Glutamine—fructose-6-phosphate transaminase (isomerizing)

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glutamine-fructose-6-phosphate transaminase (isomerizing)
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Glutamine—fructose-6-phosphate transaminase 1, homodimer, Human
Identifiers
EC no. 2.6.1.16
CAS no. 9030-45-9
Alt. names
  • hexosephosphate aminotransferase
  • glucosamine-6-phosphate isomerase (glutamine-forming)
  • glutamine-fructose-6-phosphate transaminase (isomerizing)
  • D-fructose-6-phosphate amidotransferase
  • glucosaminephosphate isomerase
  • glucosamine 6-phosphate synthase
  • GlcN6P synthase
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, a glutamine-fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) is an enzyme that catalyzes the chemical reaction

L-glutamine + D-fructose 6-phosphate L-glutamate + D-glucosamine 6-phosphate

Thus, the two substrates of this enzyme are L-glutamine and D-fructose 6-phosphate, whereas its two products are L-glutamate and D-glucosamine 6-phosphate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-glutamine:D-fructose-6-phosphate isomerase (deaminating). This enzyme participates in glutamate metabolism and aminosugars metabolism.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1JXA, 1MOQ, 1MOR, 1MOS, 1XFF, 1XFG, 2BPL, 2J6H, 2POC, 2PUT, 2PUV, and 2PUW.

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References