Garikapati Narahari Sastry

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Garikapati Narahari Sastry
G. Narahari Sastry.jpg
Sastry in 2019
Born1966 (age 57–58)
Andhra Pradesh, India
NationalityIndian
Alma mater Osmania University, University of Hyderabad
Known forMolecular Modeling and Computer-Aided Drug Design
Scientific career
Fields Chemistry, theoretical chemistry, Computer Aided Drug Design
Institutions IIT-Hyderabad
North East Institute of Science and Technology, Jorhat
Indian Institute of Chemical Technology
Pondicherry University
Doctoral advisor Eluvathingal Devassy Jemmis,
Other academic advisors Sason Shaik
Website https://neist.res.in/gnsastry/

Garikapati Narahari Sastry is an Indian Chemist and a Professor at the Department of Biotechnology at IIT-Hyderabad. [1] He served as Director of CSIR- North East Institute of Science and Technology, Jorhat [2] Jorhat, Assam from 19 February 2019 and served there till 10 January 2024. [3] [4] After taking charge as the Director, he has worked towards converting knowledge in the areas of computational modelling and Artificial intelligence from basic to translational research, by working closely with society and industry. Ultimately, revitalizing the strength of science and technology is essential in achieving the self-reliant and strong India. In the era of Industry 4.0 and 5.0, combining our traditional wisdom with modern science appear to be indispensable in the sectors such as Education, Health, Agriculture, Industrial and Societal development at large. Prior to joining as the Director, he headed the Molecular Modelling Division at the CSIR Indian Institute of Chemical Technology in Hyderabad, India. Sastry has made pioneering contributions in the areas of computational chemistry and computational biology.

Contents

He was awarded Shanti Swarup Bhatnagar Prize for Science and Technology in 2011, the highest science award in India, in the chemical sciences category. [5]

Early life and education

G. N. Sastry completed his BSc (1985) and MSc (1988) from Osmania University. He earned his PhD from University of Hyderabad in Theoretical and Computational Chemistry under the supervision of Prof. E. D. Jemmis in 1995. Subsequently, he moved to Israel to carry out his first postdoctoral studies (1994 – 1996) with Prof. Sason Shaik in Hebrew University where he majorly focused on valance bond modelling and electronic transfer reactions. In 1996, he moved to Switzerland and did his second postdoctoral studies with Prof. Thomas Bally in University of Fibourg, Switzerland. In Switzerland he worked in Molecular modelling and theoretical and physical organic chemistry.

Career

After two postdoctoral stints, he moved to India and he has served as Assistant Professor in Pondicherry University for five years (1997 – 2002). There majorly focused on Molecular modelling and theoretical and physical organic chemistry. In 2002 he moved to CSIR – Indian Institute of Chemical Technology, Hyderabad where he served for almost two decades and made fundamental contributions in supramolecular chemistry which itself is a highly interdisciplinary areas. On 19 February 2019, he took charge as a Director in CSIR – North East Institute of Science and Technology, Jorhat, Assam and served their till 10 January 2024. Currently, he is serving as Professor at Department of Biotechnology at IIT-Hyderabad.

Scientific contributions

Sastry's group is highly interdisciplinary with diverse background that include chemistry, biology, material science, and computer science. With more than 300 research papers, which received over ~11000 citations, and an h-index of 52, he is one of the most prolific scientist in India making contributions in areas like noncovalent interactions, [6] [7] computer aided drug design, [8] [9] [10] [11] bucky bowl chemistry, [12] [13] and applications of machine learning in computational drug discovery. [14] [15] He is also interested to unravel ~5000 years of traditional knowledge with 100 years of modern science. DISHA (Development of Informatics for Societal Health Advancement) has been conceived by Dr. G.N. Sastry with the aim to leverage the activities of data driven approaches in healthcare.

In the last decade, his group is involved in developing an indigenous software, Molecular Property Diagnostic Suite (MPDS), [16] [17] [18] which aims to strengthen the computational drug discovery, and thereby working towards Aatmanirbhar Bharat. Dr. Sastry is also involved in a number of outreach programs and widely traveled across the globe and has visited over 25 countries. His stays as a visiting professor (faculty) in Japan, USA, Germany and Switzerland, besides several short visits to attend and organize meetings abroad has established a strong relationship in building international collaborations across the disciplines.

