Dienedione

Last updated
Dienedione
Dienedione.svg
Clinical data
Other names19-Nor-4,9(10)-androstadienedione; Estradienedione, 19-Norandrosta-4,9(10)-diene-3,17-dione; Estra-4,9(10)-diene-3,17-dione
Routes of
administration
Oral
Legal status
Legal status
Identifiers
  • 13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,17-dione
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
ECHA InfoCard 100.112.341 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C18H22O2
Molar mass 270.372 g·mol−1
3D model (JSmol)
  • CC12CCC3=C4CCC(=O)C=C4CCC3C1CCC2=O
   (verify)

Dienedione, also known as estra-4,9-diene-3,17-dione, is a synthetic, orally active anabolic-androgenic steroid (AAS) of the 19-nortestosterone group that was never introduced for medical use. It is thought to be a prohormone of dienolone. [1] The drug became a controlled substance in the US on January 4, 2010, [2] and is classified as a Schedule III anabolic steroid under the United States Controlled Substances Act. Previous to this, it was sold as a bodybuilding supplement within the United States, and often mistakenly marketed as a prohormone for trenbolone, a veterinary steroid. Prior to its scheduling, it was part of a number of supplements that were seized during FDA enforcement of Bodybuilding.com for selling unapproved new drugs. [3] The actual active metabolite, dienolone, is almost identical to trenbolone structurally, but lacks the C11 double bond.

See also

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<span class="mw-page-title-main">Dienolone</span> Chemical compound

Dienolone, or nordienolone, also known as 19-nor-δ9(10)-testosterone, δ9(10)-nandrolone, or estra-4,9(10)-dien-17β-ol-3-one, is a synthetic anabolic-androgenic steroid (AAS) of the 19-nortestosterone group that was never marketed. It has been found to possess slightly lower affinity for the androgen receptor (AR) and progesterone receptor (PR) relative to nandrolone in rat and rabbit tissue bioassays, whereas trenbolone was found to possess the same affinity for the AR as dienolone but several-fold increased affinity for the PR. Dienedione is thought to be a prohormone of dienolone, while methyldienolone and ethyldienolone are orally active 17α-alkylated AAS derivatives of dienolone. In contrast, dienogest, the 17α-cyanomethyl derivative of dienolone, is a potent progestogen and antiandrogen.

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Trendione, also known as estra-4,9,11-triene-3,17-dione, is an androgen prohormone as well as metabolite of the anabolic steroid trenbolone. Trendione is to trenbolone as androstenedione is to testosterone. The compound is inactive itself, showing more than 100-fold lower affinity for the androgen and progesterone receptors than trenbolone. It is a designer steroid and has been sold on the internet as a "nutritional supplement". Trendione is listed in the United States Designer Anabolic Steroid Control Act of 2014.

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References

  1. "Rules - 2009 - Final Rule: Classification of Three Steroids as Schedule III Anabolic Steroids Under the Controlled Substances Act". www.deadiversion.usdoj.gov. Retrieved 1 June 2017.
  2. "Rules - 2009 - Final Rule: Classification of Three Steroids as Schedule III Anabolic Steroids Under the Controlled Substances Act". www.deadiversion.usdoj.gov. Retrieved 1 June 2017.
  3. Office of Regulatory Affairs. "Enforcement Reports - Enforcement Report for July 7, 2010". www.fda.gov. Retrieved 1 June 2017.