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Clinical data | |
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Other names | 6α-Chloro-1,4-pregnadiene-17a,21-diol-3,11,20-trione |
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ECHA InfoCard | 100.052.387 |
Chemical and physical data | |
Formula | C21H25ClO5 |
Molar mass | 392.88 g·mol−1 |
3D model (JSmol) | |
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Chloroprednisone is a topical glucocorticoid first reported in 1960. [1] It is a chlorinated derivative of prednisone. The acetate ester prodrug, chloroprednisone 21-acetate, was sold under the brand name Topilan as an anti-inflammatory agent. [2] [3]
There is little published about chloroprednisone. This may be due to limited activity topically because the skin lacks the necessary activating enzyme 11β-Hydroxysteroid dehydrogenase. Systemically, this agent's activity on glucocorticoid receptors may not have competed with agents like fludrocortisone or dexamethasone.