Endrisone

Endrisone
Clinical data
Trade names	Aldrisone
Synonyms	Delta-medrysone; [1] 6α-Methyl-11β-hydroxypregna-1,4-diene-3,20-dione; 6α-Methyl-11β-hydroxy-Δ1-progesterone
Routes of; administration	Topical, ophthalmic [1] [2]
Identifiers
	IUPAC name (6S,8S,9S,10R,11S,13S,14S,17S)-17-acetyl-11-hydroxy-6,10,13-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one;
CAS Number	35100-44-8 ;
PubChem CID	71422 ;
ChemSpider	64512 ;
UNII	1QZ096EIEF ;
KEGG	D03995 ;
ChEMBL	ChEMBL2104631 ;
ECHA InfoCard	100.047.587
Chemical and physical data
Formula	C22H30O3
Molar mass	342.479 g/mol g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@@H]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)C(=O)C;
	InChI InChI=1S/C22H30O3/c1-12-9-15-17-6-5-16(13(2)23)22(17,4)11-19(25)20(15)21(3)8-7-14(24)10-18(12)21/h7-8,10,12,15-17,19-20,25H,5-6,9,11H2,1-4H3/t12-,15-,16+,17-,19-,20+,21-,22+/m0/s1; Key:VDNZZIYSCXESNI-ILSZZQPISA-N;

Last updated June 05, 2019

Endrisone (INN) (brand name Aldrisone), or endrysone (USAN), is a synthetic, steroidal glucocorticoid which is or has been marketed in Italy by SIFI.^[1]^[2]^[3] It is used as a topical and ophthalmic anti-inflammatory drug in the treatment of skin and eye conditions, respectively.^[1]^[2]

United States Adopted Names are unique nonproprietary names assigned to pharmaceuticals marketed in the United States. Each name is assigned by the USAN Council, which is co-sponsored by the American Medical Association (AMA), the United States Pharmacopeial Convention (USP), and the American Pharmacists Association (APhA).

A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes which alter membrane fluidity; and as signaling molecules. Hundreds of steroids are found in plants, animals and fungi. All steroids are manufactured in cells from the sterols lanosterol (opisthokonts) or cycloartenol (plants). Lanosterol and cycloartenol are derived from the cyclization of the triterpene squalene.

Glucocorticoids are a class of corticosteroids, which are a class of steroid hormones. Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor that is present in almost every vertebrate animal cell. The name "glucocorticoid" is a portmanteau and is composed from its role in regulation of glucose metabolism, synthesis in the adrenal cortex, and its steroidal structure. A less common synonym is glucocorticosteroid.

Related Research Articles

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Chlorproethazine, sold under the brand name Neuriplege, is a drug of the phenothiazine group described as a muscle relaxant or tranquilizer which is or has been marketed in Europe as a topical cream for the treatment of muscle pain. It has been associated with photoallergic contact dermatitis.

Prothipendyl, also known as azaphenothiazine or phrenotropin, is an anxiolytic, antiemetic, and antihistamine of the azaphenothiazine group which is marketed in Europe and is used to treat anxiety and agitation in psychotic syndromes. It differs from promazine only by the replacement of one carbon atom with a nitrogen atom in the tricyclic ring system. Prothipendyl is said to not possess antipsychotic effects, and in accordance, appears to be a weaker dopamine receptor antagonist than other phenothiazines.

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References

1 2 3 4 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 486–. ISBN 978-1-4757-2085-3.
1 2 3 I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 110–. ISBN 978-94-011-4439-1.
↑ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 386–. ISBN 978-3-88763-075-1.

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[Elks2014-1] 1 2 3 4 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 486–. ISBN 978-1-4757-2085-3.

[MortonHall2012-2] 1 2 3 I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 110–. ISBN 978-94-011-4439-1.

[IndexNominum2000-3] Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 386–. ISBN 978-3-88763-075-1.

Endrisone

See also

Related Research Articles

References