Fluocortolone

Fluocortolone
Clinical data
Other names	(6S,8S,9R,10S,11S,13S,14S,16R,17S)-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
Routes of; administration	Ointment, suppositories
ATC code	C05AA08 ( WHO ) D07AC05 ( WHO ) H02AB03 ( WHO );
Identifiers
	IUPAC name (1S,2R,8S,10S,11S,13R,14S,15S,17S)-8-fluoro-17-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one;
CAS Number	152-97-6 ;
PubChem CID	9053 ;
DrugBank	DB08971 ;
ChemSpider	8701 ;
UNII	65VXC1MH0J ;
KEGG	D04218 ;
ChEMBL	ChEMBL251634 ;
CompTox Dashboard (EPA)	DTXSID00861835 ;
ECHA InfoCard	100.005.284
Chemical and physical data
Formula	C22H29FO4
Molar mass	376.468 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES O=C\1\C=C/[C@]4(/C(=C/1)[C@@H](F)C[C@@H]2[C@@H]4[C@@H](O)C[C@@]3([C@@H](C(=O)CO)[C@@H](C[C@@H]23)C)C)C;
	InChI InChI=1S/C22H29FO4/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-21(15,2)20(13)17(26)9-22(14,3)19(11)18(27)10-24/h4-5,7,11,13-14,16-17,19-20,24,26H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20-,21+,22+/m1/s1 ; Key:GAKMQHDJQHZUTJ-ULHLPKEOSA-N ;
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Last updated December 31, 2025

Fluocortolone is a glucocorticoid ^[1] used in the treatment of several conditions, including hemorrhoids.

It is similar to fluocortin, but with one less carbonyl group.

References

↑ Munro DD, Wilson HT, Rhodes EL (November 1967). "Comparison of betamethasone 17-valerate ointment with fluocortolone and fluocortolone caproate ointment". British Medical Journal. 4 (5574): 275–6. doi:10.1136/bmj.4.5574.275. PMC 1748932 . PMID 6054003.

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[pmid6054003-1] Munro DD, Wilson HT, Rhodes EL (November 1967). "Comparison of betamethasone 17-valerate ointment with fluocortolone and fluocortolone caproate ointment". British Medical Journal. 4 (5574): 275–6. doi:10.1136/bmj.4.5574.275. PMC 1748932 . PMID 6054003.

[1]

Clinical data

Other names	(6S,8S,9R,10S,11S,13S,14S,16R,17S)-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
Routes of administration	Ointment, suppositories
ATC code	C05AA08 ( WHO ) D07AC05 ( WHO ) H02AB03 ( WHO )
Identifiers
IUPAC name (1S,2R,8S,10S,11S,13R,14S,15S,17S)-8-fluoro-17-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^2,7.0^11,15]heptadeca-3,6-dien-5-one
CAS Number	152-97-6 ^N
PubChem CID	9053
DrugBank	DB08971 ^N
ChemSpider	8701 ^Y
UNII	65VXC1MH0J
KEGG	D04218 ^Y
ChEMBL	ChEMBL251634 ^Y
CompTox Dashboard (EPA)	DTXSID00861835
ECHA InfoCard	100.005.284
Chemical and physical data
Formula	C₂₂H₂₉FO₄
Molar mass	376.468 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C\1\C=C/[C@]4(/C(=C/1)[C@@H](F)C[C@@H]2[C@@H]4[C@@H](O)C[C@@]3([C@@H](C(=O)CO)[C@@H](C[C@@H]23)C)C)C
InChI InChI=1S/C22H29FO4/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-21(15,2)20(13)17(26)9-22(14,3)19(11)18(27)10-24/h4-5,7,11,13-14,16-17,19-20,24,26H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20-,21+,22+/m1/s1^Y Key:GAKMQHDJQHZUTJ-ULHLPKEOSA-N^Y
^NY (what is this?) (verify)

Fluocortolone

See also

References