Combination of | |
---|---|
Prednisolone | Glucocorticoid |
Perphenazine | Major tranquilizer |
Clinical data | |
Trade names | Sixty Six-20 (with chlorpheniramine) |
Other names | Prednisolone hemisuccinate compound with perphenazine; SCH-6620; 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione, 21-(hydrogen succinate), compound with 4-(3-(2-chlorophenothiazin-10-yl)propyl)-1-piperazineethanol (1:1) |
Drug class | Corticosteroid; Glucocorticoid |
Identifiers | |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
CompTox Dashboard (EPA) |
Prednazate, a combination of prednisolone hemisuccinate with perphenazine, is a synthetic glucocorticoid corticosteroid as well as typical antipsychotic and sedative/tranquilizer. [1] It was a component of Sixty Six-20, [1] a combination of prednazate (prednisolone hemisuccinate and perphenazine) and chlorpheniramine. [2]
Perphenazine is a typical antipsychotic drug. Chemically, it is classified as a piperazinyl phenothiazine. Originally marketed in the United States as Trilafon, it has been in clinical use for decades.
Prednisone is a glucocorticoid medication mostly used to suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic diseases. It is also used to treat high blood calcium due to cancer and adrenal insufficiency along with other steroids. It is taken by mouth.
Hydrocortisone is the name for the hormone cortisol when supplied as a medication. Uses include conditions such as adrenocortical insufficiency, adrenogenital syndrome, high blood calcium, thyroiditis, rheumatoid arthritis, dermatitis, asthma, and COPD. It is the treatment of choice for adrenocortical insufficiency. It can be given by mouth, topically, or by injection. Stopping treatment after long-term use should be done slowly.
Prednisolone is a steroid medication used to treat certain types of allergies, inflammatory conditions, autoimmune disorders, and cancers. Some of these conditions include adrenocortical insufficiency, high blood calcium, rheumatoid arthritis, dermatitis, eye inflammation, asthma, and multiple sclerosis. It can be taken by mouth, injected into a vein, used topically as a skin cream, or as eye drops.
ATC code D07Corticosteroids, dermatological preparations is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. Subgroup D07 is part of the anatomical group D Dermatologicals.
ATC code H02Corticosteroids for systemic use is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. Subgroup H02 is part of the anatomical group H Systemic hormonal preparations, excluding sex hormones and insulins.
Methylprednisolone succinate, sold under the brand names Solu-Medrol among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically the C21 succinate ester of methylprednisolone—which is used by intravenous administration. Methylprednisolone succinate is provided as two different salts when used as a pharmaceutical drug: a sodium salt and a hydrogen salt.
Haloperidol decanoate, sold under the brand name Haldol Decanoate among others, is a typical antipsychotic which is used in the treatment of schizophrenia. It is administered by injection into muscle at a dose of 100 to 200 mg once every 4 weeks or monthly. The dorsogluteal site is recommended. A 3.75-cm (1.5-inch), 21-gauge needle is generally used, but obese individuals may require a 6.5-cm (2.5-inch) needle to ensure that the drug is indeed injected intramuscularly and not subcutaneously. Haloperidol decanoate is provided in the form of 50 or 100 mg/mL oil solution of sesame oil and benzyl alcohol in ampoules or pre-filled syringes. Its elimination half-life after multiple doses is 21 days. The medication is marketed in many countries throughout the world.
Bromperidol, sold under the brand names Bromidol and Impromen among others, is a typical antipsychotic of the butyrophenone group which is used in the treatment of schizophrenia. It was discovered at Janssen Pharmaceutica in 1966. An ester prodrug, bromperidol decanoate, is a long-acting form of bromperidol used as a depot injectable.
Prednimustine, sold under the brand names Mostarina and Sterecyst, is a medication which is used in chemotherapy in the treatment of leukemias and lymphomas. It is the ester formed from two other drugs, prednisolone and chlorambucil. Rarely, it has been associated with myoclonus.
BL-1020 (perphenazine 4-aminobutanoate) is an investigational orally-active antipsychotic for the possible treatment of schizophrenia. The chemical is an ester of GABA and perphenazine; pharmacologically it acts as a D2 antagonist and GABA agonist. It has shown pro-cognitive effects in the trials. In March 2013, it went into the II/III trial phase. It has been introduced by BioLineRx, a biopharmaceutical development company.
Tranylcypromine/trifluoperazine is a combination formulation of the monoamine oxidase inhibitor antidepressant drug tranylcypromine and the typical antipsychotic drug trifluoperazine that has been used in the treatment of major depressive disorder. It contains 10 mg tranylcypromine and 1 mg trifluoperazine. The drug has been in clinical use since at least 1961.
Nandrolone hydrogen succinate, or nandrolone hemisuccinate, also known as 19-nortestosterone 17β-(3-carboxy)propionate, is a synthetic androgen and anabolic steroid and a nandrolone ester that is or has been marketed in Italy.
Pregnenolone succinate is a synthetic pregnane steroid and an ester of pregnenolone which is described as a glucocorticoid and anti-inflammatory drug and has been patented and marketed as a topical medication in the form of a cream for the treatment of allergic, pruritic, and inflammatory dermatitis. It has also been described as a non-hormonal sterol, having neurosteroid activity, and forming a progesterone analogue via dehydrogenation.
Prednazoline, a compound of prednisolone phosphate with fenoxazoline, is a synthetic corticosteroid as well as vasoconstrictor and α-adrenergic sympathomimetic.
Prednisolamate, also known as prednisolone 21-diethylaminoacetate, is a synthetic corticosteroid. It is or was a component of Etaproctene, which contains lidocaine, prednisolamate hydrochloride, and tetryzoline.
Hydrocortisone hemisuccinate (USAN), also known as hydrocortisone hydrogen succinate (BANM) or simply hydrocortisone succinate and sold under the brand name Solu-Cortel among many others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester which is used for antiinflammatory and antiallergic indications.
Estradiol hemisuccinate/progesterone (EHS/P4), sold under the brand name Hosterona, is an injectable combination medication of estradiol hemisuccinate (EHS), an estrogen, and progesterone (P4), a progestogen, which is used to induce withdrawal bleeding in women with non-pregnancy-related amenorrhea. It is provided in the form of ampoules containing 20 mg/2 mL EHS and 100 mg/2 mL P4 and is administered by intramuscular injection. The medication is available in Argentina and Paraguay.
Bromperidol decanoate, sold under the brand names Bromidol Depot, Bromodol Decanoato, and Impromen Decanoas, is an antipsychotic which has been marketed in Europe and Latin America. It is an antipsychotic ester and long-acting prodrug of bromperidol which is administered by depot intramuscular injection once every 4 weeks.