started her research group at the Tata Institute of Fundamental Research, Mumbai. [4]
Dr. Tole and her research group is credited with the discovery of the role of the regulatory gene LHX2, which controls aspects of how the amygdala, cortex, and hippocampus form during early brain development. Dr. Tole's research group also proposed a possible mechanism for how the neocortex may have come to be in mammals, linking it to a much older structure of the brain, the amygdala. Her research group also discovered dual developmental origins for structures that control reproductive and aggressive behavior in the accessory olfactory bulb in mammals. [5]
Tole has also held a membership with academic groups such as the International Affairs Committee of the American Society for Cell Biology. She is also a Fellow of the National Academy of Sciences, India and the Indian Academy of Sciences. [3]
Dr. Tole is married to theoretical physicist Sandip Trivedi since 1989. They have two sons. [6]
Tole has received the Wellcome Trust Senior International Fellowship (1999), the Swarnajayanti Fellowship from the Department of Science and Technology of the Government of India (2005), the National Woman Bioscientist award from the Department of Biotechnology of Government of India (2008), the Research Award for Innovation in Neurosciences (RAIN award) from the Society for Neuroscience, United States (2008), and the Shanti Swarup Bhatnagar Award (2010). [3] She was also awarded the Wellcome Trust Flexible Travel Award grant by Stanford University for a Sabbatical year in 2008. [7] In 2014, Tole was awarded the Infosys Prize of 55 lakh rupees for her work elucidating the mechanisms and genes involved in the formation of the hippocampus. [3]
The limbic system, also known as the paleomammalian cortex, is a set of brain structures located on both sides of the thalamus, immediately beneath the medial temporal lobe of the cerebrum primarily in the forebrain.
The olfactory bulb is a neural structure of the vertebrate forebrain involved in olfaction, the sense of smell. It sends olfactory information to be further processed in the amygdala, the orbitofrontal cortex (OFC) and the hippocampus where it plays a role in emotion, memory and learning. The bulb is divided into two distinct structures: the main olfactory bulb and the accessory olfactory bulb. The main olfactory bulb connects to the amygdala via the piriform cortex of the primary olfactory cortex and directly projects from the main olfactory bulb to specific amygdala areas. The accessory olfactory bulb resides on the dorsal-posterior region of the main olfactory bulb and forms a parallel pathway. Destruction of the olfactory bulb results in ipsilateral anosmia, while irritative lesions of the uncus can result in olfactory and gustatory hallucinations.
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