LI-COR Biosciences

Last updated
LI-COR, Inc.
TypePrivate
Industry Research / Design / Manufacturing
Founded1971
Headquarters Lincoln, NE, U.S.A.
Key people
William Biggs, Founder, Thomas Reslewic, CEO
ProductsScientific Instruments, Measurement Systems and Software for Biological and Environmental Research
Website LI-COR website

LI-COR Biosciences is an international biotech company which designs, manufactures, and markets instruments, measurement systems, and software for biological and environmental research, and develops relevant measurement methodologies and techniques. [1]

Contents

Origins and history

LI-COR Biosciences was a privately held company based in Lincoln, Nebraska, until its acquisition by Battery Ventures in 2021. [2] It was founded in 1971 under the name Lambda Instruments Corporation. The name was shortened to LI-COR, Inc., in 1978.

Products and Applications

Biotechnology

The LI-7500 (right) is used to measure CO2 and H2O concentrations. Eddy Covariance IRGA Sonic.jpg
The LI-7500 (right) is used to measure CO2 and H2O concentrations.

LI-COR biotechnology instruments, software and reagents, which are based on near-infrared fluorescent and chemiluminescent detection, are used in a large variety of assays, such as western blot assays and cell-based assays, as well as in vivo imaging and DNA analysis. Primary applications include cancer research, [3] drug discovery, [4] genomics research, [5] neuroscience, cell biology, and education.

Environmental

LI-COR environmental instruments and software are used for photosynthesis research, [6] greenhouse gas monitoring, [7] greenhouse gas flux measurements, [8] and soil respiration measurements. [9] [10] LI-COR also manufactures light sensors, leaf area meters, and plant canopy analyzers, [11] all of which are used to make fundamental measurements in disciplines including plant physiology, climate change, agronomy (forestry and agriculture), and other areas of the natural sciences.

Scientific contributions and recognition

LI-COR automated DNA sequencers were the primary systems used by Genoscope, the French National Sequencing Center to sequence chromosome 14 of the Human Genome Project.

Researchers affiliated with micrometeorological networks around the world use LI-COR carbon dioxide and water vapor analyzers to assess ecosystem greenhouse gas exchange with the eddy covariance technique. These networks include FluxNet and regional networks such as AmeriFlux, ICOS and AsiaFlux.

In 2010, the editors of R&D Magazine selected the LI-7700 Open Path CH4 Analyzer for an R&D 100 Award. [12]

In 2013, the historic benchmark of increase in CO2 concentrations at 400 ppm was reported by the National Oceanic and Atmospheric Administration using LI-7000 Closed Path CO2/H2O gas analyzer. [13]

The LI-6400/6400XT Portable Photosynthesis System is the most frequently cited photosynthesis system in peer-reviewed scientific literature. [14]

See also

Related Research Articles

<span class="mw-page-title-main">Photosynthesis</span> Biological process to convert light into chemical energy

Photosynthesis is a biological process used by many cellular organisms to convert light energy into chemical energy, which is stored in organic compounds that can later be metabolized through cellular respiration to fuel the organism's activities. The term usually refers to oxygenic photosynthesis, where oxygen is produced as a byproduct, and some of the chemical energy produced is stored in carbohydrate molecules such as sugars, starch and cellulose, which are synthesized from endergonic reaction of carbon dioxide with water. Most plants, algae and cyanobacteria perform photosynthesis; such organisms are called photoautotrophs. Photosynthesis is largely responsible for producing and maintaining the oxygen content of the Earth's atmosphere, and supplies most of the biological energy necessary for complex life on Earth.

<span class="mw-page-title-main">Dissolved inorganic carbon</span> Sum of inorganic carbon species in a solution

Dissolved inorganic carbon (DIC) is the sum of the aqueous species of inorganic carbon in a solution. Carbon compounds can be distinguished as either organic or inorganic, and as dissolved or particulate, depending on their composition. Organic carbon forms the backbone of key component of organic compounds such as – proteins, lipids, carbohydrates, and nucleic acids.

Isoflavones are substituted derivatives of isoflavone, a type of naturally occurring isoflavonoids, many of which act as phytoestrogens in mammals. Isoflavones are produced almost exclusively by the members of the bean family, Fabaceae (Leguminosae).

<span class="mw-page-title-main">Eddy covariance</span> Atmospheric measurement technique

The eddy covariance is a key atmospheric measurement technique to measure and calculate vertical turbulent fluxes within atmospheric boundary layers. The method analyses high-frequency wind and scalar atmospheric data series, gas, energy, and momentum, which yields values of fluxes of these properties. It is a statistical method used in meteorology and other applications to determine exchange rates of trace gases over natural ecosystems and agricultural fields, and to quantify gas emissions rates from other land and water areas. It is frequently used to estimate momentum, heat, water vapour, carbon dioxide and methane fluxes.

<span class="mw-page-title-main">Genistein</span> Chemical compound

Genistein (C15H10O5) is a naturally occurring compound that structurally belongs to a class of compounds known as isoflavones. It is described as an angiogenesis inhibitor and a phytoestrogen.

