Dienogest

Last updated
Dienogest
Dienogest.svg
Dienogest molecule ball.png
Clinical data
Trade names Alone: Dinagest, Visanne, Zalkya
With EV Tooltip estradiol valerate: Natazia, Qlaira
With EE Tooltip ethinylestradiol: Valette
Other namesDNG; Dienogestril; Cyanomethyldienolone; BAY 86-5258; Endometrion; M-18575; MJR-35; SH-660; SH-T00660AA; STS-557; ZK-37659; δ9-17α-Cyanomethyl-19-nortestosterone; 17α-Cyanomethylestra-4,9(10)-dien-17β-ol-3-one; 17β-Hydroxy-3-oxo-19-nor-17α-pregna-4,9-diene-21-nitrile
AHFS/Drugs.com International Drug Names
Pregnancy
category
  • AU:B3
Routes of
administration
By mouth [1] [2]
Drug class Progestogen; Progestin; Steroidal antiandrogen
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
Pharmacokinetic data
Bioavailability 90% [3]
Protein binding Albumin: 90% [3]
Free: 10% [3]
Metabolism Liver (reduction, hydroxylation via CYP3A4, removal of cyanomethyl group, conjugation) [3] [4]
Metabolites • 9α,10β-Dihydro-DNG [1]
• 3,5α-Tetrahydro-DNG [1]
(Both said to be inactive) [2] [3]
Elimination half-life 7.5–10.7 hours [2]
Excretion Urine [5]
Identifiers
  • 2-[(8S,13S,14S,17R)-17-hydroxy-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]acetonitrile
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.167.087 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C20H25NO2
Molar mass 311.425 g·mol−1
3D model (JSmol)
Density 1.2 g/cm3
Melting point 210 to 218 °C (410 to 424 °F) (experimental)
Boiling point 549 °C (1,020 °F)
  • C[C@]12CCC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@]2(CC#N)O
  • InChI=1S/C20H25NO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-10H2,1H3/t17-,18+,19+,20-/m1/s1 X mark.svgN[ pubchem ]
  • Key:AZFLJNIPTRTECV-FUMNGEBKSA-N X mark.svgN[ pubchem ]
   (verify)

Dienogest, sold under the brand name Visanne among others, is a progestin medication which is used in birth control pills and in the treatment of endometriosis. [6] [7] [1] [8] [9] [10] It is also used in menopausal hormone therapy and to treat heavy periods. [8] [11] [12] Dienogest is available both alone and in combination with estrogens. [13] [11] It is taken by mouth. [1]

Contents

Side effects of dienogest include menstrual irregularities, headaches, nausea, breast tenderness, depression, and acne, among others. [14] Dienogest is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. [1] [2] It is a unique progestogen, with strong effects in the uterus. [2] The medication has some antiandrogenic activity, which may help to improve androgen-dependent symptoms like acne, and has no other important hormonal activity. [1] [2] [7] [15] [16]

Dienogest was discovered in 1979 and was introduced for medical use in 1995. [17] [18] [19] Additional formulations of dienogest were approved between 2007 and 2010. [10] [20] It is sometimes referred to as a "fourth-generation" progestin. [21] [22] Dienogest is marketed widely throughout the world. [13] It is available as a generic medication. [23]

Medical uses

Birth control

Dienogest is used primarily in birth control pills in combination with ethinylestradiol under the brand name Valette. [24] [7] [25] It is also available in a quadriphasic birth control pill combined with estradiol valerate, marketed as Natazia in the United States and Qlaira in some European countries and Russia. [26] [27] [28]

Endometriosis

Dienogest is approved as a standalone medication under the brand names Visanne and Dinagest in various places such as Europe, Australia, Japan, Singapore, and Malaysia for the treatment of endometriosis. [29] [10] [30] It has been found to be equally effective as gonadotropin-releasing hormone agonists (GnRH agonists), such as leuprorelin, in the treatment of endometriosis. [29]

Heavy periods

Birth control pills containing dienogest and estradiol valerate are approved in the United States for the treatment of menorrhagia (heavy menstrual bleeding). [12]

Menopausal symptoms

Dienogest is used in combination with estradiol valerate in the treatment of menopausal symptoms in certain countries such as Germany and the Netherlands. [8] [11]

Available forms

Dienogest is available both alone and in combination with estrogens. [13] [11] The following formulations are available: [13] [11]

The availability of these formulations differs by country (see Availability). [13]

Contraindications

Contraindications of dienogest include active venous thromboembolism, previous or current cardiovascular disease, diabetes with cardiovascular complications, previous or current severe liver disease or tumors, hormone-dependent cancers such as breast cancer, and undiagnosed vaginal bleeding. [10] [33]

Side effects

Side effects associated with dienogest are the same as those expected of a progestogen. [7] They include menstrual irregularities, headaches, nausea, breast tenderness, depression, acne, weight gain, flatulence, and others. [14] Dienogest produces no androgenic side effects and has little effect on metabolic and lipid hemostatic parameters. [34]

