Descinolone acetonide

Last updated
Descinolone acetonide
Descinolone acetonide.svg
Clinical data
SynonymsCL-27071; Desoxytriamcinolone acetonide; 21-Desoxytriamcinoline acetonide; 9α-Fluoro-11β,16α,17α-trihydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone; 9α-Fluoro-11β-hydroxy-16α,17α-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione
Drug class Corticosteroid; Glucocorticoid
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.016.699 Blue pencil.svg
Chemical and physical data
Formula C24H31FO5
Molar mass 418.505 g·mol−1
3D model (JSmol)

Descinolone acetonide (developmental code name CL-27071), also known as desoxytriamcinolone acetonide, is a synthetic glucocorticoid corticosteroid which was never marketed. [1]

Glucocorticoid class of corticosteroids

Glucocorticoids are a class of corticosteroids, which are a class of steroid hormones. Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor that is present in almost every vertebrate animal cell. The name "glucocorticoid" is a portmanteau and is composed from its role in regulation of glucose metabolism, synthesis in the adrenal cortex, and its steroidal structure. A less common synonym is glucocorticosteroid.

Corticosteroid steroid hormone

Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involved in a wide range of physiological processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior.

Related Research Articles

Triamcinolone chemical compound

Triamcinolone is a glucocorticoid used to treat certain skin diseases, allergies, and rheumatic disorders among others. It is also used to prevent worsening of asthma and COPD. It can be taken in various ways including by mouth, injection into a muscle, and inhaled.

Triamcinolone acetonide chemical compound

Triamcinolone acetonide is a synthetic corticosteroid used topically to treat various skin conditions, to relieve the discomfort of mouth sores, and intra-articularly by proceduralists to treat various joint conditions. In nasal spray form, it is used to treat allergic rhinitis. It is a more potent derivative of triamcinolone, and is about eight times as potent as prednisone.

Triamcinolone hexacetonide chemical compound

Triamcinolone hexacetonide is a synthetic glucocorticoid corticosteroid.

Fluocinolone acetonide chemical compound

Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. It was first synthesized in 1959 in the Research Department of Syntex Laboratories S.A. Mexico City. Preparations containing it were first marketed under the name Synalar. A typical dosage strength used in dermatology is 0.01–0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin.

Fluocinolone chemical compound

Fluocinolone is a synthetic glucocorticoid corticosteroid which was never marketed. The acetonide cyclic ketal of fluocinolone, fluocinolone acetonide, in contrast, has been marketed.

Triamcinolone furetonide chemical compound

Triamcinolone furetonide is a synthetic glucocorticoid corticosteroid which was never marketed.

Triamcinolone benetonide chemical compound

Triamcinolone benetonide is a synthetic glucocorticoid corticosteroid.

Algestone chemical compound

Algestone (INN), also known as alphasone or alfasone, as well as dihydroxyprogesterone, is a progestin which was never marketed. Another progestin, algestone acetophenide, in contrast, has been marketed as a hormonal contraceptive.

Fluclorolone chemical compound

Fluclorolone is a synthetic glucocorticoid corticosteroid which was never marketed. The acetonide cyclic ketal of fluclorolone, fluclorolone acetonide, in contrast, has been marketed.

Algestone acetonide chemical compound

Algestone acetonide, also known as algestone 16α,17α-acetonide or 16α,17α-isopropylidenedioxyprogesterone, is a progestin which was never marketed. It is the acetonide cyclic ketal of algestone. Another progestin, algestone acetophenide, in contrast, has been marketed.

Ciprocinonide chemical compound

Ciprocinonide, also known as fluocinolone acetonide cyclopropylcarboxylate, is a synthetic glucocorticoid corticosteroid which was never marketed.

Procinonide chemical compound

Procinonide is a synthetic glucocorticoid corticosteroid which was never marketed.

Flupamesone chemical compound

Flupamesone, also known as triamcinolone acetonide metembonate, is a synthetic glucocorticoid corticosteroid which is marketed in Spain. It is a dimer of a C21 ester of triamcinolone acetonide.

In organic chemistry, acetophenide is a functional group which is composed of the cyclic ketal of a diol with acetophenone. It is seen in algestone acetophenide and amcinafide.

In organic chemistry, acroleinide is a functional group which is composed of a cyclic ketal of a diol with acrolein. It is seen in acrocinonide.

In organic chemistry, pentanonide is a functional group which is composed of a cyclic ketal of a diol with 3-pentanone. It is seen in amcinafal.

In organic chemistry, cyclopentanonide is a functional group which is composed of a cyclic ketal of a diol with cyclopentanone. It is seen in amcinonide.

In organic chemistry, aminobenzal is a functional group which is composed of a cyclic ketal of a diol with 4-dimethylaminobenzylidene. It is seen in triamcinolone aminobenzal benzamidoisobutyrate.

References

  1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 362–. ISBN   978-1-4757-2085-3.