Trendione

Last updated
Trendione
Trendione.svg
Clinical data
Other namesRU-2065; Trenavar; Triendione; Estra-4,9,11-triene-3,17-dione
Drug class Androgen; Anabolic steroid; Progestogen
Identifiers
  • (8S,13S,14S)-13-Methyl-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C18H20O2
Molar mass 268.356 g·mol−1
3D model (JSmol)
  • C[C@]12C=CC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CCC2=O
  • InChI=1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h8-10,15-16H,2-7H2,1H3/t15-,16+,18+/m1/s1
  • Key:KBSXJBBFQODDTQ-RYRKJORJSA-N

Trendione (developmental code name RU-2065; nickname Trenavar), also known as estra-4,9,11-triene-3,17-dione, is an androgen prohormone as well as metabolite of the anabolic steroid trenbolone. [1] [2] [3] [4] [5] Trendione is to trenbolone as androstenedione is to testosterone. [6] The compound is inactive itself, showing more than 100-fold lower affinity for the androgen and progesterone receptors than trenbolone. [7] [8] It is a designer steroid and has been sold on the internet as a "nutritional supplement". [1] Trendione is listed in the United States Designer Anabolic Steroid Control Act of 2014. [1]

See also

References

  1. 1 2 3 Liane BJ, Magee C (October 2016). "Guerilla Warfare on the Pancreas? A Case of Acute Pancreatitis From a Supplement Known to Contain Anabolic-Androgenic Steroids". Mil Med. 181 (10): e1395 –e1397. doi: 10.7205/MILMED-D-15-00575 . PMID   27753588.
  2. ↑ Yarrow JF, McCoy SC, Borst SE (June 2010). "Tissue selectivity and potential clinical applications of trenbolone (17beta-hydroxyestra-4,9,11-trien-3-one): A potent anabolic steroid with reduced androgenic and estrogenic activity". Steroids. 75 (6): 377–89. doi:10.1016/j.steroids.2010.01.019. PMID   20138077. S2CID   205253265.
  3. ↑ Metzler M (April 1989). "Metabolism of some anabolic agents: toxicological and analytical aspects". J. Chromatogr. 489 (1): 11–21. doi:10.1016/s0378-4347(00)82880-7. PMID   2745641.
  4. ↑ Yarrow JF, Conover CF, McCoy SC, Lipinska JA, Santillana CA, Hance JM, Cannady DF, VanPelt TD, Sanchez J, Conrad BP, Pingel JE, Wronski TJ, Borst SE (April 2011). "17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone) exhibits tissue selective anabolic activity: effects on muscle, bone, adiposity, hemoglobin, and prostate". Am. J. Physiol. Endocrinol. Metab. 300 (4): E650–60. doi:10.1152/ajpendo.00440.2010. PMC   6189634 . PMID   21266670.
  5. ↑ Spranger B, Metzler M (April 1991). "Disposition of 17 beta-trenbolone in humans". J. Chromatogr. 564 (2): 485–92. doi:10.1016/0378-4347(91)80517-g. PMID   1874853.
  6. ↑ Advances in Agronomy. Elsevier. 13 April 2007. pp. 16–. ISBN   978-0-08-048819-6.
  7. ↑ Bauer ER, Daxenberger A, Petri T, Sauerwein H, Meyer HH (December 2000). "Characterisation of the affinity of different anabolics and synthetic hormones to the human androgen receptor, human sex hormone binding globulin and to the bovine progestin receptor". APMIS. 108 (12): 838–46. doi:10.1111/j.1600-0463.2000.tb00007.x. PMID   11252818. S2CID   22776408.
  8. ↑ Delettré J, Mornon JP, Lepicard G, Ojasoo T, Raynaud JP (January 1980). "Steroid flexibility and receptor specificity". J. Steroid Biochem. 13 (1): 45–59. doi:10.1016/0022-4731(80)90112-0. PMID   7382482.



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