Fellowships and memberships

Prizes and honours

Leadership activities

As the Director, Dr. Sastry has shown outstanding leadership with many major programs and creating facilities contributing to the northeast region as well as nation.

Related Research Articles

The Shanti Swarup Bhatnagar Prize for Science and Technology (SSB) is a science award in India given annually by the Council of Scientific and Industrial Research (CSIR) for notable and outstanding research, applied or fundamental, in biology, chemistry, environmental science, engineering, mathematics, medicine, and physics. The prize recognizes outstanding Indian work in science and technology. It is the most coveted award in multidisciplinary science in India. The award is named after the founder Director of the Council of Scientific & Industrial Research, Shanti Swarup Bhatnagar. It was first awarded in 1958.

<span class="mw-page-title-main">Council of Scientific and Industrial Research</span> Indian scientific research and development organization

The Council of Scientific and Industrial Research is a research and development (R&D) organisation in India to promote scientific, industrial and economic growth. Headquartered in New Delhi, it was established as an autonomous body in 1942 under the aegis of the Department of Scientific and Industrial Research (DSIR), Ministry of Science and Technology, Government of India. CSIR is among the largest publicly funded R&D organisations in the world. CSIR has pioneered sustained contribution to science and technology (S&T) human resource development in India.

The Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) is a multidisciplinary research institute located at Jakkur, Bangalore, India. JNCASR was established by the Department of Science and Technology of the Government of India as a centre for advanced scientific research in India, to mark the birth centenary of Pandit Jawaharlal Nehru, the first prime minister of independent India. In 2019, JNCASR was ranked #7 among the world's top ten research institutes and universities by Nature journal in a normalised ranking of research institutes and universities with high quality output.

<span class="mw-page-title-main">Shanti Swarup Bhatnagar</span> Indian chemist

Sir Shanti Swarup Bhatnagar OBE, FNI, FASc, FRS, FRIC, FInstP was an Indian colloid chemist, academic and scientific administrator. The first director-general of the Council of Scientific and Industrial Research (CSIR), Bhatnagar is revered as the Father of Research Laboratories in India. He was also the first Chairman of the University Grants Commission (UGC).

<span class="mw-page-title-main">North East Institute of Science and Technology, Jorhat</span> It is a very amazing research centre

North East Institute of Science and Technology (NEIST) (formerly Regional Research Laboratory) is a constituent establishment of the Council of Scientific and Industrial Research (CSIR), a premier R&D organization of India, which has a chain of laboratories across the country. This laboratory was established in 1961 under the chemical science group of CSIR and originally its main aim was to develop indigenous technologies by utilizing the immense natural resources of northeastern India like Petroleum, Coal, Natural Gas, Minerals, Tea, Microbes, Aromatic and Medicinal plants.

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Goverdhan Mehta FNA, FASc, FTWAS, FRS, FRSC is an Indian researcher and scientist. From 1998-2005 he was the Director of the Indian Institute of Science (IISc). Previously from 1977-1998, Mehta was a professor of chemistry and Vice-Chancellor at the University of Hyderabad. Mehta has authored over 550 research papers.

Souvik Maiti is an Indian chemist known for his studies in the fields of biophysical chemistry and chemical biology focusing on nucleic acids, DNA and RNA. He works at the Institute of Genomics and Integrative Biology. He is also visiting scientist at National Chemical Laboratory Pune.

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Vinod Bhakuni (1962–2011) was an Indian molecular biophysicist and the head of the Molecular and Structural Biology Division of the Central Drug Research Institute (CDRI). He was the founder of the Protein Chemistry laboratory of CDRI and was known for his contributions to the study of protein folding. A recipient of the National Bioscience Award for Career Development, he was an elected fellow of the Indian Academy of Sciences, Indian National Science Academy and the National Academy of Sciences, India. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2006, for his contributions to biological sciences.

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Tavarekere Kalliah Chandrashekar is an Indian bioinorganic chemist and a former director of the National Institute for Interdisciplinary Science and Technology, a CSIR subsidiary. He was appointed the director of the National Institute of Science Education and Research, Bhubaneswar where he continues as a senior professor at the department of chemical sciences. He is known for the discovery of novel macrocyclic systems and is an elected fellow of the Indian National Science Academy, National Academy of Sciences, India and the Indian Academy of Sciences. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2001, for his contributions to chemical sciences.

