List of investigational acne drugs

Last updated

This is a list of investigational acne drugs, or drugs that are currently under development for clinical use in the treatment of acne but are not yet approved.

Contents

Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. The format of list items is "Name (Synonyms) – Mechanism of Action [Reference]".

This list was last comprehensively updated in September 2025. It is likely to become outdated with time.

Under development

Phase 3

Phase 2/3

Phase 2

Phase 1/2

Phase 1

Preclinical

Research

Not under development

No development reported

Discontinued

Not under development

Clinically used drugs

Approved drugs

Single-drug formulations

  • Adapalene (CD-271; Differin) – retinoid (retinoic acid receptor agonist) [90]
  • Azelaic acid (BAY39-6251; Finacea; Skinoren) – undefined mechanism of action [91]
  • Benzoyl peroxide (Bepio; M6050; M605101) – undefined mechanism of action [92]
  • Clascoterone (Breezula; Winlevi; CB-03-01; cortexolone 17α-propionate) – antiandrogen (androgen receptor antagonist) [93]
  • Clindamycin (ResiDerm A; Zindaclin) – lincosamide antibiotic [94]
  • Dapsone topical (Aczone; Atrisone) – sulfone antibiotic [95]
  • Doxycycline hyclate (Acticlate; Monodox; AQ101) – tetracycline antibiotic [96]
  • Isotretinoin (Absorica; Accutane; CIP-isotretinoin; Epuris; Lisacne-CIP) – retinoid (retinoic acid receptor agonist) [97]
  • Minocycline (DFD-10; DFD-29; Emrosi; Minolira) – tetracycline antibiotic [98]
  • Minocycline foam (Amzeeq; FMX-102; FMX-103; FMX-101; FXFM-244; Zilxi) – tetracycline antibiotic [99]
  • Nadifloxacin topical – fluoroquinolone antibiotic [100]
  • Ozenoxacin (Dubine; GF-001001-00; M-5120; M-512101; M-512102; Ozadub; Ozanex; T-3912; Xepi; Zebiax) – quinolone antibiotic [101]
  • Sarecycline (Seysara; P-0005672; WC-3035) – narrow-spectrum tetracycline antibiotic [102]
  • Solubilised benzoyl peroxide (CLENZIderm M.D.; SoluCLENZ Rx Gel) – undefined mechanism of action [103]
  • Tazarotene topical (AGN-190299; Avage; Fabior; Suretin; Tazorac; Zorac) – retinoid (retinoic acid receptor agonist) [104]
  • Tretinoin (Acnisdin Retinoico; All-trans retinoic acid; Arotinoid; Avita; Dermojuventus; Loderm Retinoico; NSC 122758; Retinoic acid; Retirides; Vesanoid; Vitamin A acid; Vitamin-A Acid; Vitanol) – retinoid (retinoic acid receptor agonist) [105]
  • Tretinoin lotion (Altreno; IDP-121) – retinoid (retinoic acid receptor agonist) [106]
  • Trifarotene (Aklief; CD-5789) – retinoid acid receptor gamma (RAR-γ) agonist [107]

