Mazipredone

Last updated
Mazipredone
Mazipredone.svg
Clinical data
Trade names Depersolon
Synonyms Depersolone; Methylpiperazinyl deoxyprednisolone; Deoxymethylpiperazinyl prednisolone; 11β,17α-Dihydroxy-21-(4-methyl-1-piperazinyl)pregna-1,4-diene-3,20-dione
Drug class Corticosteroid; Glucocorticoid
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
Formula C26H38N2O4
Molar mass 442.60 g·mol−1
3D model (JSmol)

Mazipredone (brand name Depersolon), also known as depersolone, is a synthetic glucocorticoid corticosteroid which is or has been marketed in the Czech Republic and Hungary. [1] [2]

Glucocorticoid class of corticosteroids

Glucocorticoids are a class of corticosteroids, which are a class of steroid hormones. Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor that is present in almost every vertebrate animal cell. The name "glucocorticoid" is a portmanteau and is composed from its role in regulation of glucose metabolism, synthesis in the adrenal cortex, and its steroidal structure. A less common synonym is glucocorticosteroid.

Corticosteroid steroid hormone

Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involved in a wide range of physiological processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior.

Czech Republic Republic in Central Europe

The Czech Republic, also known by its short-form name, Czechia, is a landlocked country in Central Europe bordered by Germany to the west, Austria to the south, Slovakia to the east and Poland to the northeast. The Czech Republic covers an area of 78,866 square kilometres (30,450 sq mi) with a mostly temperate continental climate and oceanic climate. It is a unitary parliamentary republic, with 10.6 million inhabitants; its capital and largest city is Prague, with 1.3 million residents. Other major cities are Brno, Ostrava, Olomouc and Pilsen. The Czech Republic is a member of the European Union (EU), NATO, the OECD, the United Nations, the OSCE, and the Council of Europe.

Related Research Articles

Fluticasone chemical compound

Fluticasone are two manufactured steroids used to treat nasal symptoms. Both the furoate and propanoate esters, fluticasone furoate and fluticasone propionate, are also used as topical anti-inflammatories and inhaled corticosteroids, and are used much more commonly in comparison.

Clobetasol chemical compound

Clobetasol is a synthetic glucocorticoid corticosteroid which is marketed in Denmark. A propionate ester of clobetasol, clobetasol propionate, has also been marketed, and is far more widely used in comparison.

Fluocinolone chemical compound

Fluocinolone is a synthetic glucocorticoid corticosteroid which was never marketed. The acetonide cyclic ketal of fluocinolone, fluocinolone acetonide, in contrast, has been marketed.

Fluprednidene chemical compound

Fluprednidene, also known as fluprednylidene, is a synthetic glucocorticoid corticosteroid which was never marketed. An acetate ester of fluprednidene, fluprednidene acetate, in contrast, has been marketed.

Prednimustine chemical compound

Prednimustine, sold under the brand names Mostarina and Sterecyst, is a medication which is used in chemotherapy in the treatment of leukemias and lymphomas. It is the ester formed from two other drugs, prednisolone and chlorambucil. Rarely, it has been associated with myoclonus.

Prothipendyl chemical compound

Prothipendyl, also known as azaphenothiazine or phrenotropin, is an anxiolytic, antiemetic, and antihistamine of the azaphenothiazine group which is marketed in Europe and is used to treat anxiety and agitation in psychotic syndromes. It differs from promazine only by the replacement of one carbon atom with a nitrogen atom in the tricyclic ring system. Prothipendyl is said to not possess antipsychotic effects, and in accordance, appears to be a weaker dopamine receptor antagonist than other phenothiazines.

Oxymesterone chemical compound

Oxymesterone, also known as methandrostenediolone, as well as 4-hydroxy-17α-methyltestosterone or 17α-methylandrost-4-en-4,17β-diol-3-one, is an orally active anabolic-androgenic steroid (AAS). It was known by 1960.

Hydrocortamate chemical compound

Hydrocortamate is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. It is used topically to treat inflammation due to corticosteroid-responsive dermatoses.

Fluclorolone chemical compound

Fluclorolone is a synthetic glucocorticoid corticosteroid which was never marketed. The acetonide cyclic ketal of fluclorolone, fluclorolone acetonide, in contrast, has been marketed.

Quinestradol chemical compound

Quinestradol, also known as quinestradiol or quinestriol, as well as estriol 3-cyclopentyl ether (E3CPE), is a synthetic estrogen and estrogen ether which is no longer marketed. It is the 3-cyclopentyl ether of estriol. The medication has been studied in the treatment of stress incontinence in elderly women, with effectiveness observed.

Broparestrol chemical compound

Broparestrol (INN), also known as α-bromo-α,β-diphenyl-β-p-ethylphenylethylene (BDPE), is a synthetic, nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that has been used in Europe as a dermatological agent and for the treatment of breast cancer. The drug is described as slightly estrogenic and potently antiestrogenic, and inhibits mammary gland development and suppresses prolactin levels in animals. It is structurally related to clomifene and diethylstilbestrol. Broparestrol is a mixture of E- and Z- isomers, both of which are active and are similarly antiestrogenic but, unlike broparestrol, were never marketed.

Diflorasone chemical compound

Diflorasone is a synthetic glucocorticoid corticosteroid which was never marketed. A diacetate ester of diflorasone, diflorasone diacetate, in contrast, has been marketed.

Estramustine chemical compound

Estramustine is a estrogen and cytostatic antineoplastic agent which was never marketed. It is an estrogen ester – specifically, the C3 normustine ester of estradiol – and acts in part as a prodrug of estradiol in the body. Estramustine phosphate, the C17β phosphate ester of estramustine and a prodrug of estramustine, estromustine, estradiol, and estrone, is marketed and used in the treatment of prostate cancer.

Dichlorisone chemical compound

Dichlorisone is a synthetic glucocorticoid corticosteroid which was never marketed.

Isoflupredone chemical compound

Isoflupredone, also known as deltafludrocortisone and 9α-fluoroprednisolone, is a synthetic glucocorticoid corticosteroid which was never marketed.

Prednazoline, a compound of prednisolone phosphate with fenoxazoline, is a synthetic corticosteroid as well as vasoconstrictor and α-adrenergic sympathomimetic.

Prednisolamate chemical compound

Prednisolamate, also known as prednisolone 21-diethylaminoacetate, is a synthetic corticosteroid. It is or was a component of Etaproctene, which contains lidocaine, prednisolamate hydrochloride, and tetryzoline.

Fluocortin butyl chemical compound

Fluocortin butyl, or fluocortin 21-butylate, is a synthetic glucocorticoid corticosteroid which is marketed in Germany, Belgium, Luxembourg, Spain, and Italy. Chemically, it is the butyl ester derivative of fluocortin.

Fluazacort chemical compound

Fluazacort is a synthetic glucocorticoid corticosteroid which is marketed in Italy.

Cortobenzolone chemical compound

Cortobenzolone, also known as betamethasone salicylate, is a synthetic glucocorticoid corticosteroid and corticosteroid ester which is marketed in Spain.

References

  1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 750,755. ISBN   978-1-4757-2085-3.
  2. Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 632–. ISBN   978-3-88763-075-1.