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<span class="mw-page-title-main">K N Ganesh</span>

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References

  1. ↑ "G. Narahari Sastry". IIT Hyderabad. Retrieved 30 March 2024.
  2. ↑ "CSIR-NEIST, Jorhat". www.rrljorhat.res.in. Retrieved 26 March 2019.
  3. ↑ "Assam: CSIR-North East Institute of Science and Technology gets new director". Northeast Now. 19 February 2019. Retrieved 26 March 2019.
  4. ↑ Geetanath, V. (4 March 2019). "IICT scientist to head CSIR's only north east lab". The Hindu. ISSN   0971-751X . Retrieved 26 March 2019.
  5. ↑ "11 scientists selected for Shanti Swarup Bhatnagar award" ibn live, Sep 26,2011
  6. ↑ Mahadevi, A. Subha; Sastry, G. Narahari (2016). "Cooperativity in Noncovalent Interactions". Chemical Reviews. 116 (5): 2775–2825. doi:10.1021/cr500344e. PMID   26840650.
  7. ↑ Kumar, Nandan; Saha, Soumen; Sastry, G. Narahari (2021). "Towards developing a criterion to characterize non-covalent bonds: A quantum mechanical study". Physical Chemistry Chemical Physics. 23 (14): 8478–8488. Bibcode:2021PCCP...23.8478K. doi:10.1039/D0CP05689H. PMID   33876011. S2CID   233308675.
  8. ↑ Badrinarayan, Preethi; Sastry, G. Narahari (2011). "Sequence, Structure, and Active Site Analyses of p38 MAP Kinase: Exploiting DFG-out Conformation as a Strategy to Design New Type II Leads". Journal of Chemical Information and Modeling. 51 (1): 115–129. doi:10.1021/ci100340w. PMID   21141877.
  9. ↑ Badrinarayan, Preethi; Sastry, G. Narahari (2014). "Specificity Rendering "Hot-Spots" for Aurora Kinase Inhibitor Design: The Role of Non-Covalent Interactions and Conformational Transitions". PLOS ONE. 9 (12): e113773. Bibcode:2014PLoSO...9k3773B. doi: 10.1371/journal.pone.0113773 . PMC   4259475 . PMID   25485544.
  10. ↑ Choudhury, Chinmayee; Priyakumar, U. Deva; Sastry, G. Narahari (2015). "Dynamics Based Pharmacophore Models for Screening Potential Inhibitors of Mycobacterial Cyclopropane Synthase". Journal of Chemical Information and Modeling. 55 (4): 848–860. doi:10.1021/ci500737b. PMID   25751016.
  11. ↑ Madugula, Sita Sirisha; Nagamani, Selvaraman; Jamir, Esther; Priyadarsinee, Lipsa; Sastry, G. Narahari (2022). "Drug repositioning for anti-tuberculosis drugs: An in silico polypharmacology approach". Molecular Diversity. 26 (3): 1675–1695. doi:10.1007/s11030-021-10296-2. PMID   34468898. S2CID   237372892.
  12. ↑ Purushotham, Uppula; Sastry, G. Narahari (2013). "Conjugate acene fused buckybowls: Evaluating their suitability for p-type, ambipolar and n-type air stable organic semiconductors". Physical Chemistry Chemical Physics. 15 (14): 5039–5048. Bibcode:2013PCCP...15.5039P. doi:10.1039/C3CP44673E. PMID   23450210.
  13. ↑ Hussain, M. Althaf; Vijay, Dolly; Sastry, G. Narahari (2016). "Buckybowls as adsorbents for CO2, CH4, and C2H2: Binding and structural insights from computational study". Journal of Computational Chemistry. 37 (3): 366–377. doi:10.1002/jcc.24242. PMID   26519620. S2CID   461837.
  14. ↑ John, Lijo; Soujanya, Yarasi; Mahanta, Hridoy Jyoti; Narahari Sastry, G. (2022). "Chemoinformatics and Machine Learning Approaches for Identifying Antiviral Compounds". Molecular Informatics. 41 (4): e2100190. doi:10.1002/minf.202100190. PMID   34811938. S2CID   244490227.
  15. ↑ Singh, Prateek; et al. (2022). "A machine learning-based approach to determine infection status in recipients of BBV152 (Covaxin) whole-virion inactivated SARS-CoV-2 vaccine for serological surveys". Computers in Biology and Medicine. 146: 105419. doi:10.1016/j.compbiomed.2022.105419. PMC   9040372 . PMID   35483225. S2CID   245261536.
