Asoprisnil

Asoprisnil

Clinical data
ATC code	None
Identifiers
IUPAC name (8S,11R,13S,14S,17S)-11-[4-[(E)-hydroxyiminomethyl]phenyl]-17-methoxy-17-(methoxymethyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
CAS Number	199396-76-4  N
PubChem CID	9577221
IUPHAR/BPS	2883
ChemSpider	7851660  Y
UNII	72W09924WP
KEGG	D02996  Y
ChEMBL	ChEMBL267431  Y
CompTox Dashboard (EPA)	DTXSID40904033
Chemical and physical data
Formula	C28H35NO4
Molar mass	449.591 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C5\C=C4/C(=C3/[C@@H](c1ccc(\C=N\O)cc1)C[C@]2([C@@H](CC[C@@]2(OC)COC)[C@@H]3CC4)C)CC5
InChI InChI=1S/C28H35NO4/c1-27-15-24(19-6-4-18(5-7-19)16-29-31)26-22-11-9-21(30)14-20(22)8-10-23(26)25(27)12-13-28(27,33-3)17-32-2/h4-7,14,16,23-25,31H,8-13,15,17H2,1-3H3/b29-16+/t23-,24+,25-,27-,28+/m0/s1 Y Key:GJMNAFGEUJBOCE-MEQIQULJSA-N Y
NY  (what is this?)    (verify)

Asoprisnil (INN; developmental code name J-867) is a synthetic, steroidal selective progesterone receptor modulator that was under development by Schering and TAP Pharmaceutical Products for the treatment of uterine fibroids. ^[1] In 2005, phase III clinical trials were discontinued due to endometrial changes in patients. ^[2]

See also

• Asoprisnil ecamate
• Mifepristone
• Ulipristal acetate
• Vilaprisan

References

1. DeManno D, Elger W, Garg R, et al. (2003). "Asoprisnil (J867): a selective progesterone receptor modulator for gynecological therapy". Steroids. 68 (10–13): 1019–32. doi:10.1016/j.steroids.2003.09.008. PMID   14667995. S2CID   23074350.
2. Schering Interim Report Q1-3 2005