Birth control pills containing estradiol valerate/dienogest are associated with a significantly increased risk of venous thromboembolism. [35] However, they are associated with a significantly lower risk of venous thromboembolism than birth control pills containing ethinylestradiol and a progestin. [35]

Overdose

In safety studies, dienogest has been assessed in women with endometriosis at high doses of as much as 20 mg/day for up to 24 weeks and produced no clinically relevant effects on lipid metabolism, liver enzymes, the coagulatory system, or thyroid metabolism. [11]

Interactions

Dienogest is metabolized mainly by the cytochrome P450 enzyme CYP3A4, [3] [10] and for this reason, inhibitors and inducers of CYP3A4 can alter the amount of exposure to dienogest when administered concomitantly with it. [10] (For a list of CYP3A4 inhibitors and inducers, see here.) The strong CYP3A4 inhibitors ketoconazole and erythromycin have been found to increase exposure to dienogest by up to 3-fold, whereas the strong CYP3A4 inducer rifampicin (rifampin) was found to decrease steady-state and area-under-curve concentrations of dienogest by 50% and 80%, respectively. [10]

Pharmacology

Pharmacodynamics

Dienogest has progestogenic activity, possibly some antiprogestogenic activity, and has antiandrogenic activity. [2] [7] [1] [3] The medication does not interact with the estrogen receptor, the glucocorticoid receptor, or the mineralocorticoid receptor, and hence has no estrogenic, glucocorticoid, or antimineralocorticoid activity. [2] [7] [1] [3] Because of its relatively high selectivity as a progestogen, dienogest may have favorable safety and tolerability compared to various other progestins. [1] [2]

Relative affinities (%) of dienogest and metabolites
Compound PR Tooltip Progesterone receptor AR Tooltip Androgen receptor ER Tooltip Estrogen receptor GR Tooltip Glucocorticoid receptor MR Tooltip Mineralocorticoid receptor SHBG Tooltip Sex hormone-binding globulin CBG Tooltip Corticosteroid binding globulin
Dienogest51001000
9α,10β-Dihydrodienogest2613 ? ? ? ? ?
3α,5α-Tetrahydrodienogest1916 ? ? ? ? ?
Notes: Values are percentages (%). Reference ligands (100%) were promegestone for the PR Tooltip progesterone receptor, metribolone for the AR Tooltip androgen receptor, estradiol for the ER Tooltip estrogen receptor, dexamethasone for the GR Tooltip glucocorticoid receptor, aldosterone for the MR Tooltip mineralocorticoid receptor, DHT Tooltip dihydrotestosterone for SHBG Tooltip sex hormone-binding globulin, and cortisol for CBG Tooltip Corticosteroid-binding globulin. Sources: [1]

Progestogenic activity

Dienogest is an agonist of the progesterone receptor (PR), and hence is a progestogen. [2] [7] [1] It has relatively weak affinity for the PR in vitro in human uterine tissue, about 10% that of progesterone. [2] [7] [3] Despite its low affinity for the PR however, dienogest has high progestogenic activity in vivo . [2] In addition, although its metabolites, such as 9α,10β-dihydrodienogest and 3α,5α-tetrahydrodienogest, have greater affinity for the PR than does dienogest itself, the medication is not considered to be a prodrug. [2] [1] [7] [3]

Relative potencies of progestogens [36]
ProgestogenTFD
(mg/cycle)
OID
(mg/day)
TFD/OID
ratio
Chlormadinone acetate 251.71.5
Cyproterone acetate 201.02.0
Dienogest61.00.6
Norethisterone 1200.430
Norethisterone acetate 500.510
Norgestimate 70.23.5
Levonorgestrel 50.068.3
Desogestrel 20.063.3
Gestodene 30.047.5
Drospirenone 502.02.5
Nomegestrol acetate 1005.02.0

Dienogest has been described as "special" progestogen, possessing low or moderate antigonadotropic efficacy but strong or very strong endometrial efficacy. [2] [7] In relation to its endometrial activity, dienogest is said to be one of the strongest progestogens available. [2] The high endometrial activity of dienogest underlies its ability to stabilize the menstrual cycle when combined with either ethinylestradiol or estradiol valerate (which has lower relative effects on the uterus compared to ethinylestradiol) in birth control pills, and also its use in the treatment of endometriosis. [2] The combination of most other progestins with estradiol or an estradiol ester like estradiol valerate as birth control pills was unsatisfactory due to a high incidence of irregular menstrual bleeding. [2] This is a property that ethinylestradiol does not share with estradiol, because of its resistance to metabolism in the endometrium and hence its greater relative effects in this part of the body. [1] In contrast to other progestins, due to its high endometrial efficacy, the combination of dienogest with estradiol valerate in birth control pills is able to prevent breakthrough bleeding, and is uniquely able to treat heavy menstrual bleeding. [2] The absence of withdrawal bleeding, otherwise known as "silent menstruation", also may occur. [2] Dienogest has antiovulatory potency that is similar to that of 17α-hydroxyprogesterone derivatives like cyproterone acetate but endometrial potency that is much stronger and similar to that of gonane 19-nortestosterone progestins like levonorgestrel. [36]

