Shubha Tole

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Shubha Tole
BornAugust 1967 (1967-08) (age 56)
NationalityIndian
EducationSt Xavier's, Mumbai California Institute of Technology, USA
OccupationNeuroscientist
EmployerTata Institute of Fundamental Research
SpouseSandip Trivedi
Children2

Shubha Tole' (born August 1967) is an Indian neuroscientist, professor and principal Investigator at the Tata Institute of Fundamental Research in Mumbai, India. Her research investigates the development and evolution of the mammalian brain. In 2014, she won the Infosys Prize in the Life Sciences category.

Contents

Early life and education

Tole was born in August 1967 in India. Her mother, Aruna P. Tole, was an occupational therapist responsible for the design of prostheses, aids, and appliances for cancer patients. [1] Her father was the director of SAMEER, an institute under the Department of Electronics, Government of India, [2] in August 1967.

Tole studied life sciences and biochemistry at St. Xavier’s College in Mumbai and earned her master's and doctoral degrees at the California Institute of Technology in the United States. Tole conducted post-doctoral research at the University of Chicago. [3]

Research and career

In 1999, Dr. Tole started her research group at the Tata Institute of Fundamental Research, Mumbai. [4]

Dr. Tole and her research group is credited with the discovery of the role of the regulatory gene LHX2, which controls aspects of how the amygdala, cortex, and hippocampus form during early brain development. Dr. Tole's research group also proposed a possible mechanism for how the neocortex may have come to be in mammals, linking it to a much older structure of the brain, the amygdala. Her research group also discovered dual developmental origins for structures that control reproductive and aggressive behavior in the accessory olfactory bulb in mammals. [5]

Tole has also held a membership with academic groups such as the International Affairs Committee of the American Society for Cell Biology. She is also a Fellow of the National Academy of Sciences, India and the Indian Academy of Sciences. [3]

Personal life

Dr. Tole is married to theoretical physicist Sandip Trivedi since 1989. They have two sons. [6]

Honors and awards

Tole has received the Wellcome Trust Senior International Fellowship (1999), the Swarnajayanti Fellowship from the Department of Science and Technology of the Government of India (2005), the National Woman Bioscientist award from the Department of Biotechnology of Government of India (2008), the Research Award for Innovation in Neurosciences (RAIN award) from the Society for Neuroscience, United States (2008), and the Shanti Swarup Bhatnagar Award (2010). [3] She was also awarded the Wellcome Trust Flexible Travel Award grant by Stanford University for a Sabbatical year in 2008. [7] In 2014, Tole was awarded the Infosys Prize of 55 lakh rupees for her work elucidating the mechanisms and genes involved in the formation of the hippocampus. [3]

Publications

Related Research Articles

<span class="mw-page-title-main">Limbic system</span> Set of brain structures involved in emotion and motivation

The limbic system, also known as the paleomammalian cortex, is a set of brain structures located on both sides of the thalamus, immediately beneath the medial temporal lobe of the cerebrum primarily in the forebrain.

<span class="mw-page-title-main">Olfactory bulb</span> Neural structure

The olfactory bulb is a neural structure of the vertebrate forebrain involved in olfaction, the sense of smell. It sends olfactory information to be further processed in the amygdala, the orbitofrontal cortex (OFC) and the hippocampus where it plays a role in emotion, memory and learning. The bulb is divided into two distinct structures: the main olfactory bulb and the accessory olfactory bulb. The main olfactory bulb connects to the amygdala via the piriform cortex of the primary olfactory cortex and directly projects from the main olfactory bulb to specific amygdala areas. The accessory olfactory bulb resides on the dorsal-posterior region of the main olfactory bulb and forms a parallel pathway. Destruction of the olfactory bulb results in ipsilateral anosmia, while irritative lesions of the uncus can result in olfactory and gustatory hallucinations.

<span class="mw-page-title-main">Fear conditioning</span> Behavioral paradigm in which organisms learn to predict aversive events

Pavlovian fear conditioning is a behavioral paradigm in which organisms learn to predict aversive events. It is a form of learning in which an aversive stimulus is associated with a particular neutral context or neutral stimulus, resulting in the expression of fear responses to the originally neutral stimulus or context. This can be done by pairing the neutral stimulus with an aversive stimulus. Eventually, the neutral stimulus alone can elicit the state of fear. In the vocabulary of classical conditioning, the neutral stimulus or context is the "conditional stimulus" (CS), the aversive stimulus is the "unconditional stimulus" (US), and the fear is the "conditional response" (CR).

