Arun Kumar Shukla

Last updated

Arun Kumar Shukla
Born
Kushinagar, Uttar Pradesh, India
Nationality Indian
Alma mater
Known forStudies on G protein-coupled receptor
Awards
Scientific career
Fields
Institutions
Doctoral advisor

Arun Kumar Shukla is an Indian structural biologist and the Joy-Gill Chair professor at the department of biological sciences and bioengineering at the Indian Institute of Technology, Kanpur. [1] Known for his studies on G protein-coupled receptor, Shukla is a Wellcome Trust-DBT Intermediate Fellow and a recipient of the SwarnaJayanti Fellowship of the Department of Science and Technology. [2] The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences, in 2017/18. He received the 2021 Shanti Swarup Bhatnagar Prize for Science and Technology in Biological Science. [3] He was awarded the Infosys Prize 2023 in Life Sciences his outstanding contributions to the biology of G-protein coupled receptors (GPCRs).

Contents

Biography

IIT Kanpur A building at IIT Kanpur.jpg
IIT Kanpur

Dr. Arun Kumar Shukla was born on 01 November 1981 [4] in Kushinagar in the Indian state of Uttar Pradesh, [5] earned his master's degree in biotechnology from Jawaharlal Nehru University after which he did his doctoral studies under the guidance of Hartmut Michel (Nobel Laureate, 1988) of Max Planck Institute of Biophysics. [1] His post-doctoral work was with Robert J. Lefkowitz (Nobel Laureate, 2012) of Duke University and Brian Kobilka (Nobel Laureate, 2012) of Stanford University and he started his career at Duke University as an assistant professor at their department of medicine. Returning to India, he joined the Indian Institute of Technology, Kanpur (IITK) at the Department of Biological Sciences and Bioengineering (BSBE) [6] where he holds the position of a professor [7] and heads the Laboratory of GPCR Biology. [8]

Shukla is known to have carried out extensive research on G protein-coupled receptor and his research is reported to have led to easier regulation of these receptors for better drug efficacy. [9] He led a team of IITK scientists who developed nanomachines which could be designed to selectively target signalling events inside living cells. [10] The technique developed by them is in use with several drugs that are available in the market such as Telmisartan, Olmesartan, Fexofenadine, Propranolol, and Metoprolol. [5] He has published a number of articles and has contributed chapters to books published by others; [11] [note 1] Google Scholar, an online repository of scientific articles has listed 75 of them. [12]

Awards and honours

Shukla received the Infosys Prize 2023 in Life Sciences, he was selected for this prestigious award by an eminent jury chaired by MIT Professor, Mriganka Sur. He received the 2021 Shanti Swarup Bhatnagar Prize for Science and Technology in Biological Science. [3] The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences, in 2017/18. [13] He has also received the B. M. Birla Science Prize (2017), [14] NASI-Young Scientist Platinum Jubilee Award of the National Academy of Sciences, India (2016), [15] CDRI Award (2018), [16] Shakuntala Amir Chand Prize of the Indian Council for Medical Research (2018) [17] [18] and the EMBO Young Investigator Award (2017). [19] He was elected as a fellow of the Indian National Science Academy in 2022. [20]

Selected bibliography

See also

Notes

  1. ↑ Please see Selected bibliography section

Related Research Articles

<span class="mw-page-title-main">G protein-coupled receptor</span> Class of cell surface receptors coupled to G-protein-associated intracellular signaling

G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses. They are coupled with G proteins. They pass through the cell membrane seven times in the form of six loops of amino acid residues, which is why they are sometimes referred to as seven-transmembrane receptors. Ligands can bind either to the extracellular N-terminus and loops or to the binding site within transmembrane helices. They are all activated by agonists, although a spontaneous auto-activation of an empty receptor has also been observed.

Neeraj Kayal is an Indian computer scientist and mathematician noted for development of the AKS primality test, along with Manindra Agrawal and Nitin Saxena. Kayal was born and raised in Guwahati, India.

The actions of vasopressin are mediated by stimulation of tissue-specific G protein-coupled receptors (GPCRs) called vasopressin receptors that are classified into the V1 (V1A), V2, and V3 (V1B) receptor subtypes. These three subtypes differ in localization, function and signal transduction mechanisms.

<span class="mw-page-title-main">Arrestin</span> Family of proteins

Arrestins are a small family of proteins important for regulating signal transduction at G protein-coupled receptors. Arrestins were first discovered as a part of a conserved two-step mechanism for regulating the activity of G protein-coupled receptors (GPCRs) in the visual rhodopsin system by Hermann Kühn, Scott Hall, and Ursula Wilden and in the β-adrenergic system by Martin J. Lohse and co-workers.

<span class="mw-page-title-main">G protein-coupled receptor kinase</span> Family of protein kinases

G protein-coupled receptor kinases are a family of protein kinases within the AGC group of kinases. Like all AGC kinases, GRKs use ATP to add phosphate to Serine and Threonine residues in specific locations of target proteins. In particular, GRKs phosphorylate intracellular domains of G protein-coupled receptors (GPCRs). GRKs function in tandem with arrestin proteins to regulate the sensitivity of GPCRs for stimulating downstream heterotrimeric G protein and G protein-independent signaling pathways.

<span class="mw-page-title-main">G protein-coupled receptor kinase 2</span> Enzyme

G-protein-coupled receptor kinase 2 (GRK2) is an enzyme that in humans is encoded by the ADRBK1 gene. GRK2 was initially called Beta-adrenergic receptor kinase, and is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinases that is most highly similar to GRK3(βARK2).

<span class="mw-page-title-main">Robert Lefkowitz</span> American physician and biochemist

Robert Joseph Lefkowitz is an American physician and biochemist. He is best known for his discoveries that reveal the inner workings of an important family of G protein-coupled receptors, for which he was awarded the 2012 Nobel Prize for Chemistry with Brian Kobilka. He is currently an Investigator with the Howard Hughes Medical Institute as well as a James B. Duke Professor of Medicine and Professor of Biochemistry and Chemistry at Duke University.

<span class="mw-page-title-main">Vinod K. Singh</span> Indian chemist and professor (born 1959)

Vinod K. Singh is a Rahula and Namita Gautam Chair Professor of Chemistry at IIT Kanpur. He is also the Director's Chair Professor at IISER Bhopal & adjunct professor at NIPER Hyderabad. He is currently the President, Chemical Research Society of India and the Chairman, Governing Council of IACS Kolkata.

Trevena, Inc. is a clinical stage biopharmaceutical company, headquartered in Chesterbrook, Pennsylvania, USA, and is involved in the discovery and development of G-protein coupled receptors (GPCR) biased ligands. Trevena was founded in 2007 with technology licensed from Duke University, which originated in the labs of company founders Robert Lefkowitz winner of the 2012 Nobel Prize in Chemistry and Howard Rockman. Trevena's approach to drug discovery is based on utilizing ligand bias, or functional selectivity, at GPCR targets to produce drugs with improved efficacy and reduced side effect profiles. Trevena was named one of the top 15 US startups of 2008 by Business Week.

Martin J. Lohse is a German physician and pharmacologist.

Kanury Raoalso known as Kanury Venkata Subba Rao is an Indian immunologist. He was the head of the Drug Discovery Research Centre (DDRC) at the Translational Health Science and Technology Institute (THSTI) Faridabad. He is known for his studies in the fields of peptide synthesis and cell signaling and the design of synthetic peptide vaccines. He is an elected fellow of the Indian Academy of Sciences, National Academy of Sciences, India and the Indian National Science Academy. and a recipient of several awards including the Millennium Plaque of Honour of the Indian Science Congress and the National Bioscience Award for Career Development. The Council of Scientific and Industrial Research awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, in 1997, for his contributions to biological sciences.