  16. ↑ Gaur, Anamika Singh; et al. (2017). "Assessing therapeutic potential of molecules: Molecular property diagnostic suite for tuberculosis MPDS TB". Journal of Chemical Sciences. 129 (5): 515–531. doi: 10.1007/s12039-017-1268-4 . S2CID   199377264.
  17. ↑ Nagamani, S.; Gaur, A. S.; Tanneeru, K.; Muneeswaran, G.; Madugula, S. S.; Consortium, Mpds; Druzhilovskiy, D.; Poroikov, V. V.; Sastry, G. N. (2017). "Molecular property diagnostic suite (MPDS): Development of disease-specific open source web portals for drug discovery". Sar and Qsar in Environmental Research. 28 (11): 913–926. Bibcode:2017SQER...28..913N. doi:10.1080/1062936X.2017.1402819. PMID   29206500. S2CID   22904128.
  18. ↑ Gaur, Anamika Singh; Nagamani, Selvaraman; Tanneeru, Karunakar; Druzhilovskiy, Dmitry; Rudik, Anastassia; Poroikov, Vladimir; Narahari Sastry, G. (2018). "Molecular property diagnostic suite for diabetes mellitus (MPDSDM): An integrated web portal for drug discovery and drug repurposing". Journal of Biomedical Informatics. 85: 114–125. doi: 10.1016/j.jbi.2018.08.003 . PMID   30092360. S2CID   51952429.
  19. ↑ "FNA". www.insaindia.res.in. Retrieved 2 July 2022.
  20. ↑ "FASc". www.ias.ac.in. Retrieved 2 July 2022.
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  22. ↑ "FBRSI". www.brsi.in. 10 July 2021. Retrieved 2 July 2022.
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  25. ↑ "J C Bose Fellowship". www.serb.gov.in. Retrieved 26 March 2019.
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  27. ↑ Organisms, objects and ocean are their work indianexpress.com [ dead link ]
  28. ↑ "Dr. G. Narahari Sastry". humboldt-foundation.de. Retrieved 7 July 2020.
  29. ↑ "Swarnajayanti Fellowship" (PDF). www.dst.gov.in. Retrieved 2 July 2022.
  30. ↑ "Archived copy". Archived from the original on 25 April 2012. Retrieved 25 October 2011.{{cite web}}: CS1 maint: archived copy as title (link)
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  32. ↑ "New flowering plant discovered in Arunachal Pradesh". NORTHEAST NOW. 5 March 2024.
  33. ↑ "SRTP". www.vigyanprasar.gov.in. Retrieved 2 July 2022.
  34. ↑ "CSIR lab to organise nationwide summer research training programme".
  35. ↑ "Drug Discovery Hackathon". www.csir.res.in. Retrieved 2 July 2022.
  36. ↑ "Drug Discovery Hackathon". www.vigyanprasar.gov.in. Retrieved 2 July 2022.
  37. ↑ "Indore: Aastha soni selected for Drug Discovery Mentorship and Training Program".
  38. ↑ "COVID-19 testing laboratory inaugurated in CSIR-NEIST, Jorhat".
  39. ↑ "A COVID-19 testing laboratory established at Jorhat campus of NEIST in Assam". The Statesman . 2 June 2020.
  40. ↑ "Assam scientist bags Shanti Swarup Bhatnagar award for pioneering work". 28 September 2021.
  41. ↑ "Infomar 2019" (PDF). Archived from the original (PDF) on 19 March 2022. Retrieved 2 July 2022.
  42. ↑ "CSIR-NEIST signs MoU with BCPL".
  43. ↑ Geetanath, V. (20 July 2021). "Genome surveillance for north east region begins". The Hindu.
  44. ↑ "Assam: Jorhat-based NEIST signs pact with National Medicinal Plants Board for setting up facilitation Centre". April 2021.
  45. ↑ "CSIR-NEIST BioNEST, Jorhat – East & Northeast Region BioNEST Cluster".
  46. ↑ "Itanagar: CSIR and CMERI set up 'centre for post harvest processing and research | Arunachal24". 20 August 2019.
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