Fluclorolone acetonide

Last updated
Fluclorolone acetonide
Fluclorolone acetonide skeletal.svg
Fluclorolone acetonide.png
Clinical data
Trade names Cutanit, Topicon
Routes of
administration
Topical
ATC code
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.020.919 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C24H29Cl2FO5
Molar mass 487.39 g·mol−1
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Fluclorolone acetonide (INN, or flucloronide, USAN, trade names Cutanit, Topicon) is a corticosteroid for topical use on the skin. [1]

Free fluclorolone, without the acetonide (C21H25Cl2FO5, CID 60900 from PubChem
) Fluclorolone skeletal.svg
Free fluclorolone, without the acetonide (C21H25Cl2FO5, CID 60900 from PubChem )

Related Research Articles

ATC code D07Corticosteroids, dermatological preparations is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. Subgroup D07 is part of the anatomical group D Dermatologicals.

<span class="mw-page-title-main">Triamcinolone</span> Steroid medication

Triamcinolone is a glucocorticoid used to treat certain skin diseases, allergies, and rheumatic disorders among others. It is also used to prevent worsening of asthma and COPD. It can be taken in various ways including by mouth, injection into a muscle, and inhalation.

<span class="mw-page-title-main">Triamcinolone acetonide</span> Medicinal chemical compound, steroid

Triamcinolone acetonide, sold under the brand name Kenalog among others, is a synthetic corticosteroid medication used topically to treat various skin conditions, to relieve the discomfort of mouth sores, and by injection into joints to treat various joint conditions. It is also injected into lesions to treat inflammation in some parts of the body, particularly the skin. In nasal spray form, it is used to treat allergic rhinitis. It is used for the treatment of macular edema associated with uveitis. It is a more potent derivative of triamcinolone, and is about eight times as potent as prednisone.

<span class="mw-page-title-main">2,2-Dimethoxypropane</span> Chemical compound

2,2-Dimethoxypropane (DMP) is an organic compound with the formula (CH3)2C(OCH3)2. A colorless liquid, it is the product of the condensation of acetone and methanol. DMP is used as a water scavenger in water-sensitive reactions. Upon acid-catalyzed reaction, DMP reacts quantitatively with water to form acetone and methanol. This property can be used to accurately determine the amount of water in a sample, alternatively to the Karl Fischer method.

<span class="mw-page-title-main">Fluocinolone acetonide</span> Corticosteroid anti-inflammatory drug

Fluocinolone acetonide is a fluorinated corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. It was first synthesized in 1959 in the Research Department of Syntex Laboratories S.A. Mexico City. Preparations containing it were first marketed under the brand name Synalar.

<span class="mw-page-title-main">Fluocinolone</span> Synthetic glucocorticoid corticosteroid

Fluocinolone is a synthetic glucocorticoid corticosteroid which was never marketed. The acetonide cyclic ketal of fluocinolone, fluocinolone acetonide, in contrast, has been marketed.

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Topical steroids are the topical forms of corticosteroids. Topical steroids are the most commonly prescribed topical medications for the treatment of rash and eczema. Topical steroids have anti-inflammatory properties and are classified based on their skin vasoconstrictive abilities. There are numerous topical steroid products. All the preparations in each class have the same anti-inflammatory properties but essentially differ in base and price.

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<span class="mw-page-title-main">Fluclorolone</span> Chemical compound

Fluclorolone is a synthetic glucocorticoid corticosteroid which was never marketed. The acetonide cyclic ketal of fluclorolone, fluclorolone acetonide, in contrast, has been marketed.

<span class="mw-page-title-main">Acetonide</span> Chemical compound

In organic chemistry, an acetonide is the functional group composed of the cyclic ketal of a diol with acetone. The more systematic name for this structure is an isopropylidene ketal. Acetonide is a common protecting group for 1,2- and 1,3-diols. The protecting group can be removed by hydrolysis of the ketal using dilute aqueous acid.

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<span class="mw-page-title-main">Algestone acetonide</span> Chemical compound

Algestone acetonide, also known as algestone 16α,17α-acetonide or 16α,17α-isopropylidenedioxyprogesterone, is a progestin which was never marketed. It is the acetonide cyclic ketal of algestone. Another progestin, algestone acetophenide, in contrast, has been marketed.

<span class="mw-page-title-main">Ciprocinonide</span> Chemical compound

Ciprocinonide, also known as fluocinolone acetonide cyclopropylcarboxylate, is a synthetic glucocorticoid corticosteroid which was never marketed.

<span class="mw-page-title-main">Descinolone acetonide</span> Chemical compound

Descinolone acetonide, also known as desoxytriamcinolone acetonide, is a synthetic glucocorticoid corticosteroid which was never marketed.

<span class="mw-page-title-main">Procinonide</span> Chemical compound

Procinonide is a synthetic glucocorticoid corticosteroid which was never marketed.

<span class="mw-page-title-main">Flupamesone</span> Chemical compound

Flupamesone, also known as triamcinolone acetonide metembonate, is a synthetic glucocorticoid corticosteroid which is marketed in Spain. It is a dimer of a C21 ester of triamcinolone acetonide.

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References

  1. Cunliffe WJ (March 1976). "Long-term treatment with 0-01% fluclorolone acetonide in children". British Medical Journal. 1 (6010): 627. doi:10.1136/bmj.1.6010.627. PMC   1639042 . PMID   1252855.