<span class="mw-page-title-main">Kiran Mazumdar-Shaw</span> Indian entrepreneur (Biocon), billionaire

Kiran Mazumdar-Shaw is an Indian billionaire entrepreneur. She is the executive chairperson and founder of Biocon Limited and Biocon Biologics Limited, a biotechnology company based in Bangalore, India and the former chairperson of Indian Institute of Management, Bangalore. In 2014, she was awarded the Othmer Gold Medal for outstanding contributions to the progress of science and chemistry. She was on the Financial Times 2011 top 50 women in business list. In 2019, she was listed as the 68th most powerful woman in the world by Forbes. She was named EY World Entrepreneur Of The Year 2020. She is married to John Shaw.

<span class="mw-page-title-main">Thanu Padmanabhan</span> Indian physicist and cosmologist (1957–2021)

Thanu Padmanabhan was an Indian theoretical physicist and cosmologist whose research spanned a wide variety of topics in gravitation, structure formation in the universe and quantum gravity. He published nearly 300 papers and reviews in international journals and ten books in these areas. He made several contributions related to the analysis and modelling of dark energy in the universe and the interpretation of gravity as an emergent phenomenon. He was a Distinguished Professor at the Inter-University Centre for Astronomy and Astrophysics (IUCAA) at Pune, India.

<span class="mw-page-title-main">Ganglionic eminence</span>

The ganglionic eminence (GE) is a transitory structure in the development of the nervous system that guides cell and axon migration. It is present in the embryonic and fetal stages of neural development found between the thalamus and caudate nucleus.

<span class="mw-page-title-main">Environmental enrichment</span> Brain stimulation through physical and social surroundings

Environmental enrichment is the stimulation of the brain by its physical and social surroundings. Brains in richer, more stimulating environments have higher rates of synaptogenesis and more complex dendrite arbors, leading to increased brain activity. This effect takes place primarily during neurodevelopment, but also during adulthood to a lesser degree. With extra synapses there is also increased synapse activity, leading to an increased size and number of glial energy-support cells. Environmental enrichment also enhances capillary vasculation, providing the neurons and glial cells with extra energy. The neuropil expands, thickening the cortex. Research on rodent brains suggests that environmental enrichment may also lead to an increased rate of neurogenesis.

Sandip Trivedi is an Indian theoretical physicist working at Tata Institute for Fundamental Research (TIFR) at Mumbai, India, while he is its current director. He is well known for his contributions to string theory, in particular finding the first models of accelerated expansion of the universe in low energy supersymmetric string. His research areas include string theory, cosmology and particle physics. He is now member of program advisory board of International Center for Theoretical Sciences (ICTS). He is also the recipient of the Infosys Prize 2010 in the category of Physical Sciences.

<span class="mw-page-title-main">Infosys Prize</span> Annual award given by the Infosys Science Foundation

The Infosys Prize is an annual award given to scientists, researchers, engineers and social scientists of Indian origin by the Infosys Science Foundation and ranks among the highest monetary awards in India to recognize research. The prize for each category includes a gold medallion, a citation certificate, and prize money of US$100,000. The prize purse is tax free in the hands of winners in India. The winners are selected by the jury of their respective categories, headed by the jury chairs.

<span class="mw-page-title-main">Vidita Vaidya</span> Indian scientist

Vidita Vaidya is an Indian neuroscientist and professor at the Tata Institute of Fundamental Research, Mumbai. Her primary areas of research are neuroscience and molecular psychiatry.

<span class="mw-page-title-main">Rohini Godbole</span> Indian physicist

Rohini Godbole is an Indian physicist and academic specializing in elementary particle physics: field theory and phenomenology. She is currently a professor at the Centre for High Energy Physics, Indian Institute of Science, Bangalore. She has worked extensively on different aspects of particle phenomenology over the past three decades, in particular on exploring different aspects of the Standard Model of Particle Physics (SM) and the physics beyond it (BSM). Her work regarding hadronic structure of high-energy photons outlined a variety of ways in which to study it and has had implications for the design of next generation electron positron colliders. She is an elected fellow of all the three academies of Science of India and also the Science Academy of the Developing World (TWAS).

Gaiti Hasan is an Indian scientist who researches in the fields of molecular biology, genetics, neuroscience and cell signalling. Hasan is a Fellow of the Indian National Science Academy (INSA), the apex body of Indian scientists and technologists. From 2013 onwards she has been serving as a Senior Professor at the National Centre for Biological Sciences (NCBS), Bangalore.

Sanjeev Anant Galande is an Indian cell biologist, epigeneticist, academic, former Chair of Biology and the Dean of Research and Development at the Indian Institute of Science Education and Research, Pune. He heads the Laboratory of Chromatin Biology and Epigenetics at the Indian Institute of Science Education and Research, Pune. He is the founder of the Centre of Excellence in Epigenetics at IISER Pune and is known for his studies on higher-order chromatin architecture and how it influences spatiotemporal changes in gene expression. He is an elected fellow of the Indian National Science Academy and the Indian Academy of Sciences and a recipient of the National Bioscience Award for Career Development of the Department of Biotechnology. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2010, for his contributions to biological sciences.

<span class="mw-page-title-main">Upinder Singh Bhalla</span>

Upinder Singh Bhalla is an Indian computational neuroscientist, academic and a professor at National Centre for Biological Sciences of the Tata Institute of Fundamental Research. He is known for his studies on neuronal and synaptic signalling in memory and olfactory coding using computational and experimental methods and is an elected fellow of the Indian Academy of Sciences and the Indian National Science Academy. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2007, for his contributions to biological sciences. The Infosys Science Foundation awarded him the Infosys Prize 2017 in Life Sciences for his pioneering contributions to the understanding of the brain's computational machinery.

Ashish Kishore Lele is an Indian chemical engineer, rheologist and the Director of the National Chemical Laboratory, Pune. He is known for his researches on micro and mesostructure of polymers and is an elected fellow of the Indian Academy of Sciences, and the Indian National Academy of Engineering. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Engineering Sciences in 2006. He received the Infosys Prize in 2012.

Moriel Zelikowsky is a neuroscientist at University of Utah School of Medicine. Her laboratory studies the brain circuits and neural mechanisms underlying stress, fear, and social behavior. Her previous work includes fear and the hippocampus, and the role of neuropeptide Tac2 in social isolation.

References

  1. Meet India's best scientist, Shubha Tole, Careers 360, archived from the original on 28 April 2017, retrieved 18 November 2015
  2. Science of life, Mumbai Mirror, archived from the original on 4 March 2016, retrieved 17 November 2015
  3. 1 2 3 4 Infosys Prize, Infosys Science Foundation, archived from the original on 19 November 2015, retrieved 17 November 2015
  4. Do not precompromise on your dreams: Dr.Shubha Tole, BioSpectrum, archived from the original on 19 November 2015, retrieved 17 November 2015
  5. Shetty, Ashwin S.; Godbole, Geeta; Maheshwari, Upasana; Padmanabhan, Hari; Chaudhary, Rahul; et al. (21 November 2003). "Lhx2 regulates a cortex-specific mechanism for barrel formation". PNAS. 110 (50): E4913–E4921. doi: 10.1073/pnas.1311158110 . PMC   3864327 . PMID   24262147.
  6. String Duet, LiveMint, 8 February 2013, archived from the original on 19 November 2015, retrieved 18 November 2015
  7. Shubha Tole, F1000 Prime, archived from the original on 19 November 2015, retrieved 18 November 2015
  8. Muralidharan B, Khatri Z, Maheshwari U, Gupta R, Roy B, Pradhan SJ, Karmodiya K, Padmanabhan H, Shetty AS, Balaji C, Kolthur-Seetharam U, Macklis JD, Galande S, Tole S. .J Neurosci. 2017 Jan 4;37(1):194-203. doi: 10.1523/JNEUROSCI.2836-16.2016
  9. Muralidharan B, Keruzore M, Pradhan SJ, Roy B, Shetty AS, Kinare V, D'Souza L, Maheshwari U, Karmodiya K, Suresh A, Galande S, Bellefroid EJ, Tole S. J Neurosci. 2017 Nov 15;37(46):11245-11254. doi: 10.1523/JNEUROSCI.1535-17.2017. Epub 2017 Oct 12. PMID 29025924
  10. Novel functions of LHX2 and PAX6 in the developing telencephalon revealed upon combined loss of both genes. Godbole G, Roy A, Shetty AS, Tole S. Neural Dev. 2017 Nov 15;12(1):19. doi: 10.1186/s13064-017-0097-y.PMID 29141678