Combination formulations

Off-label drugs

See also

References

  1. "Benzoyl peroxide/Tretinoin - Bausch Health Companies - AdisInsight".
  2. "Berdazimer sodium - SB 204 - Ligand Pharmaceuticals - AdisInsight".
  3. "Denifanstat - Sagimet Biosciences - AdisInsight".
  4. "GED 0507-34-Levo - AdisInsight".
  5. "B 244 - AdisInsight".
  6. "Acetylcysteine lysinate - Laboratoires SMB - AdisInsight".
  7. "Aminolevulinic acid - Biofrontera - AdisInsight".
  8. "Cannabidiol - Botanix Pharmaceuticals - AdisInsight".
  9. "ASCJ 9 - AdisInsight".
  10. "Imsidolimab - AnaptysBio - AdisInsight".
  11. "Ivermectin topical - Galderma - AdisInsight".
  12. "LYS 006 - AdisInsight".
  13. "Methyl aminolevulinate - Galderma - AdisInsight".
  14. "NAI Acne - NAICONS - AdisInsight".
  15. "Omiganan - Cutanea Life Sciences - AdisInsight".
  16. "Pyrilutamide - Suzhou Kintor Pharmaceuticals - AdisInsight".
  17. "Tretinoin topical - Avecho Biotechnology - AdisInsight".
  18. "VB 1953 - AdisInsight".
  19. "Aminolevulinic acid - Shanghai Fudan-Zhangjiang Bio-Pharmaceutical - AdisInsight".
  20. "SP 0268 - AdisInsight".
  21. "AMTX 100 - AdisInsight".
  22. "ASC 60 - AdisInsight".
  23. "Trifarotene - Taro Pharmaceuticals - AdisInsight".
  24. "Acne vaccine - Immorna - AdisInsight".
  25. "ADA 308 - Aranda Pharma - AdisInsight".
  26. "Research programme: Acne vulgaris therapeutics - Attillaps Pharmaceuticals - AdisInsight".
  27. "Topical acne vulgaris therapeutic - Eluciderm - AdisInsight".
  28. "Adapalene/Minocycline - Journey Medical Corporation - AdisInsight".
  29. "Auriclosene - NovaBay Pharmaceuticals - AdisInsight".
  30. "Bermekimab - Janssen Biotech - AdisInsight".
  31. "BOS 356 - AdisInsight".
  32. "Brilacidin - Alfasigma/Innovation Pharmaceuticals - AdisInsight".
  33. "Carbamide peroxide topical - AdisInsight".
  34. "CJM 112 - AdisInsight".
  35. "Clindamycin/Tretinoin - Dr. Reddys Laboratories - AdisInsight".
  36. "Clindamycin/Tretinoin - Verisfield - AdisInsight".
  37. "DMT 200 - AdisInsight".
  38. "Estradiol valerate/Dienogest - Bayer HealthCare Pharmaceutials - AdisInsight".
  39. "Ethinylestradiol/Chlormadinone - Grunenthal - AdisInsight".
  40. "Ethinylestradiol/Drospirenone - AdisInsight".
  41. "GSK 1940029 - AdisInsight".
  42. "GT 20029 - AdisInsight".
  43. "IP10 C8 - AdisInsight".
  44. "Minocycline extended release - Sun Pharma - AdisInsight".
  45. "Minocycline topical - Hovione - AdisInsight".
  46. "MTC 896 - AdisInsight".
  47. "Nitric oxide - Sanotize Research and Development - AdisInsight".
  48. "ORG 101 - AdisInsight".
  49. "Radezolid - Melinta Therapeutics - AdisInsight".
  50. "Research programme: Antimicrobial therapies - NovaBiotics - AdisInsight".
  51. "Research programme: Synthetic cannabinoid therapeutics - Claritas Pharmaceuticals - AdisInsight".
  52. "Research programme: Therapeutic antibody fragments - Kuur Therapeutics - AdisInsight".
  53. "Silver dihydrogen citrate - AdisInsight".
  54. "Tazarotene topical - Dr Reddys Laboratories - AdisInsight".
  55. "Acebilustat - Celtaxsys - AdisInsight".
  56. "Afamelanotide - Clinuvel Pharmaceuticals - AdisInsight".
  57. "BBI 3000 - AdisInsight".
  58. "BMX 010 - AdisInsight".
