Transcription factor Sp2 is a protein that in humans is encoded by the SP2 gene. [5] [6] [7]
Transcription factor Sp2 is a protein that in humans is encoded by the SP2 gene. [5] [6] [7]
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [7]
Sp2 transcription factor has been shown to interact with E2F1. [8]
Transcription factor Sp1, also known as specificity protein 1* is a protein that in humans is encoded by the SP1 gene.
The vitamin D receptor (VDR also known as the calcitriol receptor) is a member of the nuclear receptor family of transcription factors. Calcitriol (the active form of vitamin D, 1,25-(OH)2vitamin D3) binds to VDR, which then forms a heterodimer with the retinoid-X receptor. The VDR heterodimer then enters the nucleus and binds to Vitamin D responsive elements (VDRE) in genomic DNA. VDR binding results in expression or transrepression of many specific gene products. VDR is also involved in microRNA-directed post transcriptional mechanisms. In humans, the vitamin D receptor is encoded by the VDR gene located on chromosome 12q13.11.
Methyl-CpG-binding domain protein 1 is a protein that in humans is encoded by the MBD1 gene. The protein encoded by MBD1 binds to methylated sequences in DNA, and thereby influences transcription. It binds to a variety of methylated sequences, and appears to mediate repression of gene expression. It has been shown to play a role in chromatin modification through interaction with the histone H3K9 methyltransferase SETDB1. H3K9me3 is a repressive modification.
Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.
POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.
Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene.
Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.
Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene.
Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene.
Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.
Sp3 transcription factor, also known as SP3, refers to both a protein and the gene it is encoded by.
Serum response factor, also known as SRF, is a transcription factor protein.
Transcription factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene.
MHC class II regulatory factor RFX1 is a protein that, in humans, is encoded by the RFX1 gene located on the short arm of chromosome 19.
Transcription factor Sp4 is a protein that in humans is encoded by the SP4 gene.
Krueppel-like factor 11 is a protein that in humans is encoded by the KLF11 gene.
Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene.
Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.
E2F-associated phosphoprotein is a protein that in humans is encoded by the EAPP gene.
Krueppel-like factor 9 is a protein that in humans is encoded by the KLF9 gene. Previously known as Basic Transcription Element Binding Protein 1, Klf9 is part of the Sp1 C2H2-type zinc finger family of transcription factors. Several previous studies showed Klf9-related regulation of animal development, including cell differentiation of B cells, keratinocytes, and neurons. Klf9 is also a key transcriptional regulator for uterine endometrial cell proliferation, adhesion, and differentiation, all factors that are essential during the process of pregnancy and are turned off during tumorigenesis.
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