Unlike other progestogens, except in the case of its strong effects in the uterus, dienogest has been described as lacking antiestrogenic effects, and does not antagonize beneficial effects of estradiol, for instance in the metabolic and vascular systems. [2]

Dienogest showed some possible antiprogestogenic activity in one animal bioassay when administered before but not at the same time as progesterone. [7]

The minimum effective dose of oral dienogest required to inhibit ovulation is 1 mg/day. [2] [1] The inhibition of ovulation by dienogest occurs mainly via a direct peripheral action in the ovary of inhibiting folliculogenesis as opposed to a central action of inhibiting gonadotropin secretion. [2] [1] Oral therapy with 2 mg/day dienogest in cyclical premenopausal women reduced serum progesterone levels to anovulatory levels, but circulating levels of luteinizing hormone and follicle-stimulating hormone were not considerably affected. [2] At this dosage, estradiol levels are reduced to early follicular phase levels of about 30 to 50 pg/mL. [2] Such levels are insufficient for reactivation of endometrioses, but are sufficient to avoid menopausal-like symptoms such as hot flashes and bone loss. [2] This is in contrast to gonadotropin-releasing hormone analogues (GnRH analogues), which suppress estradiol levels to lower concentrations and readily induce menopausal-like symptoms. [2]

Dienogest appears to have similar effects in the breasts as norethisterone acetate, and may likewise increase the risk of breast cancer when combined with an estrogen in postmenopausal women, although this has yet to be confirmed in clinical studies. [2]

Antigonadotropic effects

Testosterone levels with 2, 5, or 10 mg/day dienogest, 10 mg/day oral cyproterone acetate, or placebo in healthy young men. Testosterone levels with different doses of dienogest and cyproterone acetate in men.png
Testosterone levels with 2, 5, or 10 mg/day dienogest, 10 mg/day oral cyproterone acetate, or placebo in healthy young men.

Dienogest has been found to suppress testosterone levels in men by 43% at 2 mg/day, 70% at 5 mg/day, and 81% at 10 mg/day. [37] [38] The suppression of testosterone levels with 10 mg/day dienogest was comparable to that with 10 mg/day cyproterone acetate. [38] [37] In general, progestogens are able to suppress testosterone levels in men by a maximum of about 70 to 80% at sufficiently high doses. [39] [40] [41] [42] [43]

Antiandrogenic activity

Dienogest is one of the only 19-nortestosterone derivative progestins that does not have androgenic properties. [1] [2] In fact, it is actually an antagonist of the androgen receptor (AR), and hence has antiandrogenic activity. [2] [3] [1] The antiandrogenic activity of dienogest in the Hershberger test is about 30 to 40% of that of cyproterone acetate. [2] [3] [1] [44] It may be able to improve androgen-dependent symptoms such as acne and hirsutism. [7] [15] [2] Metabolites of dienogest, such as 9α,10β-dihydrodienogest and 3α,5α-tetrahydrodienogest, show greater affinity for the AR than does dienogest itself. [1] Dienogest has no affinity for sex hormone-binding globulin (SHBG), and hence does not displace testosterone or estradiol from this plasma protein or increase the free fractions of these hormones. [2]

Other activities

Dienogest does not inhibit or induce CYP3A4, unlike many other related progestins. [7] [1] Because of this, it may have a lower propensity for drug interactions. [2]

Dienogest weakly stimulates the proliferation of MCF-7 breast cancer cells in vitro , an action that is independent of the classical PRs and is instead mediated via the progesterone receptor membrane component-1 (PGRMC1). [45] Certain other progestins are also active in this assay, whereas progesterone acts neutrally. [45] It is unclear if these findings may explain the different risks of breast cancer observed with progesterone and progestins in clinical studies. [46]

Pharmacokinetics

Dienogest is rapidly absorbed with oral administration and has high bioavailability of approximately 90%. [3] Peak levels of dienogest occur within approximately 2 hours after an oral dose. [7] The pharmacokinetics of dienogest are linear; single oral doses of dienogest were found to result in maximal levels of 28 ng/mL with 1 mg, 54 ng/mL with 2 mg, 101 ng/mL with 4 mg, and 212 ng/mL with 8 mg. [7] The corresponding area-under-the-curve levels were 306, 577, 1153, and 2293 ng/mL, respectively. [7] Dienogest reaches steady-state concentrations within 6 days of continuous administration, and does not accumulate in the body. [7] [3] The plasma protein binding of dienogest is 90%, with a relatively high free fraction of 10%. [7] It is exclusively bound to albumin, with no binding to SHBG or corticosteroid-binding globulin. [2] [7] [3] The lack of affinity of dienogest for SHBG is in contrast to most other 19-nortestosterone progestins. [2] The volume of distribution of dienogest is relatively low at 40 L. [7]