Sanjeev Anant Galande is an Indian cell biologist, epigeneticist, academic, former Chair of Biology and the Dean of Research and Development at the Indian Institute of Science Education and Research, Pune. He heads the Laboratory of Chromatin Biology and Epigenetics at the Indian Institute of Science Education and Research, Pune. He is the founder of the Centre of Excellence in Epigenetics at IISER Pune and is known for his studies on higher-order chromatin architecture and how it influences spatiotemporal changes in gene expression. He is an elected fellow of the Indian National Science Academy and the Indian Academy of Sciences and a recipient of the National Bioscience Award for Career Development of the Department of Biotechnology. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2010, for his contributions to biological sciences.

Balasubramanian Gopal is an Indian structural biologist, molecular biophysicist and a professor at the Molecular Biophysics Unit of the Indian Institute of Science. He is known for his studies on cell wall synthesis in Staphylococcus aureus and is an elected fellow of the National Academy of Sciences, India, Indian National Science Academy and the Indian Academy of Sciences. He received the National Bioscience Award for Career Development of the Department of Biotechnology in 2010. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2015, for his contributions to biological sciences.

Palliakaranai Thirumalai Narasimhan (1928–2013), popularly known as PTN or Jim, was an Indian theoretical chemist, one of the pioneers of computational chemistry in India and a professor at the Indian Institute of Technology, Kanpur. He was known for his studies on quantum-mechanical interpretation of magnetic resonance data and his contributions in developing IIT Kanpur into a Centre of Excellence in academic research in the basic sciences. He was an elected fellow of the Indian National Science Academy, Indian Academy of Sciences and the National Academy of Sciences, India. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 1970, for his contributions to chemical sciences.

Jarugu Narasimha Moorthy is an Indian organic photochemist and the Director of Indian Institute of Science Education and Research, Thiruvananthapuram. He was a Dr. Jag Mohan Garg Chair Professor at the Indian Institute of Technology, Kanpur. He is known for his studies on organic photochemistry and supramolecular chemistry. He is an elected fellow of the Royal Society of Chemistry and the Indian Academy of Sciences. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2008, for his contributions to chemical sciences.

Sandeep Verma is an Indian bioorganic chemist and chemical biologist, and a Professor in the Department of Chemistry at the Indian Institute of Technology, Kanpur (IITK). At IITK, he heads Sandeep Verma's Research Group in the areas of ordered peptide assemblies, metal-mediated nanoscale systems, programmable soft matter for neuronal regeneration, novel antimicrobials, and small molecule-stem cell modulation. He is an elected fellow of the Indian National Science Academy (INSA), the Indian Academy of Sciences, the National Academy of Sciences, India, and the Indian National Academy of Engineering. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2010, for his contributions to Chemical Sciences.

<span class="mw-page-title-main">Yogesh M. Joshi</span> Indian chemical engineer (born 1974)

Yogesh Moreshwar Joshi is an Indian chemical engineer, rheologist and the Mr. & Mrs. Gian Singh Bindra Chair Professor at the Indian Institute of Technology, Kanpur. He is known for his studies on metastable soft matter and is an elected fellow of the Society of Rheology, Indian National Science Academy, Indian Academy of Sciences,The National Academy of Sciences, India, and Indian National Academy of Engineering. In 2015, the Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded Joshi the Shanti Swarup Bhatnagar Prize for Science and Technology for his contributions to Engineering Sciences. In 2023, he received prestigious J C Bose fellowship constituted by the Science and Engineering Research Board, Government of India.

Ramasubbu Sankararamakrishnan is an Indian computational biologist, bioinformatician and a professor at the Department of Biological Sciences and Bioengineering of the Indian Institute of Technology, Kanpur. He is known for his computational studies on membrane protein function. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences in 2008.

