HAAO

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3-hydroxyanthranilic acid dioxygenase
Identifiers
Aliases 3hydroanth_dOaseIPR0103293-hydroxyanthranilate 3,4-dioxygenase3-hydroxyanthranilate oxygenase3-hydroxyanthranilic oxygenase3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)3-hydroxyanthranilic acid oxygenase
External IDs GeneCards:
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human
3-hydroxyanthranilate 3,4-dioxygenase
5tk5.jpg
3-hydroxyanthranilate 3,4-dioxygenase monomer, Human
Identifiers
EC no. 1.13.11.6
CAS no. 9029-50-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6) is an enzyme encoded by the HAAO gene that catalyzes the chemical reaction

3-hydroxyanthranilate + O2 2-amino-3-carboxymuconate semialdehyde

Thus, the two substrates of this enzyme are 3-hydroxyanthranilate and O2, whereas its product is 2-amino-3-carboxymuconate semialdehyde.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2.

The systematic name of this enzyme class is 3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing). Other names in common use include 3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid oxygenase, 3-hydroxyanthranilic oxygenase, 3-hydroxyanthranilic acid oxidase and 3HAO. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1YFU, 1YFW, 1YFX, 1YFY, 1ZVF, and 2QNK.h

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References

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