Dienogest is metabolized in the liver. [2] [3] Metabolic pathways of dienogest include reduction of its Δ4-3-keto group, hydroxylation mainly via CYP3A4, removal of its C17α cyanomethyl group, and conjugation. [2] [3] The metabolites of dienogest are quickly excreted and are said to be mostly inactive. [2] The elimination half-life of dienogest is relatively short at approximately 7.5 to 10.7 hours. [2] [7] [3] [4] The short half-life of dienogest relative to other 19-nortestosterone progestins is in part due to its lack of binding to SHBG and hence prolongation in the circulation. [2] The clearance of dienogest is 3 L/h. [7] It is eliminated mainly in the urine, both as sulfate and glucuronide conjugates and as free steroid. [5]

Chemistry

Dienogest, also known as δ9-17α-cyanomethyl-19-nortestosterone or as 17α-cyanomethylestra-4,9-dien-17β-ol-3-one, is a synthetic estrane steroid and a derivative of testosterone. [47] [7] [3] It is a member of the estrane subgroup of the 19-nortestosterone family of progestins, but unlike most other 19-nortestosterone progestins, is not a derivative of norethisterone (17α-ethynyl-19-nortestosterone). [22] [48] [49] This is because it uniquely possesses a cyanomethyl group (i.e., a nitrile group) at the C17α position rather than the usual ethynyl group. [3] [22] It is also unique among most 19-nortestosterone progestins in that it has a double bond between the C9 and C10 positions. [3] Dienogest is the C17α cyanomethyl derivative of the anabolic–androgenic steroid (AAS) dienolone, as well as the C17α cyanomethyl analogue of the AAS methyldienolone (17α-methyldienolone) and ethyldienolone (17α-ethyldienolone). [47]

In terms of structure–activity relationships, the C17α cyanomethyl group of dienogest is responsible for its unique antiandrogenic instead of androgenic activity relative to other 19-nortestosterone progestins. [3] A loss of ability to activate the AR is also seen with other testosterone derivatives with extended-length C17α substitutions such as topterone (propyltestosterone) (compare to the AAS ethyltestosterone and methyltestosterone) and allylestrenol (compare to the AAS ethylestrenol). [50] [51] Studies with steroids similar to dienogest (e.g., dienolone) have found that the introduction of a double bond between the C9 and C10 positions is associated with similar/almost unchanged affinity for the PR and AR. [52] On the other hand, the C9(10) double bond of dienogest appears to inhibit metabolism via 5α-reductase and/or 5β-reductase, which is the major metabolic route for other 19-nortestosterone progestins like norethisterone, norgestrel, and etonogestrel, and this may serve to improve the metabolic stability and potency of dienogest. [53] [54]

History

Dienogest was synthesized in 1979 in Jena, Germany under the leadership of Kurt Ponsold, was initially referred to as STS-557. [17] [18] It was found that its potency was 10 times that of levonorgestrel. [55] The first product on the market to contain dienogest was a combined birth control pill (with ethinylestradiol), Valette, introduced in 1995 and made by Jenapharm. [19] In 2007, dienogest was introduced as Dinagest in Japan for the treatment of endometriosis, and it was subsequently marketed for this indication as Visanne in Europe and Australia in December 2009 and April 2010, respectively. [10] Qlaira was introduced in Europe in 2009 and Natazia was introduced in the United States in 2010. [20]

Society and culture

Generic names

Dienogest is the generic name of the drug and its INN Tooltip International Nonproprietary Name, USAN Tooltip United States Adopted Name, BAN Tooltip British Approved Name, and JAN Tooltip Japanese Accepted Name, while diénogest is its DCF Tooltip Dénomination Commune Française. [47] [13] It is also known by its synonyms dienogestril and cyanomethyldienolone as well as by its numerous former developmental code names including BAY 86-5258, M-18575, MJR-35, SH-660, SH-T00660AA, STS-557, and ZK-37659. [47] [13]

Brand names

Dienogest is marketed in combination with estradiol valerate as a birth control pill primarily under the brand names Natazia and Qlaira and in combination with ethinylestradiol as a birth control pill primarily under the brand name Valette, although these combinations are marketed under numerous other brand names as well. [13] In the case of the dienogest and estradiol valerate birth control pill, these other brand names include Gianda and Klaira. [13] Dienogest is also marketed in combination with estradiol valerate for use in menopausal hormone therapy under a variety of brand names including Climodien, Climodiène, Estradiol Valeraat / Dienogest, Klimodien, lafamme, Lafleur, Mevaren, Valerix, and Velbienne. [13] Dienogest is marketed as a standalone medication for the treatment of endometriosis primarily under the brand name Visanne, but is also available under the brand names Alondra, Dinagest, Disven, Visabelle, and Visannette in various countries. [13]

Availability

Known availability of dienogest in countries throughout the world (as of August 2018). Alone is dienogest as a standalone medication. EV is estradiol valerate and EE is ethinylestradiol. Dienogest availability.png
Known availability of dienogest in countries throughout the world (as of August 2018). Alone is dienogest as a standalone medication. EV is estradiol valerate and EE is ethinylestradiol.

Dienogest is available both alone and in combination with ethinylestradiol and estradiol valerate widely throughout the world, including but not limited to Canada, Europe, Latin America, and Southeast Asia. [13] [56] It is available specifically as a standalone medication in Canada, Europe, Latin America, Russia, Australia, South Africa, Georgia, Israel, Japan, South Korea, Hong Kong, and Thailand. [13] [56] It is notably not available as a standalone medication in the United States or the United Kingdom. [13] [56]

Research

Dienogest has been studied as a form of male hormonal contraception. [57] [37] [58] As of July 2018, dienogest is in phase III clinical trials in Japan for the treatment of adenomyosis and dysmenorrhea. [8] The combination of estradiol valerate and dienogest is in pre-registration in Europe for the treatment of acne. [59] Dienogest is also being evaluated for the potential treatment of anorexia nervosa. [60]

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Nomegestrol acetate (NOMAC), sold under the brand names Lutenyl and Zoely among others, is a progestin medication which is used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders. It is available both alone and in combination with an estrogen. NOMAC is taken by mouth. A birth control implant for placement under the skin was also developed but ultimately was not marketed.

<span class="mw-page-title-main">Segesterone acetate</span> Progestin medication

Segesterone acetate (SGA), sold under the brand names Nestorone, Elcometrine, and Annovera, is a progestin medication which is used in birth control and in the treatment of endometriosis in the United States, Brazil, and other South American countries. It is available both alone and in combination with an estrogen. It is not effective by mouth and must be given by other routes, most typically as a vaginal ring or implant that is placed into fat.

Combined birth control pills that contain natural estradiol or an estradiol ester include:

<span class="mw-page-title-main">Estradiol (medication)</span> Steroidal hormone medication

Estradiol (E2) is a medication and naturally occurring steroid hormone. It is an estrogen and is used mainly in menopausal hormone therapy and to treat low sex hormone levels in women. It is also used in hormonal birth control for women, in feminizing hormone therapy for transgender women, and in the treatment of hormone-sensitive cancers like prostate cancer in men and breast cancer in women, among other uses. Estradiol can be taken by mouth, held and dissolved under the tongue, as a gel or patch that is applied to the skin, in through the vagina, by injection into muscle or fat, or through the use of an implant that is placed into fat, among other routes.

<span class="mw-page-title-main">Estradiol valerate/dienogest</span> Combination drug

Estradiol valerate/dienogest (EV/DNG), sold under the brand names Lafamme, Natazia and Qlaira among others, is a combination product of estradiol valerate, an estrogen, and dienogest, a progestogen, which is used in menopausal hormone therapy in and as a birth control pill to prevent pregnancy in women. It is taken by mouth.

References

  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 Kuhl H (August 2005). "Pharmacology of estrogens and progestogens: influence of different routes of administration". Climacteric. 8 (Suppl 1): 3–63. doi:10.1080/13697130500148875. PMID   16112947. S2CID   24616324.
  2. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 Ruan X, Seeger H, Mueck AO (April 2012). "The pharmacology of dienogest". Maturitas. 71 (4): 337–344. doi:10.1016/j.maturitas.2012.01.018. PMID   22364708.
  3. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 Bińkowska M, Woroń J (June 2015). "Progestogens in menopausal hormone therapy". Przeglad Menopauzalny = Menopause Review. 14 (2): 134–143. doi:10.5114/pm.2015.52154. PMC   4498031 . PMID   26327902.
  4. 1 2 Stanczyk FZ (November 2003). "All progestins are not created equal". Steroids. 68 (10–13): 879–890. doi:10.1016/j.steroids.2003.08.003. PMID   14667980. S2CID   44601264.
  5. 1 2 Bizzarri N, Remorgida V, Leone Roberti Maggiore U, Scala C, Tafi E, Ghirardi V, et al. (September 2014). "Dienogest in the treatment of endometriosis". Expert Opinion on Pharmacotherapy. 15 (13): 1889–1902. doi:10.1517/14656566.2014.943734. PMID   25069386. S2CID   37627607.
  6. "TGA eBS - Product and Consumer Medicine Information Licence".
  7. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 Foster RH, Wilde MI (November 1998). "Dienogest". Drugs. 56 (5): 825–33, discussion 834–5. doi:10.2165/00003495-199856050-00007. PMID   9829156. S2CID   262326901.
  8. 1 2 3 4 "Dienogest - Bayer HealthCare Pharmaceuticals/Mochida Pharmaceutical - AdisInsight".
  9. Stanczyk FZ, Bretsky (22 May 2013). "Biosynthesis, Transport, and Metabolism of Steroid Hormones". In Falcone T, Hurd WW (eds.). Clinical Reproductive Medicine and Surgery: A Practical Guide. Springer Science & Business Media. pp. 300–. ISBN   978-1-4614-6837-0. Dienogest is a 19-nortestosterone derivative that is approved in the European Union for the treatment of endometriosis. It is not available in the United States as a separate drug. It is only available in the oral contraceptive Natazia (Bayer Pharmaceuticals, Montville, NJ, USA) (estradiol valerate/dienogest), which is a newer four-phasic pack that contains dienogest.
  10. 1 2 3 4 5 6 7 8 McCormack PL (November 2010). "Dienogest: a review of its use in the treatment of endometriosis". Drugs. 70 (16): 2073–2088. doi:10.2165/11206320-000000000-00000. PMID   20964453. S2CID   249871173.
  11. 1 2 3 4 5 6 Bartsch V, Römer T (2015). "Gynaecological uses of dienogest alone and in combination with oestrogens" (PDF). J Med Drug Rev. 5: 1–31.
  12. 1 2 3 Micks EA, Jensen JT (January 2013). "Treatment of heavy menstrual bleeding with the estradiol valerate and dienogest oral contraceptive pill". Advances in Therapy. 30 (1): 1–13. doi:10.1007/s12325-012-0071-3. PMID   23239397. S2CID   31125733.
  13. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 "Dienogest".
  14. 1 2 "Dienogest". Australian Prescriber. 38 (4): 138–139. August 2015. doi:10.18773/austprescr.2015.050. PMC   4653971 . PMID   26648643.
  15. 1 2 Raudrant D, Rabe T (2003). "Progestogens with antiandrogenic properties". Drugs. 63 (5): 463–492. doi:10.2165/00003495-200363050-00003. PMID   12600226. S2CID   28436828.
  16. Regidor PA, Schindler AE (October 2017). "Antiandrogenic and antimineralocorticoid health benefits of COC containing newer progestogens: dienogest and drospirenone". Oncotarget. 8 (47): 83334–83342. doi:10.18632/oncotarget.19833. PMC   5669973 . PMID   29137347.
  17. 1 2 Menzenbach B, Hübner M, Ponsold K (1984). "Untersuchungen zur Bromierung/Dehydrobromierung von 17-Cyanmethyl-17-hydroxy-östr-5(10)-en-3-on". Journal für Praktische Chemie. 326 (6): 893–898. doi:10.1002/prac.19843260606.
  18. 1 2 Kaufmann G, Dautzenberg H, Henkel H, Müller G, Schäfer T, Undeutsch B, Oettel M (August 1999). "Nitrile hydratase from Rhodococcus erythropolis: metabolization of steroidal compounds with a nitrile group". Steroids. 64 (8): 535–540. doi:10.1016/S0039-128X(99)00028-8. PMID   10493599. S2CID   21769309.
  19. 1 2 "Die Jahre 1965 - 1995". Archived from the original on 2008-03-07. Retrieved 2008-01-18.
  20. 1 2 Guida M, Bifulco G, Di Spiezio Sardo A, Scala M, Fernandez LM, Nappi C (August 2010). "Review of the safety, efficacy and patient acceptability of the combined dienogest/estradiol valerate contraceptive pill". International Journal of Women's Health. 2: 279–290. doi: 10.2147/IJWH.S6954 . PMC   2990895 . PMID   21151673.
