| Name | Rank | Term | Nominated by | Appointed by | Accredited to |
|---|
| The consul general and chargé d'affaires in Montevideo (1845–1855) |
| Jacinto Albístur [ es ] [a] | Minister | 1855–1859 [2] | Claudio Antón de Luzuriaga | Isabella II | |
| Carlos Creus y Camps, a.i. [a] | Chargé d'affaires | 1859–1864 [3] | Saturnino Calderón Collantes |
| Minister | 1864–1865 [4] | Joaquín Francisco Pacheco |
| Pedro Sorela y Maury | Minister | 1865–1869 [5] | | Rufino de Elizalde |
| Carlos Antonio de España | Chargé d'affaires | 1869–1871 [6] | The Viscount of Barrantes | |
| Norberto Ballesteros | Chargé d'affaires | 1871–1873 [7] | | Amadeo I | Carlos Tejedor |
| José Alvarez Peralta | Minister | 1873–1874 [8] | Emilio Castelar | Estanislao Figueras |
| Norberto Ballesteros | Chargé d'affaires | 1874–1875 [9] | Augusto Ulloa y Castañón | The Duke of the Tower |
| Justo Pérez Ruano | Chargé d'affaires | 1875–1879 | | Alfonso XII | |
| Francisco Otin y Messía | Chargé d'affaires | 1879–1882 |
| Juan Durán y Cuervo | Chargé d'affaires | 1882–1883 [10] | The Marquess of Vega de Armijo |
| Minister | 1883–1888 |
| Emilio de Ojeda y Perpiñán [ es ] | Minister | 1888 [11] | Alfonso XIII |
| Salvador López Guijarro [ es ] | Minister | 1888–1889 | |
| Juan Durán y Cuervo | Minister | 1889–1898 | Francisco Silvela |
Julio de Arellano y Arróspide, Marquess of Casa Calvo | Minister | 1898–1904 [12] | The Duke of Almodóvar del Río |
| Ramiro Gil de Uribarri Ossorio | Minister | 1904–1907 | |
| Luis de la Barrera y Riera | Minister | 1907–1910 [13] | Juan Pérez-Caballero y Ferrer |
Pedro Careaga de la Quintana, Count of Cadagua | Minister | 1910 [14] |
| Pablo Soler y Guardiola | Minister | 1910–1917 [15] | The Marquess of Alhucemas |
| Ambassador | 1917–1920 [16] | Juan Alvarado y del Saz | Hipólito Yrigoyen |
Eugenio Ferraz y Alcalá-Galiano, Marquess of Amposta | Ambassador | 1920–1926 [17] | The Duke of Ripalda |
| Emilio de Palacios y Fau | Ambassador | 1926 [18] | The Viscount of Santa Clara de Avedillo | Marcelo Torcuato de Alvear |
| Antonio de Zayas y Beaumont, Duke of Amalfi | Ambassador | 1926–1927 [19] |
Ramiro de Maeztu, Count of Maeztu | Ambassador | 1927–1930 [20] | The Marquess of Estella |
| Alfonso Danvila y Burguero | Ambassador | 1930–1931 [21] | The Count of Xauen | José Félix Uriburu |
| 1931–1936 [22] | Alejandro Lerroux | Manuel Azaña |
| Enrique Díez Canedo | Ambassador | 1936–1937 [23] | Augusto Barcia Trelles | Diego Martínez Barrio | Agustín Pedro Justo |
| Manuel Blasco Garzón [ es ] (acting) | Consul General | 1937–1938 | |
| Angel Ossorio y Gallardo | Ambassador | 1938–1939 [24] | Julio Álvarez del Vayo | Manuel Azaña | Roberto Marcelino Ortiz |
| Juan Pablo de Lojendio Irure [b] | Chargé d'affaires | 1939–1940 | | Francisco Franco |
Antonio Magaz, Marquess of Magaz | Ambassador | 1940–1943 [25] | Juan Luis Beigbeder |
José Muñoz Vargas, Count of Bulnes | Ambassador | 1943–1947 [26] | Francisco Gómez-Jordana Sousa | Pedro Pablo Ramírez |
José María de Areilza, Count of Motrico | Ambassador | 1947–1950 [27] | Alberto Martín-Artajo | Juan Perón |
| Emilio de Navasqüés [ es ] | Ambassador | 1950–1951 [28] |
| Manuel Aznar Zubigaray | Ambassador | 1951–1955 [29] |
| José María Alfaro Polanco [ es ] | Ambassador | 1955–1971 [30] |
| José Sebastián de Erice y O'Shea [ es ] | Ambassador | 1971–1973 [31] | Gregorio López-Bravo | Alejandro Agustín Lanusse |
| Luis García de Llera y Rodríguez [ es ] | Ambassador | 1973–1974 [32] |
Gregorio Marañón Moya [ es ], Marquess of Marañón | Ambassador | 1974–1976 [33] | Laureano López Rodó | Juan Perón |
| Enrique Pérez Hernández y Moreno [ es ] | Ambassador | 1976–1982 [34] | The Marquess of Oreja | Juan Carlos I | Jorge Rafael Videla |
Manuel Alabart Miranda, Marquess of Busianos | Ambassador | 1982–1983 [35] | José Pedro Pérez-Llorca | Leopoldo Galtieri |
| José Luis Messía [ es ] | Ambassador | 1983–1986 [36] | Fernando Morán | Reynaldo Bignone |
| Raimundo Bassols | Ambassador | 1986–1991 [37] | Francisco Fernández Ordóñez | Raúl Alfonsín |
| Rafael Pastor Ridruejo [ es ] | Ambassador | 1991–1994 [38] | Carlos Menem |
| Nicolás Martínez-Fresno y Pavía | Ambassador | 1994–1996 [39] | Javier Solana |
| Carlos Carderera Soler | Ambassador | 1996–2000 [40] | Abel Matutes |
| Manuel Alabart [ es ] | Ambassador | 2000–2004 [41] | Josep Piqué | Fernando de la Rúa |
| Carmelo Angulo Barturen [ es ] | Ambassador | 2004–2006 [42] | Miguel Ángel Moratinos | Néstor Kirchner |
| Rafael Estrella [ es ] | Ambassador | 2006–2012 [43] |
| Román Oyarzun Marchesi [ es ] | Ambassador | 2012–2013 [44] | José Manuel García-Margallo | Cristina Fernández de Kirchner |
| Estanislao de Grandes | Ambassador | 2013–2017 [45] |
| Francisco Javier Sandomingo [ es ] | Ambassador | 2017–2022 [46] | Alfonso Dastis | Felipe VI | Mauricio Macri |
| María Jesús Alonso Jiménez [ es ] | Ambassador | 2022–2024 [47] | José Manuel Albares | Alberto Fernández |
| Joaquín María de Arístegui Laborde [ es ] | Ambassador | 2024–pres. [48] | Javier Milei |