<span class="mw-page-title-main">Daidzein</span> Chemical compound

Daidzein is a naturally occurring compound found exclusively in soybeans and other legumes and structurally belongs to a class of compounds known as isoflavones. Daidzein and other isoflavones are produced in plants through the phenylpropanoid pathway of secondary metabolism and are used as signal carriers, and defense responses to pathogenic attacks. In humans, recent research has shown the viability of using daidzein in medicine for menopausal relief, osteoporosis, blood cholesterol, and lowering the risk of some hormone-related cancers, and heart disease. Despite the known health benefits, the use of both puerarin and daidzein is limited by their poor bioavailability and low water solubility.

<span class="mw-page-title-main">Soil respiration</span> Chemical process produced by soil and the organisms within it

Soil respiration refers to the production of carbon dioxide when soil organisms respire. This includes respiration of plant roots, the rhizosphere, microbes and fauna.

Soil gases are the gases found in the air space between soil components. The spaces between the solid soil particles, if they do not contain water, are filled with air. The primary soil gases are nitrogen, carbon dioxide and oxygen. Oxygen is critical because it allows for respiration of both plant roots and soil organisms. Other natural soil gases include nitric oxide, nitrous oxide, methane, and ammonia. Some environmental contaminants below ground produce gas which diffuses through the soil such as from landfill wastes, mining activities, and contamination by petroleum hydrocarbons which produce volatile organic compounds.

<span class="mw-page-title-main">Ecosystem respiration</span> Oxidation of organic compounds within an ecosystem

Ecosystem respiration is the sum of all respiration occurring by the living organisms in a specific ecosystem. The two main processes that contribute to ecosystem respiration are photosynthesis and cellular respiration. Photosynthesis uses carbon-dioxide and water, in the presence of sunlight to produce glucose and oxygen whereas cellular respiration uses glucose and oxygen to produce carbon-dioxide, water, and energy. The coordination of inputs and outputs of these two processes creates a completely interconnected system, constituting the underlying functioning of the ecosystems overall respiration.

<span class="mw-page-title-main">Genistin</span> Chemical compound

Genistin is an isoflavone found in a number of dietary plants like soy and kudzu. It was first isolated in 1931 from the 90% methanol extract of a soybean meal, when it was found that hydrolysis with hydrochloric acid produced 1 mole each of genistein and glucose. Chemically it is the 7-O-beta-D-glucoside form of genistein and is the predominant form of the isoflavone naturally occurring in plants. In fact, studies in the 1970s revealed that 99% of the isoflavonoid compounds in soy are present as their glucosides. The glucosides are converted by digestive enzymes in the digestive system to exert their biological effects. Genistin is also converted to a more familiar genistein, thus, the biological activities including antiatherosclerotic, estrogenic and anticancer effects are analogous.

Geniom RT Analyzer is an instrument used in molecular biology for diagnostic testing. The Geniom RT Analyzer utilizes the dynamic nature of tissue microRNA levels as a biomarker for disease progression. The Geniom analyzer incorporates microfluidic and biochip microarray technology in order to quantify microRNAs via a Microfluidic Primer Extension Assay (MPEA) technique.

<span class="mw-page-title-main">Greenhouse gas monitoring</span> Measurement of greenhouse gas emissions and levels

Greenhouse gas monitoring is the direct measurement of greenhouse gas emissions and levels. There are several different methods of measuring carbon dioxide concentrations in the atmosphere, including infrared analyzing and manometry. Methane and nitrous oxide are measured by other instruments. Greenhouse gases are measured from space such as by the Orbiting Carbon Observatory and networks of ground stations such as the Integrated Carbon Observation System.

<span class="mw-page-title-main">Photosynthesis system</span>

Photosynthesis systems are electronic scientific instruments designed for non-destructive measurement of photosynthetic rates in the field. Photosynthesis systems are commonly used in agronomic and environmental research, as well as studies of the global carbon cycle.

<span class="mw-page-title-main">Plant stress measurement</span>

Plant stress measurement is the quantification of environmental effects on plant health. When plants are subjected to less than ideal growing conditions, they are considered to be under stress. Stress factors can affect growth, survival and crop yields. Plant stress research looks at the response of plants to limitations and excesses of the main abiotic factors, and of other stress factors that are important in particular situations. Plant stress measurement usually focuses on taking measurements from living plants. It can involve visual assessments of plant vitality, however, more recently the focus has moved to the use of instruments and protocols that reveal the response of particular processes within the plant

Seahorse Bioscience is a private company that develops and manufactures cellular bioenergetics analytical instruments. Seahorse also manufactures consumable labware products, and consumables for measuring cell metabolism. The company was formerly known as Thermogenic Imaging. Recognized for developing novel, leading-edge cellular bioenergetic technologies, the company is best known for developing the XF Extracellular Flux Analyzer.

In chemistry, a sample's oxygen–argon ratio (or oxygen/argon ratio) is a comparison between the concentrations of oxygen (O2) and the noble gas argon (Ar), either in air or dissolved in a liquid such as seawater. The two gases have very similar physical properties such as solubility and diffusivity, as well as a similar temperature dependence, making them easy to compare.

Thomas D. Sharkey is a plant biochemist who studies gas exchange between plants and the atmosphere. His research has covered (1) carbon metabolism of photosynthesis from carbon dioxide uptake to carbon export from the Calvin-Benson Cycle, (2) isoprene emission from plants, and (3) abiotic stress tolerance. Four guiding questions are: (1) how leaf photosynthesis affects plant yield, (2) does some carbon fixation follow an oxidative pathway that reduces sugar output but stabilizes photosynthesis, (3) why plants make isoprene, and (4) how plants cope with high temperature.

<span class="mw-page-title-main">George Burba</span> American bio-atmospheric scientist

George Burba is an American bio-atmospheric scientist, author, and inventor.

<span class="mw-page-title-main">Non-invasive micro-test technology</span>

Non-invasive micro-test technology (NMT) is a scientific research technology used for measuring physiological events of intact biological samples. NMT is used for research in many biological areas such as gene function, plant physiology, biomedical research, and environmental science.

Mariah Suzanne Carbone is an American geophysicist who is a professor of Geosciences at the Center for ecosystem science and society, Northern Arizona University. She studies terrestrial ecosystems and how they respond to environmental change.

References

  1. "Lincoln-based Li-Cor keeps evolving after 45 years as a leader in biosciences". Omaha World Herald. 2016-01-08. Retrieved 2016-09-07.
  2. "Battery Ventures Acquires Analytical-Instrumentation Pioneer LI-COR Biosciences". Business Wire. 2021-12-08. Retrieved 2022-03-05.
  3. Li, Yiwei; Ahmed, F.; Ali, S.; Philip, P. A.; Kucuk, O.; Sarkar, F. H. (2005). "Inactivation of nuclear factor kB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells". Cancer Research. 65 (15): 6934–6942. doi:10.1158/0008-5472.can-04-4604. PMID   16061678.
  4. Li, Yiwei; Ellis, K. L.; Ali, S.; El-Rayes, B.; Nedeljkovic-Kurepa, A.; Kucuk, O.; Philip, P. A.; Sarkar, F. H. (2004). "Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein, a natural inhibitor of NF-[kappa]B in BxPC-3 pancreatic cancer cell line". Pancreas. 28 (4): 90–95. doi:10.1097/00006676-200405000-00020. PMID   15097869. S2CID   12237431.
  5. Liu, Z.; Attila, K.; Ping, L.; Dongfeng, C.; Dunham, R. (2003). "An AFLP-based genetic linkage map of channel catfish (Ictalurus punctatus) construction by using an interspecific hybrid resource family". Genetics. 165 (2): 689–694. doi:10.1093/genetics/165.2.687. PMC   1462775 . PMID   14573480.
  6. Bernacchi, C. J.; Singsaas, E. L.; Pimental, C.; Portis, Jr.; Long, S. P. (2004). "Improved temperature response functions for models of Rubisco-limited photosynthesis". Plant, Cell & Environment. 24 (2): 253–259. doi:10.1111/j.1365-3040.2001.00668.x.
  7. Luo, Y.; Wan, S.; Hui, D.; Wallace, L. L. (2001). "Acclimatization of soil respiration to warming in a tall grass prairie". Nature. 413 (6856): 622–625. Bibcode:2001Natur.413..622L. doi:10.1038/35098065. PMID   11675783. S2CID   4427793.
  8. Ohkubo, S.; Kosugi, Y.; Takahashi, S.; Mitani, T.; Tani, M. (2006). "Comparison of the eddy covariance and automated closed chamber methods for evaluating nocturnal CO2 exchange in Japanese cypress forest". Agricultural and Forest Meteorology. 142: 50–65. doi:10.1016/j.agrformet.2006.11.004.
  9. Liu, W.; Zhang, Z.; Wan, S. (2008). "Predominant role of water in regulating soil and microbial respiration and their responses to climate change in a semiarid grassland". Global Change Biology. 15: 184–195. doi:10.1111/j.1365-2486.2008.01728.x. S2CID   86013088.
  10. Vargas, R.; Allen, M. F. (2008). "Environmental controls and the influence of vegetation type, fine roots and rhizomorphs on diel and seasonal variation in soil respiration" (PDF). New Phytologist. 179 (2): 460–471. doi: 10.1111/j.1469-8137.2008.02481.x . PMID   19086292.
  11. Welles, J. M.; Cohen, S. (1996). "Canopy structure measurement by gap fraction analysis using commercial instrumentation". Journal of Experimental Botany. 47 (9): 1335–1342. doi: 10.1093/jxb/47.9.1335 .
  12. "Keeping tabs on methane | R&D; Mag". Archived from the original on 2011-01-06. Retrieved 2010-12-23.
  13. "LI-COR instruments established historic climate news". Lincoln Journal Star. 2013-05-16. Retrieved 2016-09-07.
  14. "Physiological and Genetics Section Announcement". Botany.org. 2007-11-15. Retrieved 2016-09-07.