  21. Hall S, Gebbie AE (11 July 2013). "Progestogens used in Contraceptives". In Briggs P, Kovacs G (eds.). Contraception: A Casebook from Menarche to Menopause. Cambridge University Press. pp. 52–. ISBN   978-1-107-43611-4.
  22. 1 2 3 Bitzer J (9 April 2015). "Progestogens in Contraception". In Carp HJ (ed.). Progestogens in Obstetrics and Gynecology. Springer. pp. 112–113, 170–. ISBN   978-3-319-14385-9.
  23. "Generic Natazia Availability".
  24. Pérez-Campos EF (April 2010). "Ethinylestradiol/dienogest in oral contraception". Drugs. 70 (6): 681–689. doi:10.2165/11536320-000000000-00000. PMID   20394455. S2CID   46374974.
  25. Wiegratz I, Mittmann K, Dietrich H, Zimmermann T, Kuhl H (June 2006). "Fertility after discontinuation of treatment with an oral contraceptive containing 30 microg of ethinyl estradiol and 2 mg of dienogest". Fertility and Sterility. 85 (6): 1812–1819. doi: 10.1016/j.fertnstert.2005.11.052 . PMID   16759929.
  26. Hoy SM, Scott LJ (August 2009). "Estradiol valerate/dienogest: in oral contraception". Drugs. 69 (12): 1635–1646. doi:10.2165/11202820-000000000-00000. PMID   19678714. S2CID   207297417.
  27. Whalen KL, Rose R (October 2011). "Estradiol valerate/dienogest: a novel oral contraceptive". The Annals of Pharmacotherapy. 45 (10): 1256–1261. doi:10.1345/aph.1Q216. PMID   21917554. S2CID   33366375.
  28. Fruzzetti F, Trémollieres F, Bitzer J (May 2012). "An overview of the development of combined oral contraceptives containing estradiol: focus on estradiol valerate/dienogest". Gynecological Endocrinology. 28 (5): 400–408. doi:10.3109/09513590.2012.662547. PMC   3399636 . PMID   22468839.
  29. 1 2 Andres M, Lopes LA, Baracat EC, Podgaec S (September 2015). "Dienogest in the treatment of endometriosis: systematic review". Archives of Gynecology and Obstetrics. 292 (3): 523–529. doi:10.1007/s00404-015-3681-6. PMID   25749349. S2CID   22168242.
  30. "Dienogest for the treatment of endometriosis" (PDF). London New Drugs Group. Archived from the original (PDF) on 2011-10-02. Retrieved 2010-12-07.
  31. "Highlights of Prescribing Information" (PDF). Natazia website. Bayer. Retrieved 16 January 2023.
  32. "Qlaira Tablets". NPS Medicinewise Australia. 13 July 2020.
  33. "Visanne, tablets, 2 mg Bayer BV, The Netherlands (dienogest)" (PDF). Medicines Evaluation Board. The Netherlands. 3 March 2010.
  34. Wiegratz I, Lee JH, Kutschera E, Bauer HH, von Hayn C, Moore C, et al. (March 2002). "Effect of dienogest-containing oral contraceptives on lipid metabolism". Contraception. 65 (3): 223–229. doi:10.1016/S0010-7824(01)00310-9. PMID   11929644.
  35. 1 2 Fruzzetti F, Cagnacci A (2018). "Venous thrombosis and hormonal contraception: what's new with estradiol-based hormonal contraceptives?". Open Access Journal of Contraception. 9: 75–79. doi: 10.2147/OAJC.S179673 . PMC   6239102 . PMID   30519125.
  36. 1 2 Wiegratz I, Kuhl H (September 2006). "Metabolic and clinical effects of progestogens". The European Journal of Contraception & Reproductive Health Care. 11 (3): 153–161. doi:10.1080/13625180600772741. PMID   17056444. S2CID   27088428.
  37. 1 2 3 4 Meriggiola MC, Bremner WJ, Costantino A, Bertaccini A, Morselli-Labate AM, Huebler D, et al. (May 2002). "Twenty-one day administration of dienogest reversibly suppresses gonadotropins and testosterone in normal men". The Journal of Clinical Endocrinology and Metabolism. 87 (5): 2107–2113. doi: 10.1210/jcem.87.5.8514 . hdl: 1773/4465 . PMID   11994349.
  38. 1 2 Nieschlag E, Zitzmann M, Kamischke A (November 2003). "Use of progestins in male contraception". Steroids. 68 (10–13): 965–972. doi:10.1016/S0039-128X(03)00135-1. PMID   14667989. S2CID   22458746.
  39. Wein AJ, Kavoussi LR, Novick AC, Partin AW, Peters CA (25 August 2011). Campbell-Walsh Urology: Expert Consult Premium Edition: Enhanced Online Features and Print, 4-Volume Set. Elsevier Health Sciences. pp. 2938–. ISBN   978-1-4160-6911-9.
  40. Knuth UA, Hano R, Nieschlag E (November 1984). "Effect of flutamide or cyproterone acetate on pituitary and testicular hormones in normal men". The Journal of Clinical Endocrinology and Metabolism. 59 (5): 963–969. doi:10.1210/jcem-59-5-963. PMID   6237116.
  41. Jacobi GH, Altwein JE, Kurth KH, Basting R, Hohenfellner R (June 1980). "Treatment of advanced prostatic cancer with parenteral cyproterone acetate: a phase III randomised trial". British Journal of Urology. 52 (3): 208–215. doi:10.1111/j.1464-410x.1980.tb02961.x. PMID   7000222.