  59. "Botulinum toxin a liquid - Eirion Therapeutics - AdisInsight".
  60. "Botulinum toxin a topical - AbbVie - AdisInsight".
  61. "Cioteronel - AdisInsight".
  62. "Diroleuton - DS Biopharma - AdisInsight".
  63. "DMVT 503 - AdisInsight".
  64. "DX 0385 - AdisInsight".
  65. "Encapsulated tretinoin cream - Sol-Gel - AdisInsight".
  66. "Epristeride - AdisInsight".
  67. "Falecalcitriol - AdisInsight".
  68. "Gevokizumab - Novartis - AdisInsight".
  69. "Hypochlorous acid - ESSA Pharma - AdisInsight".
  70. "Imsidolimab - AnaptysBio - AdisInsight".
  71. "Incyclinide - AdisInsight".
  72. "Ingenol disoxate - LEO Pharma - AdisInsight".
  73. "JNJ 10229570 AAA - AdisInsight".
  74. "MDI 301 - AdisInsight".
  75. "MK 434 - AdisInsight".
  76. "MTCH 24 - AdisInsight".
  77. "PF 06423264 - AdisInsight".
  78. "PSK 3841 - AdisInsight".
  79. "Research programme: Acne therapeutics - Praxis - AdisInsight".
  80. "Research programme: Tetracycline derivatives - Paratek Pharmaceuticals - AdisInsight".
  81. "Rose bengal sodium - Provectus Biopharmaceuticals - AdisInsight".
  82. "Santalum album ointment - Santalis Healthcare - AdisInsight".
  83. "Talarozole - AdisInsight".
  84. "Thykamine - Devonian - AdisInsight".
  85. "Valproic acid topical - TopoTarget - AdisInsight".
  86. "XEN 801 - AdisInsight".
  87. "XOMA 629 - AdisInsight".
  88. "Zileuton - AbbVie/Chiesi USA - AdisInsight".
  89. "Isotretinoin topical - LEO Pharma - AdisInsight".
  90. "Adapalene - Galderma - AdisInsight".
  91. "Azelaic acid - Leo Pharma - AdisInsight".
  92. "Benzoyl peroxide - Maruho - AdisInsight".
  93. "Clascoterone - Cosmo Pharmaceuticals - AdisInsight".
  94. "Clindamycin - ULURU - AdisInsight".
  95. "Dapsone topical - Almirall S.A. - AdisInsight".
  96. "Doxycycline hyclate - Aqua Pharmaceuticals - AdisInsight".
  97. "Isotretinoin - Cipher Pharmaceuticals - AdisInsight".
  98. "Minocycline - Dr Reddys Laboratories/Journey Medical Corporation - AdisInsight".
  99. "Minocycline foam - Journey Medical Corporation - AdisInsight".
  100. "Nadifloxacin - Otsuka Pharmaceutical - AdisInsight".
  101. "Ozenoxacin - Ferrer/Maruho - AdisInsight".
  102. "Sarecycline - Almirall S.A./Paratek Pharmaceuticals - AdisInsight".
  103. "Solubilised benzoyl peroxide - Obagi Medical Products - AdisInsight".
  104. "Tazarotene topical - Almirall S.A. - AdisInsight".
  105. "Tretinoin - Roche - AdisInsight".
  106. "Tretinoin lotion - Bausch Health/Ortho Dermatologics - AdisInsight".
  107. "Trifarotene - Galderma/Mayne Pharma - AdisInsight".
  108. "Adapalene/Benzoyl peroxide - Galderma - AdisInsight".
  109. "Adapalene/Benzoyl peroxide/Clindamycin phosphate - Bausch Health Companies - AdisInsight".
  110. "Benzoyl peroxide/Clindamycin - Stiefel Laboratories - AdisInsight".
  111. "Benzoyl peroxide/Clindamycin low dose - Ortho Dermatologics - AdisInsight".
  112. "Benzoyl peroxide/Tretinoin - Sol-Gel Technologies - AdisInsight".
  113. "Clindamycin/Tretinoin - Ortho Dermatologics - AdisInsight".
  114. "Drospirenone/Ethinylestradiol low-dose - Bayer HealthCare Pharmaceuticals - AdisInsight".
  115. "Ethinylestradiol/Drospirenone/Levomefolic acid - Bayer - AdisInsight".
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