![]() | This article needs to be updated. The reason given is: no files for 2006 are listed at the cited source, but files for 2013 are there; NLM releases this information annually.(February 2020) |
The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM).
This list covers DNA-binding proteins. For other protein-related codes, see List of MeSH codes (D12.776).
Codes before these are found at List of MeSH codes (D12.776) § MeSH D12.776.256.920. Codes following these are found at List of MeSH codes (D12.776) § MeSH D12.776.275. For other MeSH codes, see List of MeSH codes.
The source for this content is the set of 2006 MeSH Trees from the NLM.
The list continues at List of MeSH codes (D12.776) § MeSH D12.776.275.
Sterol regulatory element-binding proteins (SREBPs) are transcription factors that bind to the sterol regulatory element DNA sequence TCACNCCAC. Mammalian SREBPs are encoded by the genes SREBF1 and SREBF2. SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors. Unactivated SREBPs are attached to the nuclear envelope and endoplasmic reticulum membranes. In cells with low levels of sterols, SREBPs are cleaved to a water-soluble N-terminal domain that is translocated to the nucleus. These activated SREBPs then bind to specific sterol regulatory element DNA sequences, thus upregulating the synthesis of enzymes involved in sterol biosynthesis. Sterols in turn inhibit the cleavage of SREBPs and therefore synthesis of additional sterols is reduced through a negative feed back loop.
CCAAT-enhancer-binding proteins is a family of transcription factors composed of six members, named from C/EBPα to C/EBPζ. They promote the expression of certain genes through interaction with their promoters. Once bound to DNA, C/EBPs can recruit so-called co-activators that in turn can open up chromatin structure or recruit basal transcription factors.
Sterol regulatory element-binding protein cleavage-activating protein, also known as SREBP cleavage-activating protein or SCAP, is a protein that in humans is encoded by the SCAP gene.
Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene.
Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene.