HPSE2

HPSE2
Identifiers
Aliases	HPSE2 , HPA2, HPR2, UFS, UFS1, heparanase 2 (inactive)
External IDs	OMIM: 613469; MGI: 2685814; HomoloGene: 19680; GeneCards: HPSE2; OMA:HPSE2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q24.2 Start 98,457,077 bp [1] End 99,235,862 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 C3 Start 42,774,978 bp [2] End 43,376,794 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon canal of the cervix gastric mucosa ectocervix popliteal artery tibial arteries hypothalamus caudate nucleus putamen C1 segment Top expressed in genital tubercle pineal gland spermatid zygote migratory enteric neural crest cell hand urinary bladder lobe of prostate lip Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparan sulfate proteoglycan binding heparanase activity hydrolase activity, acting on glycosyl bonds Cellular component extracellular region plasma membrane intracellular anatomical structure membrane extracellular matrix Biological process glycosaminoglycan catabolic process positive regulation of cell population proliferation extracellular matrix organization biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60495 545291 Ensembl ENSG00000172987 ENSMUSG00000074852 UniProt Q8WWQ2 B2RY83 RefSeq (mRNA) NM_001166244 NM_001166245 NM_001166246 NM_021828 NM_001081257 RefSeq (protein) NP_001159716 NP_001159717 NP_001159718 NP_068600 NP_001074726 Location (UCSC) Chr 10: 98.46 – 99.24 Mb Chr 19: 42.77 – 43.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Heparanase-2 is an enzyme that in humans is encoded by the HPSE2 gene. ^{[5] [6]}

It may be associated with urofacial syndrome. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000172987 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074852 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McKenzie E, Tyson K, Stamps A, Smith P, Turner P, Barry R, Hircock M, Patel S, Barry E, Stubberfield C, Terrett J, Page M (Oct 2000). "Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member". Biochem Biophys Res Commun. 276 (3): 1170–7. doi:10.1006/bbrc.2000.3586. PMID   11027606.
6. "Entrez Gene: HPSE2 heparanase 2".
7. Daly SB, Urquhart JE, Hilton E, et al. (June 2010). "Mutations in HPSE2 Cause Urofacial Syndrome". Am J Hum Genet. 86 (6): 963–969. doi:10.1016/j.ajhg.2010.05.006. PMC   3032078 . PMID   20560210.

Further reading

• D'Souza SS, Fazleabas AT, Banerjee P, et al. (2008). "Decidual heparanase activity is increased during pregnancy in the baboon (Papio anubis) and in in vitro decidualization of human stromal cells". Biol. Reprod. 78 (2): 316–23. doi: 10.1095/biolreprod.107.063891 . PMID   17989358. S2CID   32383560.
• Bar-Sela G, Kaplan-Cohen V, Ilan N, et al. (2006). "Heparanase expression in nasopharyngeal carcinoma inversely correlates with patient survival". Histopathology. 49 (2): 188–93. doi:10.1111/j.1365-2559.2006.02469.x. PMID   16879396. S2CID   46173868.
• Beckhove P, Helmke BM, Ziouta Y, et al. (2005). "Heparanase expression at the invasion front of human head and neck cancers and correlation with poor prognosis". Clin. Cancer Res. 11 (8): 2899–906. doi:10.1158/1078-0432.CCR-04-0664. PMID   15837740. S2CID   22489633.
• Ogishima T, Shiina H, Breault JE, et al. (2005). "Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer". Clin. Cancer Res. 11 (3): 1028–36. doi: 10.1158/1078-0432.1028.11.3 . PMID   15709168.
• Wang Z, Xu H, Jiang L, et al. (2005). "Positive association of heparanase expression with tumor invasion and lymphatic metastasis in gastric carcinoma". Mod. Pathol. 18 (2): 205–11. doi: 10.1038/modpathol.3800282 . PMID   15475937.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.