  42. Sander S, Nissen-Meyer R, Aakvaag A (1978). "On gestagen treatment of advanced prostatic carcinoma". Scandinavian Journal of Urology and Nephrology. 12 (2): 119–121. doi:10.3109/00365597809179977. PMID   694436.
  43. Kjeld JM, Puah CM, Kaufman B, Loizou S, Vlotides J, Gwee HM, et al. (November 1979). "Effects of norgestrel and ethinyloestradiol ingestion on serum levels of sex hormones and gonadotrophins in men". Clinical Endocrinology. 11 (5): 497–504. doi:10.1111/j.1365-2265.1979.tb03102.x. PMID   519881. S2CID   5836155.
  44. Sitruk-Ware R, Husmann F, Thijssen JH, Skouby SO, Fruzzetti F, Hanker J, et al. (September 2004). "Role of progestins with partial antiandrogenic effects". Climacteric. 7 (3): 238–254. doi:10.1080/13697130400001307. PMID   15669548. S2CID   23112620.
  45. 1 2 Neubauer H, Ma Q, Zhou J, Yu Q, Ruan X, Seeger H, et al. (October 2013). "Possible role of PGRMC1 in breast cancer development". Climacteric. 16 (5): 509–513. doi:10.3109/13697137.2013.800038. PMID   23758160. S2CID   29808177.
  46. Trabert B, Sherman ME, Kannan N, Stanczyk FZ (April 2020). "Progesterone and Breast Cancer". Endocrine Reviews. 41 (2): 320–344. doi:10.1210/endrev/bnz001. PMC   7156851 . PMID   31512725.
  47. 1 2 3 4 Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 390–. ISBN   978-1-4757-2085-3.
  48. Brucker MC, Likis FE (8 September 2015). "Steroid Hormones". In Brucker MC, King TL (eds.). Pharmacology for Women's Health. Jones & Bartlett Publishers. pp. 368–. ISBN   978-1-284-05748-5.
  49. Melo J, Creinin MD (28 September 2015). "Combination Oral Contraceptive Pills". In Shoupe D, Mishell Jr DR (eds.). The Handbook of Contraception: A Guide for Practical Management. Humana Press. pp. 63–. ISBN   978-3-319-20185-6.
  50. Singh SM, Gauthier S, Labrie F (February 2000). "Androgen receptor antagonists (antiandrogens): structure-activity relationships". Current Medicinal Chemistry. 7 (2): 211–247. doi:10.2174/0929867003375371. PMID   10637363.
  51. Bergink EW, Loonen PB, Kloosterboer HJ (August 1985). "Receptor binding of allylestrenol, a progestagen of the 19-nortestosterone series without androgenic properties". Journal of Steroid Biochemistry. 23 (2): 165–168. doi:10.1016/0022-4731(85)90232-8. PMID   3928974.
  52. Ojasoo T, Delettré J, Mornon JP, Turpin-VanDycke C, Raynaud JP (1987). "Towards the mapping of the progesterone and androgen receptors". Journal of Steroid Biochemistry. 27 (1–3): 255–269. doi:10.1016/0022-4731(87)90317-7. PMID   3695484.
  53. Schubert K, Schumann G, Kaufmann G (January 1983). "Influence of a 9-double bond on stereospecific microbial 4,5-reductions". Journal of Steroid Biochemistry. 18 (1): 75–80. doi:10.1016/0022-4731(83)90333-3. PMID   6683343.
  54. Hobe G, Schön R, Hajek M, Undisz K, Härtl A (1998). "Studies on the hydrogenation of the progestagen dienogest in vivo and in vitro in the female rabbit". Steroids. 63 (7–8): 393–400. doi:10.1016/s0039-128x(98)00014-2. PMID   9654645. S2CID   9659302.
  55. Oettel M, Kurischko A (January 1980). "STS 557, a new orally active progestin with antiprogestational and contragestational properties in rabbits". Contraception. 21 (1): 61–69. doi:10.1016/0010-7824(80)90140-7. PMID   7357870.
  56. 1 2 3 Sweetman, Sean C., ed. (2009). "Sex hormones and their modulators". Martindale: The Complete Drug Reference (36th ed.). London: Pharmaceutical Press. p. 2094. ISBN   978-0-85369-840-1.
  57. Manetti GJ, Honig SC (2010). "Update on male hormonal contraception: is the vasectomy in jeopardy?". International Journal of Impotence Research. 22 (3): 159–170. doi:10.1038/ijir.2010.2. PMID   20336073. S2CID   21283244.
  58. Misro MM, Chaki SP, Kaushik MC, Nandan D (June 2009). "Trials for development of once-a-month injectable, hormonal male contraceptive using dienogest plus testosterone undecanoate: dose standardization, efficacy and reversibility studies in rats". Contraception. 79 (6): 488–497. doi:10.1016/j.contraception.2009.01.003. PMID   19442786.
  59. "Estradiol valerate/dienogest - AdisInsight".
  60. Paslakis G, Maas S, Gebhardt B, Mayr A, Rauh M, Erim Y (April 2018). "Prospective, randomized, double-blind, placebo-controlled phase IIa clinical trial on the effects of an estrogen-progestin combination as add-on to inpatient psychotherapy in adult female patients suffering from anorexia nervosa". BMC Psychiatry. 18 (1): 93. doi: 10.1186/s12888-018-1683-1 . PMC   5891970 . PMID   29631553.

Further reading