Glutamine—pyruvate transaminase

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glutamine-pyruvate transaminase
Identifiers
EC no. 2.6.1.15
CAS no. 9030-44-8
Databases
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BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
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In enzymology, a glutamine-pyruvate transaminase (EC 2.6.1.15) is an enzyme that catalyzes the chemical reaction

L-glutamine + pyruvate 2-oxoglutaramate + L-alanine

Thus, the two substrates of this enzyme are L-glutamine and pyruvate, whereas its two products are 2-oxoglutaramate and L-alanine.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-glutamine:pyruvate aminotransferase. Other names in common use include glutaminase II, L-glutamine transaminase L, and glutamine-oxo-acid transaminase. This enzyme participates in glutamate metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1V2D, 1V2E, and 1V2F.

Related Research Articles

<span class="mw-page-title-main">Transaminase</span> Class of enzymes

Transaminases or aminotransferases are enzymes that catalyze a transamination reaction between an amino acid and an α-keto acid. They are important in the synthesis of amino acids, which form proteins.

<span class="mw-page-title-main">Amino acid synthesis</span> The set of biochemical processes by which amino acids are produced

Amino acid biosynthesis is the set of biochemical processes by which the amino acids are produced. The substrates for these processes are various compounds in the organism's diet or growth media. Not all organisms are able to synthesize all amino acids. For example, humans can synthesize 11 of the 20 standard amino acids. These 11 are called the non-essential amino acids.

The enzyme 2,2-dialkylglycine decarboxylase (pyruvate) (EC 4.1.1.64) catalyzes the chemical reaction

In enzymology, a 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase is an enzyme that catalyzes the chemical reaction

In enzymology, a 2-aminoethylphosphonate—pyruvate transaminase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">4-aminobutyrate transaminase</span> Class of enzymes

In enzymology, 4-aminobutyrate transaminase, also called GABA transaminase or 4-aminobutyrate aminotransferase, or GABA-T, is an enzyme that catalyzes the chemical reaction:

<span class="mw-page-title-main">Alanine—glyoxylate transaminase</span>

In enzymology, an alanine-glyoxylate transaminase is an enzyme that catalyzes the chemical reaction

In enzymology, an alanine-oxo-acid transaminase is an enzyme that catalyzes the chemical reaction

In enzymology, an alanine-oxomalonate transaminase is an enzyme that catalyzes the chemical reaction

In enzymology, an aminolevulinate transaminase is an enzyme that catalyzes the chemical reaction

In enzymology, an arginine-pyruvate transaminase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Beta-alanine—pyruvate transaminase</span> Enzyme

In enzymology, a beta-alanine-pyruvate transaminase is an enzyme that catalyzes the chemical reaction

In enzymology, a D-amino-acid transaminase is an enzyme that catalyzes the chemical reaction:

In enzymology, a diaminobutyrate-pyruvate transaminase is an enzyme that catalyzes the chemical reaction

In enzymology, a D-methionine—pyruvate transaminase is an enzyme that catalyzes the chemical reaction

In enzymology, a (R)-3-amino-2-methylpropionate—pyruvate transaminase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Serine—pyruvate transaminase</span>

In enzymology, a serine-pyruvate transaminase is an enzyme that catalyzes the chemical reaction

In enzymology, a valine-pyruvate transaminase is an enzyme that catalyzes the chemical reaction

Glutaminolysis (glutamine + -lysis) is a series of biochemical reactions by which the amino acid glutamine is lysed to glutamate, aspartate, CO2, pyruvate, lactate, alanine and citrate.

4-aminobutyrate---pyruvate transaminase is an enzyme with systematic name 4-aminobutanoate:pyruvate aminotransferase. This enzyme is a type of GABA transaminase, which degrades the neurotransmitter GABA. The enzyme catalyses the following chemical reaction

References