Flumetasone pivalate

Flumetasone pivalate

Clinical data
Other names	Flumetasone 21-pivalate
Drug class	Corticosteroid; Glucocorticoid
Identifiers
IUPAC name (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-17-(2-(2,2-dimethylpropionyl)oxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CAS Number	2002-29-1
PubChem CID	443980
UNII	0DV09X6F21
CompTox Dashboard (EPA)	DTXSID7049005
ECHA InfoCard	100.016.275
Chemical and physical data
Formula	C27H36F2O6
Molar mass	494.576 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)C(C)(C)C)O)C)O)F)C)F
InChI InChI=1S/C27H36F2O6/c1-14-9-16-17-11-19(28)18-10-15(30)7-8-24(18,5)26(17,29)20(31)12-25(16,6)27(14,34)21(32)13-35-22(33)23(2,3)4/h7-8,10,14,16-17,19-20,31,34H,9,11-13H2,1-6H3/t14-,16+,17+,19+,20+,24+,25+,26+,27+/m1/s1 Key:JWRMHDSINXPDHB-OJAGFMMFSA-N

Flumetasone pivalate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It is the 21-acetate ester of flumetasone. ^{[1] [2] [3]}

References

1. A Sayed R, Mohamed AR, Hassan WS, Elmasry MS (June 2021). "Comparative study of novel green UV-spectrophotometric platforms for simultaneous rapid analysis of flumethasone pivalate and clioquinol in their combined formulation". Drug Development and Industrial Pharmacy. 47 (6): 867–877. doi:10.1080/03639045.2021.1908341. PMID   34224277. S2CID   235746754.
2. "Flumethasone pivalate (Locorten). Anti-inflammatory, antipruritic". Clinical Pharmacology and Therapeutics. 11 (6): 927–929. 1970-11-06. doi:10.1002/cpt1970116927. PMID   5481576. S2CID   126851.
3. Hopkała H, Przyborowski L (June 1988). "Determination of drugs containing fluorine with ion-selective electrode. Part 1: Synthetic glucocorticosteroids". Die Pharmazie. 43 (6): 422–423. PMID   3212030.