RU-57073

RU-57073

Clinical data
Drug class	Nonsteroidal antiandrogen
Identifiers
IUPAC name 4-[3-(2-Hydroxyethyl)-4,4-dimethyl-5-oxo-2-sulfanylideneimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
CAS Number	143782-37-0  Y
PubChem CID	21884237
UNII	T5WKD9ULR6
CompTox Dashboard (EPA)	DTXSID201114393
Chemical and physical data
Formula	C15H14F3N3O2S
Molar mass	357.35 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1(C(=O)N(C(=S)N1CCO)C2=CC(=C(C=C2)C#N)C(F)(F)F)C
InChI InChI=1S/C15H14F3N3O2S/c1-14(2)12(23)21(13(24)20(14)5-6-22)10-4-3-9(8-19)11(7-10)15(16,17)18/h3-4,7,22H,5-6H2,1-2H3 Key:HNTMVNIRYPJDDJ-UHFFFAOYSA-N

RU-57073 is a nonsteroidal antiandrogen which was never marketed. ^{[1] [2] [3]} It shows 163% of the affinity of testosterone for the androgen receptor and negligible affinity for other steroid hormone receptors. ^{[1] [2]}

See also

• Cyanonilutamide
• Nilutamide
• RU-56187
• RU-58642
• RU-58841
• RU-59063

References

1. Singh SM, Gauthier S, Labrie F (February 2000). "Androgen receptor antagonists (antiandrogens): structure-activity relationships". Curr. Med. Chem. 7 (2): 211–47. doi:10.2174/0929867003375371. PMID   10637363.
2. Teutsch G, Goubet F, Battmann T, Bonfils A, Bouchoux F, Cerede E, Gofflo D, Gaillard-Kelly M, Philibert D (January 1994). "Non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the androgen receptor". J. Steroid Biochem. Mol. Biol. 48 (1): 111–9. doi:10.1016/0960-0760(94)90257-7. PMID   8136296. S2CID   31404295.
3. Münster U, Nakamura C, Haberland A, Jores K, Mehnert W, Rummel S, Schaller M, Korting HC, Zouboulis CC, Blume-Peytavi U, Schäfer-Korting M (January 2005). "RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia". Pharmazie. 60 (1): 8–12. PMID   15700772.