Subramaniam Ganesh is an Indian geneticist, molecular biologist and a professor at the department of biological sciences and bio-engineering of the Indian Institute of Technology, Kanpur. Known for his pioneering studies on Lafora progressive myoclonic epilepsy and other neurodegenerative disorders, Ganesh is an elected fellow of the Indian Academy of Sciences and the National Academy of Sciences, India. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences in 2008.

Bushra Ateeq is a Professor and a Senior Fellow of the DBT/Wellcome Trust India Alliance in the Department of Biological Sciences and Bioengineering (BSBE), IIT Kanpur specializing in cancer biology and molecular oncology. She was awarded the Shanti Swarup Bhatnagar Prize for Science and Technology in Medical Sciences in the year 2020. Her research interest involves exploration of the genetic and epigenetic changes that initiate cancer and its progression. She is also focusing on understanding the molecular events that drive cancer and resistance towards chemotherapeutic drugs.

References

  1. 1 2 "Arun K. Shukla IITK". www.iitk.ac.in. 30 December 2018. Retrieved 30 December 2018.
  2. ↑ "List of Awardees - SwarnaJayanti Fellowships Scheme – 2017-18" (PDF). Department of Science and Technology. 30 December 2018. Retrieved 30 December 2018.
  3. 1 2 "Shanti Swarup Bhatnagar Prize (SSB) for Science and Technology 2021" (PDF). sbprize.gov.in. Council of Scientific and Industrial Research . Retrieved 26 September 2021.
  4. ↑ "Arun Kumar Shukla Biography". Online Hindi world. 27 November 2021.
  5. 1 2 "Better pill". www.telegraphindia.com. 30 December 2018. Retrieved 30 December 2018.
  6. ↑ "BSBE People". www.iitk.ac.in. 30 December 2018. Retrieved 30 December 2018.
  7. ↑ "Arun Shukla on Samviti". samviti.com. 30 December 2018. Retrieved 30 December 2018.
  8. ↑ "Principal Investigator - Laboratory of GPCR Biology". sites.google.com. 30 December 2018. Retrieved 30 December 2018.
  9. ↑ Prasad, R. (1 January 2017). "Drug discovery for GPCR signalling made easy by IIT Kanpur". The Hindu. Retrieved 30 December 2018.
  10. ↑ Jayan, T. V. (8 January 2018). "IIT-Kanpur scientist-led team designs nano-machines that can correct anomalies inside living cells". @businessline. Retrieved 30 December 2018.
  11. ↑ "Research Publications - Laboratory of GPCR Biology". sites.google.com. 31 December 2018. Retrieved 31 December 2018.
  12. ↑ "Arun K. Shukla - Google Scholar Citations". scholar.google.co.in. 31 December 2018. Retrieved 31 December 2018.
  13. ↑ "Awardees of National Bioscience Awards for Career Development" (PDF). Department of Biotechnology. 2016. Archived from the original (PDF) on 4 March 2018. Retrieved 20 November 2017.
  14. ↑ "BM Birla Science Prize presented". www.thehansindia.com. 31 December 2018. Retrieved 31 December 2018.
  15. ↑ "The National Academy of Sciences, India - Activities". www.nasi.org.in. 31 December 2018. Archived from the original on 9 January 2019. Retrieved 31 December 2018.
  16. ↑ "List of previous CDRI Awardees" (PDF). Central Drug Research Institute. 31 December 2018. Archived from the original (PDF) on 31 December 2018. Retrieved 31 December 2018.
  17. ↑ "Awards - Indian Council of Medical Research". ICMR. 31 December 2018. Archived from the original on 31 December 2018. Retrieved 31 December 2018.
  18. ↑ Vishwas (31 December 2018). "News Archive". www.iitk.ac.in. Retrieved 31 December 2018.
  19. ↑ "IITK faculty Dr. Arun Shukla, Department of Biosciences & bioengineering has been selected as the EMBO Young Investigator". Pinterest. 30 December 2018. Retrieved 30 December 2018.
  20. ↑ "INSA :: Indian Fellows Elected". www.insaindia.res.in. Retrieved 22 October 2022.

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