Dichlorisone

Dichlorisone
Clinical data
Synonyms	9,11β-Dichloro-17α,21-dihydroxypregna-1,4-diene-3,20-dione
Drug class	Corticosteroid; Glucocorticoid
Identifiers
	IUPAC name (8S,9R,10S,11S,13S,14S,17R)-9,11-Dichloro-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one;
CAS Number	7008-26-6 ;
PubChem CID	20054892 ;
ChemSpider	16735776 ;
UNII	AMW2MRV3OT ;
KEGG	D07814 ;
Chemical and physical data
Formula	C21H26Cl2O4
Molar mass	413.34 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@@]43C)Cl)Cl;
	InChI InChI=1S/C21H26Cl2O4/c1-18-7-5-13(25)9-12(18)3-4-15-14-6-8-20(27,17(26)11-24)19(14,2)10-16(22)21(15,18)23/h5,7,9,14-16,24,27H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1; Key:CZJXBZPJABCCRQ-BULBTXNYSA-N;

Last updated March 24, 2019

Dichlorisone is a synthetic glucocorticoid corticosteroid which was never marketed.^[1]^[2]

Glucocorticoids are a class of corticosteroids, which are a class of steroid hormones. Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor that is present in almost every vertebrate animal cell. The name "glucocorticoid" is a portmanteau and is composed from its role in regulation of glucose metabolism, synthesis in the adrenal cortex, and its steroidal structure. A less common synonym is glucocorticosteroid.

Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involved in a wide range of physiological processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior.

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References

↑ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 381. ISBN 978-1-4757-2085-3.
↑ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 325–. ISBN 978-3-88763-075-1.

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[Elks2014-1] J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 381. ISBN 978-1-4757-2085-3.

[IndexNominum2000-2] Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 325–. ISBN 978-3-88763-075-1.